Eosinophilic Colitis in a Patient With Advanced Transitional Cell Carcinoma of the Bladder: A Paraneoplastic Syndrome?

Uyar, Mehtap Erkmen; Türkay, Cansel; Erbayrak, Mustafa; Köktener, Aslı

doi:10.1097/maj.0b013e31815adeda

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Moreover, 9 of the remaining 32 patients were diagnosed with disseminated cancer and referred to palliative care ( 9 , 38 , 60 , 62 – 64 , 80 , 89 , 93 ). Resolution of peripheral eosinophilia following surgical resection was reported in 18 of the remaining 32 patients, although only ten patients were followed-up between 6 to 30 months ( 15 , 23 , 27 , 33 , 40 – 43 , 61 , 66 , 73 , 77 , 78 , 91 , 92 ). The reappearance of eosinophilia may herald the onset of tumor recurrence.…”

Section: Discussionmentioning

confidence: 99%

Hypereosinophilia in Solid Tumors—Case Report and Clinical Review

2021

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BackgroundRenal cell cancer may cause various paraneoplastic syndromes; however, paraneoplastic hypereosinophilia occurs exceedingly rare. Thus far, only two cases of clear cell renal cell carcinoma (CCRCC) associated with hypereosinophilia have been reported. In this paper, we present a case of paraneoplastic hypereosinophilia associated with renal cell carcinoma and a review of the reported cases of hypereosinophilia in solid tumors.MethodsThe review is based on an electronic literature search performed in the PubMed database in September 2020 with the following key terms: eosinophilia & neoplasm; eosinophilia & cancer; eosinophilia & paraneoplastic syndrome. Papers were included based on screening the titles and/or abstracts. We also included the case of our patient in the analysis.Case presentationA 68-year-old Caucasian female patient with recurrent CCRCC was admitted to our Clinic for exacerbating dyspnea and chest and right upper abdominal pain, accompanied by confusion. Preliminary blood tests showed an increased white blood cell count of 40,770/μl, and an increased eosinophil count of 6,530/μl indicating eosinophilia. Several tests were carried out to rule out the noncancer causes of hypereosinophilia. The temporal appearance of eosinophilia and the recurrence of CCRCC without any other apparent potential causes led to the diagnosis of paraneoplastic hypereosinophilia. Despite treating with high doses of corticosteroids, only a transient decrement in eosinophil count was observed along with further deterioration of the patient’s condition. The patient succumbed to the disease 6 months following the tumor surgery and 2 months after the diagnosis of hypereosinophilia and tumor recurrence.ConclusionOur observations are in agreement with the majority of reports showing that the occurrence of eosinophilia following tumor resection may indicate a poor prognosis, tumor recurrence, and rapid disease progression.

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Section: Discussionmentioning

confidence: 99%

Hypereosinophilia in Solid Tumors—Case Report and Clinical Review

2021

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“…Based on our review, paraneoplastic syndromes are typically associated with aggressive disease. 2,17 TCC-associated necrotizing polymyositis, 5 eosinophilic colitis, 18 and nonislet cell tumour-induced hypoglycaemia 1 have been described. Neurologic syndromes, including Guillain-Barré and Lambert-Eaton myasthenia, have been associated with bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic production of heparin-like anticoagulant in a patient with metastatic transitional cell carcinoma

Fahl

Poon

Badani

et al. 2013

CUAJ

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It has been reported that patients with bladder cancer have widely varying paraneoplastic consequences, including metabolic, dermatologic, myopathic and neurologic disturbances. We report a case of a 52-year-old man with advanced transitional cell carcinoma and liver metastases, who developed a severe coagulopathy following robotic radical cystoprostatectomy due to circulating heparin-like substances prior to onset of liver failure. Heparin-like anticoagulant production is a rare paraneoplastic effect documented in concert with transitional cell carcinoma, breast carcinoma and hematological malignancies.

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“…However, a paraneoplastic syndrome cannot be excluded, given the fact that the patient had a known malignancy. 3 To our knowledge, eosinophilic colonic infiltration as a possible manifestation of lymphoma has never been reported and it might also explain the absent response to the steroid treatments. The patient is currently under the care of our hematologists, with the hope to cure the colitis by treating his lymphoma.…”

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confidence: 88%