Eosinophilic esophagitis and esophageal atresia: coincidence or causality?

Salgado, Karen V Stave; Rocca, Ana

doi:10.5546/aap.2018.eng.e61

Cited by 6 publications

(7 citation statements)

References 23 publications

(55 reference statements)

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“…EoE is an emerging entity, the prevalence of which is currently 1 to 5 per 10,000 [ 5 ], despite increasing due to improved awareness and therefore more frequent diagnoses. In the last ten years, some studies have postulated a strict correlation between EoE and EA [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this context, despite recent data suggesting that EA patients may have an increased incidence of EoE compared to the general population [ 9 ], the concomitant presence of EoE and EA may be difficult to suspect, as EoE partially overlaps with EA’s common gastrointestinal manifestations or GERD symptoms [ 8 ]. The aim of the present study is to report on the demographic and clinical characteristics of EoE in patients treated for EA compared to those of the EoE-only population.…”

Section: Introductionmentioning

confidence: 99%

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Eosinophilic Esophagitis in Esophageal Atresia: Is It Really a New Disease?

et al. 2022

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Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disease. Symptoms are related to mucosal eosinophilic-predominant inflammation that leads to esophageal dysfunction. Recent data suggest that esophageal atresia (EA) patients may have an increased incidence of EoE compared to the general population. As EoE symptoms may be confused with EA-related symptoms, they may significantly worsen morbidity in this specific group of patients. We investigated specific characteristics of patients with AE and EoE compared to those with EoE only. We conducted an observational retrospective monocentric study including all patients diagnosed with EoE from 1 January 2010 to 31 December 2021. For each patient, demographic, clinical and histopathological data were collected and then compared between the two cohorts (EA-EoE vs. EoE only). During the study period, 62 patients were included: 17 children were in the follow-up because of EA (18.1% of 94 EA patients screened in that period), while the other 45 presented EoE only. The demographic and clinical features of EA-EoE patients demonstrate a lower prevalence of allergic subjects (23.5% vs. 80%, p < 0.05), a lower age of presentation (3.1 vs. 12.2 years, p < 0.05), non-specific symptoms and a higher resolution rate with PPI therapy (64.7% vs. 17.8%, p < 0.05) compared to EoE-only patients. Our data confirm that EA patients are at high risk for developing EoE. As symptoms may overlap with the EA spectrum, early recognition of EoE may prevent patients from receiving unnecessary invasive therapeutic interventions and from developing complications from untreated EoE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eosinophilic Esophagitis in Esophageal Atresia: Is It Really a New Disease?

et al. 2022

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“…No controlled studies on the prevalence of EoE in EA patients have been carried out. Although by 2015, 48 cases of EoE in EA had been reported, by l the beginning of 2019, this had increased to 101 reported cases of EoE in EA patients in literature (3, 4). The largest reported cohort of EoE in EA patients was in a study by Dhaliwal et al from 2013, where a retrospective review of all biopsies from an esophageal atresia cohort of 103 showed an incidence of 17% (5).…”

Section: Prevalencementioning

confidence: 98%

“…Other case series of EoE in EA patients include Yasuda et al (15.2%), Gorter et al (1.25%), Pedersen et al (10%), Batres et al (3%), Oliveira et al (4%), Yamada et al (6%), Kassabian et al (5%), and Lardenois et al (9.5%) (3, 6–13). These figures are significantly higher than the reported incidence of 8–10% EoE in children with suspected GERD not responding to standard anti-reflux treatment (14, 15).…”

Section: Prevalencementioning

confidence: 98%

Eosinophilic Esophagitis in Esophageal Atresia

Krishnan

2019

Front. Pediatr.

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Recent studies have reported a higher prevalence of eosinophilic esophagitis in children with esophageal atresia. Under recognition of eosinophilic esophagitis in these patients may lead to excessive use of antireflux therapy and an escalation of interventions, including fundoplication, as symptoms may be attributed to gastroesophageal reflux disease. In addition, long-term untreated eosinophilic esophagitis may lead to recurrent strictures due to transmural esophageal inflammation, necessitating repeated dilatations. Eosinophilic esophagitis should be considered when children with esophageal atresia show persistent symptoms on standard antireflux treatment, increasing dysphagia, and recurrent strictures. Treatment has been found to not only significantly reduce intraepithelial eosinophil count, but also to improve symptoms, and to lower the occurrence of strictures and the need for dilatations. Future prospective studies are warranted in this area.

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“…MED17238. Correo: natalia.riverasandoval@gmail.com 2 Médico general, graduado de la Universidad de Costa Rica (UCR). Cód.…”

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Esofagitis eosinofílica: principal causa de disfagia en niños y adultos jóvenes

Sandoval¹,

Vega

Quintanilla³

2023

Rev.méd.sinerg.

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La esofagitis eosinofílica es una enfermedad inflamatoria del esófago de carácter crónico que ocurre por una respuesta inmunoalérgica desencadenada en la mayoría de los casos por antígenos alimentarios. Clínicamente, se caracteriza por signos y síntomas relacionados con disfunción esofágica, e histológicamente por inflamación tisular en la cual predominan los eosinófilos. La esofagitis eosinofílica se diagnostica cuando hay síntomas relacionados con disfunción esofágica, como disfagia e impactación alimentaria, presencia de ≥15 eosinófilos por campo de alto poder en la biopsia de la mucosa esofágica, y después de realizar una evaluación exhaustiva de trastornos que pueden causar o contribuir potencialmente a la eosinofilia esofágica. El tratamiento consiste en modificaciones dietéticas, terapias farmacológicas e intervenciones endoscópicas. En 2022, el dupilumab se convirtió en el primer tratamiento para la esofagitis eosinofílica aprobado por la “Food and Drug Administration”. La importancia de que el personal de salud se familiarice con en el manejo de esta enfermedad radica en que, si bien es una enfermedad crónica, su diagnóstico precoz y tratamiento oportuno mejoran la evolución de la enfermedad y la calidad de vida del paciente.

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Eosinophilic esophagitis and esophageal atresia: coincidence or causality?

Cited by 6 publications

References 23 publications

Eosinophilic Esophagitis in Esophageal Atresia: Is It Really a New Disease?

Eosinophilic Esophagitis in Esophageal Atresia: Is It Really a New Disease?

Eosinophilic Esophagitis in Esophageal Atresia

Esofagitis eosinofílica: principal causa de disfagia en niños y adultos jóvenes

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