Eosinophilic enterocolitis and dermatitis in two horses

Gibson, Katherine; Alders, Robyn

doi:10.1111/j.2042-3306.1987.tb01397.x

Cited by 45 publications

(95 citation statements)

References 18 publications

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“…9,23,66,67 The white blood cell count of most affected horses was normal, but 5 horses had a marked eosinophilia, 9,23,67,71 and a horse with basophilic enterocolitis had a basophilia. 72 Serumal biochemical evidence of liver disease is common in horses with MEED.…”

Section: Clinical and Clinicopathologic Features Of Horses Affected Wmentioning

confidence: 99%

“…Variation in neutrophil numbers may be caused by absorption of endotoxin through diseased intestinal mucosa. 22 Endotoxemia may cause neutropenia 6,7,9,[16][17][18][19][20][21][22][23][24][25] (%) n affected/n reported LPE [57][58][59][60] (%) n affected/n reported MEED 2,9,23,[63][64][65][66][67][68][69][70][71][72][73][74] 6,16,18,23,37 Unlikely to be diagnostic 34 50 6/12 37 Unlikely to be diagnostic 37 GGT, gamma-glutamyl transferase; n, number of horses. a Schumacher, unpublished. through margination and sequestration of circulating neutrophils, and a rebound neutrophilia may result from granulocytic hyperplasia in the bone marrow.…”

Section: Clinical and Clinicopathologic Features Of Horses With Gementioning

confidence: 99%

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Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Schumacher

Edwards

Cohen

2000

Veterinary Internal Medicne

147

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A review of reported cases of inflammatory bowel diseases (IBDs) of horses for which no etiology was identified included cases of granulomatous enteritis (GE), multisystemic eosinophilic epitheliotropic disease (MEED), lymphocytic-plasmacytic enterocolitis (LPE), and idiopathic eosinophilic enterocolitis (EC). The terms EC and MEED were both used to describe a disease in horses characterized by infiltration of intestine and extraintestinal tissues with eosinophils. We use EC to describe IBD characterized by only intestinal infiltration by eosinophils. Horses with GE, MEED, or LPE are usually examined because of weight loss and depression, but horses with EC are usually examined because of signs of abdominal pain. Typically, horses with IBD have low concentrations of serumal proteins, especially albumin, and fail to adequately absorb glucose or xylose. Antemortem diagnosis of IBD can only be made by histologic examination of affected intestine. In some cases, antemortem diagnosis is made from histologic examination of rectal mucosa obtained by biopsy. Suspected causes of IBD in the horse include abnormal immune response to bacterial, viral, parasitic, or dietary antigens. Most horses with IBD do not survive, but horses with EC are more likely than those with LPE, MEED, or GE to respond to treatment. Successful treatments of horses with IBD include resection of grossly affected intestine and administration of corticosteroids.Key words: Eosinophilic enterocolitis; Granulomatous enteritis; Lymphocytic-plasmacytic enterocolitis; Multisystemic eosinophilic epitheliotropic disease.C hronic inflammatory bowel diseases (IBDs) are associated with dysfunction of the gastrointestinal tract due to infiltration of the mucosa and submucosa with populations of eosinophils, plasma cells, lymphocytes, basophils, or macrophages. 1,2 Clinical signs of IBD in the horse include weight loss, dependent edema, and lethargy and are usually associated with protein-losing enteropathy and malabsorption of nutrients, including glucose. Affected horses may have diarrhea or signs of abdominal pain. Signalment, clinical signs, clinicopathologic findings, and postmortem lesions may be highly characteristic of some types of IBD in the horse, but, in general, clinical and gross pathologic features of these diseases are similar, and a final morphologic diagnosis is based on histologic examination. When an etiologic diagnosis of IBD has been reported, mycobacterial 3-12 or parasitic infections, 13,14 or toxins 15 have been identified. The purpose of this report is to describe distinguishing features and discuss possible etiologies of the idiopathic IBDs and to discuss treatment of affected horses. Granulomatous Enteritis (GE)This idiopathic condition was 1st reported in 1974 by Cimprich, 7 who noted the histologic similarity between this disease and Crohn's disease in humans. In our review of the reports of idiopathic GE, we found detailed descriptions of 47 affected horses. 6,7,9,[16][17][18][19][20][21][22][23][24][25] Of these, 32 were Standardbr...

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Section: Clinical and Clinicopathologic Features Of Horses Affected Wmentioning

confidence: 99%

Section: Clinical and Clinicopathologic Features Of Horses With Gementioning

confidence: 99%

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Schumacher

Edwards

Cohen

2000

Veterinary Internal Medicne

147

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“…Of the nearly 50 cases in the literature, only 4 horses survived past 8 months 63,65,66 ; all others were euthanized. These 4 horses were treated with dexamethasone at varying doses.…”

Section: Treatmentmentioning

confidence: 97%

Skin Diseases in Horses

Wobeser

2015

Veterinary Clinics of North America: Equine Practice

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“…ανεπάρκεια λακτάσης στους πώλους 7 , κοκκιωματώ-δης εντεριτιδα 89 , εωσινοφιλική εντεριτιδα 1012 ), την ελλιπή και μη ισορροπημένη διατροφή και τις οξείες ή χρόνιες αιμορραγίες. Οι ηπατοπάθειες δεν προκαλούν, παρά σπά νια, υπολευκωματιναιμια, επειδή η ημιπεριοδος ζωής τους στο άλογο διαρκεί 20 ημέρες 13 . Έτσι απαιτείται κατα στροφή του ηπατικού παρεγχύματος σε ποσοστό μεγαλύ τερο του 80% και για διάστημα μεγαλύτερο των 3 εβδο μάδων, για να παρατηρηθεί η βιοχημική αυτή διαταραχή 13 .…”

Section: ολικές πρωτείνες λευκωματίνες σφαιρίνες λόγος λευκωματινωunclassified

“…Η συγκέντρωση της ουρίας στο αίμα συνήθως εκφράζεται ως άζωτο ουρίας, η συγκέντρωση του οποίου be a massive (more than 80%) and long standing (more than 3 weeks) parenchymal damage 13 .…”

Section: ολικές πρωτείνες λευκωματίνες σφαιρίνες λόγος λευκωματινωunclassified

Reference values of 23 clinically important biochemical parameters in 107 normal pleasure horses residing in northern Greece

Diakakis¹,

Mylonakis

Roubies³

et al. 2018

J Hellenic Vet Med Soc

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The purpose of this study was το establish die reference values of die most useful biochemical parameters from a clinical ροίητ of view in pleasure horses kept in northern greek riding clubs. This biochemical profile included a total of 23 parameters such as Urtai proteins, albumins, globulins, the albumin/globulin ratio, urea nitrogen (BUN), creatinine, glucose, cholesterol, triglycerides, total and direct bilirubin, alkaline phosphatase (ALP), alanine aminotrasferase (ALT), aspartate aminotrasferase (AST), gamma-glutamylotransferase (γ-GT), creatine kinase (CK), lactate dehydrogonase (LDH), sorbitol dehydrogonase (SD), phosphorus (P), calcium (Ca), potassium (K), sodium (Na) and magnesium (Mg). A total of 107 horses, which had been considered clinically normal on historical, clinical and hematological grounds, were sampled. All the measurements were done in the blood serum, applying the relevant methods and reagents which are normally used in the Laboratory of Clinical Diagnosis and Clinical Pathology, School of Veterinary Medicine, A.U.T.. Besides the establishment of the reference interval for each biochemical parameter, all the factors that may cause an abnormal increase or decrease are discussed accordingly.

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Eosinophilic enterocolitis and dermatitis in two horses

Cited by 45 publications

References 18 publications

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Skin Diseases in Horses

Reference values of 23 clinically important biochemical parameters in 107 normal pleasure horses residing in northern Greece

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