Eosinophilic esophagitis—A mimic of GERD

Eosinophilic esophagitis: a case report. Effective treatment with systemic corticosteroids for the relapse of the disease

“…Our patient had severe dysphagia and esophageal food impaction induced by esophageal mucosal edema, and it was confirmed by endoscopy. Endoscopic findings have been reported in many reports [5,8,9,11,13,14,16,[18][19][20][21]. Pasha et al [10] reviewed 42 cases of EE in adults and reported that, although some patients had a normal-appearing esophagus (7%), symptomatic patients revealed ulceration, white plaques (5%), absent vascular markings, strictures (10%), and corrugation and linear furrowing (33%), as shown in our case.…”

“…Eosinophilic esophagitis was first described in the 1970s [1][2][3], and, since then, there has been some evidence of escalation in the disease's incidence and prevalence [4][5][6][7][8]. EE appears to have a male predominance, both in children and in adults [7,10,11,22].…”

“…Since then, EE has been recognized with increasing frequency [4][5][6][7][8]. There are many case reports and reviews [6,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], but there are, as yet, no clinical, endoscopic, diagnostic criteria for the disease. Furthermore, there is no standardized treatment for EE, but corticosteroids, either topical or systemic, have proven to be effective [9-11, 15, 19-25].…”

Transient PPI Responsive Esophageal Eosinophilia May Be a Clinical Sub-phenotype of Pediatric Eosinophilic Esophagitis

“…Other esophageal eosinophiliainducing conditions, particularly gastroesophageal reflux (GERD), can be confused with EoE as these conditions can share common symptoms, endoscopic and histological features [1][2][3][4][5][6]. Although GERD was initially thought to cause only mild esophageal eosinophilia (\7 eos/hpf), recent reports have shown that severe esophageal eosinophilia occurs and may resolve with acid-suppression monotherapy using proton-pump inhibitors (PPIs) [2,[7][8][9][10][11][12][13].…”

Otolaryngologists may not be doing enough to diagnose pediatric eosinophilic esophagitis

“…disease (GERD) and treated empirically with acid suppression [1,7,11,16,17]. Eosinophilic esophagitis should be considered in any patient with these signs and symptoms who is unresponsive to maximal acid suppression therapy [1,11,16]. Patients with EE may present to the otolaryngologist with a variety of complaints referred to the upper-aerodigestive tract.…”