Eosinophilic colitis: an update on pathophysiology and treatment

Abstract

Prospective randomized controlled trials addressing the disease natural history, possible preventive methods and effective medical approach and long-term prognosis are required.

Caracterización epidemiológica, clínica y diagnóstica de niños con gastroenteropatía eosinofílica. Estudio retrospectivo de tres instituciones de salud de alta complejidad

“…12 La sintomatología de los DGIE es crónica, variable e inespecífi ca, lo que hace difícil su identificación, generando retrasos en el diagnóstico y llevando a alteración de la calidad de vida del paciente, su estado emocional y entorno social. 13,14,15,16 Econó-micamente genera altos costos al sistema de salud y a los pacientes, secundarios a las múltiples pruebas que se utilizan para la aproximación diagnóstica, el seguimiento estrecho que requieren y el tratamiento de las secuelas. 17,18 Debido a que este grupo de enfermedades fue descrito hace aproximadamente dos décadas, 19 aún no se conoce del todo su comportamiento y curso natural, incluso los datos epidemiológicos son limitados, lo que ha provocado la falta de estandarización del abordaje diagnóstico y terapéutico que prevenga el desarrollo de las secuelas a largo plazo.…”

Hyperhomocysteinemia Lead to Transmural Inflammation of Colon and Increase Severity of Disease in Acetic Acid-Induced Colitis in Rat

“…The result can be a hypersensitivity reaction. Furthermore, eosinophils may contribute to chronic inflammation and fibrosis [42].…”

Eosinophilic Colitis Presenting with Chronic Diarrhea

“…However, there has been an exponential rise in EC yielding 196 cases reported over the past decade. 3 The standardized estimated prevalences of EC were 3.3/100,000. 4 It is characterized by eosinophilic-rich infiltration and peripheral eosinophilia.…”

“…Abscesses of crypts and lymphonodular hyperplasia also may be evident. 3 Eosinophil count in the colon is increased in various disorders such as food allergy, parasitic infections, and inflammatory bowel disease. 1,8 Eosinophils location in the intestines allows ready access for these white blood cells to combat multicellular parasites, likely an evolutionary survival tool.…”

“…Corticosteroids works by inhibit eosinophil growth factors: interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte-macrophage colony-stimulating factor (GM-CSF). 1,3 Antihistamines, mast cell stabilizer, and leukotriene antagonists are other drugs than can be used in the treatment of EC. In this case, corticosteroids were used to inhibit inflammatory responses caused by eosinophils.…”