Eosinophilic cystitis

Diagnosis and Management of Eosinophilic Cystitis

“…In some patients a mass is palpable during examination of the lower abdomen or digital rectal examination. This was the case in 15 patients [11, 31, 32, 33, 42, 43, 45, 50, 54, 58, 62, 63, 65, 66, 76]. In 2 patients a previously unknown prostatic enlargement was detected [46, 59].…”

“…EC is present in all age groups: in the present study the age–range was 5 days [43]to 87 years [19]. The mean age was 41.6 years.…”

“…We collected 81 articles from the international literature containing one or more cases of patients with EC [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82]. A total of 153 patients were mentioned in these articles.…”

“…The associated etiological factors in EC are listed in table 1, factors mentioned only once were omitted [2, 4, 5, 12, 15, 17, 19, 20, 27, 33, 38, 41, 43, 46, 47, 48, 58, 67, 69]. Some etiological factors are interrelated: most patients with asthma had an allergic constitution, and 10 of them used tranilast medication (antiasthmatic medication only available in Japan) which is clearly a cause of EC (stopping the drug led to cure without further therapy; starting the drug again led to recurrence of EC) [49, 52, 77, 78, 79, 80, 81, 82, 83].…”

N-(3′,4′-Dimethoxycinnamoyl)Anthranillic Acid, an Antiallergic Compound, Induced Eosinophilic Cystitis

“…This agent was originally produced in Japan with the aim of suppressing immunological reac tions and is now used mainly as an antiasthmatic drug. The etiology of eosinophilic cystitis is obscure, but infec tion, chemotactic reaction, parasitic infection and al lergy have all been suggested as possibilities [16]. In our case, a pathogenetic factor presumably altered the im mune reaction in the bladder and the inflammatory response was evoked by an exogenous allergen, such as Tranilast.…”