Eosinophilic chronic rhinosinusitis

Fujieda, Shigeharu; Imoto, Yoshimasa; Kato, Yoshio; Ninomiya, Takahiro; Tokunaga, Tohru; Tsutsumiuchi, Toshiki; Yoshida, Kanano; Kidoguchi, Masanori; Takabayashi, Tetsuji

doi:10.1016/j.alit.2019.07.002

Cited by 180 publications

(149 citation statements)

References 55 publications

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“…5,6 However, the degree of eosinophilia in NPs has increased in Asia in the past 2 decades. [7][8][9] The geographical differences and changes in histological characteristics of Asian NPs may be related to genetic, nutritional, or environmental factors. 10,11 Therefore, compared with phenotyping by presence of NPs, classifying CRS by inflammatory endotypes can improve the accuracy of identifying the underlying pathophysiology and provide guidance for specific treatment.…”

Section: Uncinate Processmentioning

confidence: 99%

Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

Takabayashi

Schleimer²

2020

Journal of Allergy and Clinical Immunology

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111

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Section: Uncinate Processmentioning

confidence: 99%

Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

Takabayashi

Schleimer²

2020

Journal of Allergy and Clinical Immunology

Self Cite

111

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“…Many patients with non-ECRS are cured by antibiotic administration or surgery. However, ECRS forms multiple nasal polyps (NP) in a bilateral nature and tends to relapse even after surgery [1,2]. This disease is relieved by steroid administration, and steroid therapy is considered to be the most effective treatment [3,4].…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis

Gion

Okano

Koyama

et al. 2020

IJMS

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Cross-linking of antigen-specific IgE bound to the high-affinity IgE receptor (FcεRI) on the surface of mast cells with multivalent antigens results in the release of mediators and development of type 2 inflammation. FcεRI expression and IgE synthesis are, therefore, critical for type 2 inflammatory disease development. In an attempt to clarify the relationship between eosinophilic chronic rhinosinusitis (ECRS) and mast cell infiltration, we analyzed mast cell infiltration at lesion sites and determined its clinical significance. Mast cells are positive for c-kit, and IgE in uncinated tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. The number of positive cells and clinicopathological factors were analyzed. Patients with ECRS exhibited high levels of total IgE serum levels and elevated peripheral blood eosinophil ratios. As a result, the number of mast cells with membranes positive for c-kit and IgE increased significantly in lesions forming NP. Therefore, we classified IgE-positive mast cells into two groups: membrane IgE-positive cells and cytoplasmic IgE-positive cells. The amount of membrane IgE-positive mast cells was significantly increased in moderate ECRS. A positive correlation was found between the membrane IgE-positive cells and the radiological severity score, the ratio of eosinophils, and the total serum IgE level. The number of cytoplasmic IgE-positive mast cells was significantly increased in moderate and severe ECRS. A positive correlation was observed between the cytoplasmic IgE-positive cells and the radiological severity score, the ratio of eosinophils in the blood, and the total IgE level. These results suggest that the process of mast cell internalization of antigens via the IgE receptor is involved in ECRS pathogenesis.

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“…CRS can be outlined as a dysfunctional host-environment interaction of the paranasal sinus mucosa [10][11][12][13]. It has been proposed that oxidative stress induced by both environmental and intrinsic stimuli underlies the onset and persistency of CRS.…”

Section: Discussionmentioning

confidence: 99%

Increased Tissue Expression of Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Is Associated with Disease Severity in Chronic Rhinosinusitis with Nasal Polyps

et al. 2020

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Background: The oxidative stress, induced by both environmental and intrinsic stimuli, underlies the onset and persistency of chronic rhinosinusitis (CRS). Scavenger receptors (SRs) are a broad family of transmembrane receptors involved in a dysfunctional host–environment interaction through a reaction with reactive oxygen species (ROS) production. Objective: We hypothesized possible roles of two major SRs in CRS pathology that can translate to clinical phenotypes or histological subtypes: lectin-like oxidized low-density lipoproteins (LDL) receptor-1 (LOX-1) and scavenger receptor class B type 1 (SR-B1). Patients and Methods: We collected ethmoid sinus mucosa specimens and blood samples from patients with CRS with nasal polyps (CRSwNP; n = 31) or CRS without NP (CRSsNP; n = 13) and 19 control subjects. We performed an RT-PCR analysis, ELISA assay, and immunostaining to determine the expressions and distributions of LOX-1 and SR-B1. Results: The CRSwNP group showed a significant increase in LOX-1 mRNA expression compared to the control group. There was no significant difference in SR-B1 mRNA levels among the three groups. The LOX-1 mRNA levels were positively correlated with the sinus computed tomography (CT) scores. Sinus tissue, but not serum samples, showed elevated concentrations of LOX-1 protein in the CRSwNP group versus the control group. The LOX-1 protein distribution was localized in inflammatory cells and vascular endothelial cells. Conclusion: LOX-1 is a major receptor for oxidized low-density lipoprotein produced by oxidative stress. This is the first study to report alterations in LOX-1 expression and production triggered by persistent inflammatory processes in CRSwNP patients. Our findings reveal complex but important roles for SRs that may contribute to the onset of different CRS phenotypes.

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Eosinophilic chronic rhinosinusitis

Cited by 180 publications

References 55 publications

Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis

Increased Tissue Expression of Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Is Associated with Disease Severity in Chronic Rhinosinusitis with Nasal Polyps

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