Eosinophilic aortitis with thoracic aortic aneurysm and rupture in a captive‐born owl monkey

Abstract

Eosinophilic aortitis is a rare condition in animals and humans, and it has been occasionally reported associated with parasitic migration and with a poorly understood complex group of autoimmune vasculitides. Here, we describe a case of eosinophilic aortitis with thoracic aortic aneurysm and rupture in a captive-born owl monkey and discuss the differential diagnoses.

Detection of early myocardial cell death in owl monkeys (Aotus nancymai) using complement component C9 immunohistochemistry in formalin‐fixed paraffin‐embedded heart tissues: A retrospective study

“…The cardiac changes in the owl monkeys are usually accompanied by renal vascular changes with arteriolosclerosis of the small arteries and the afferent arteriole of the renal glomeruli, 5,6 a characteristic lesion of essential arterial hypertension in humans 13,28 . In humans, hypertension can lead not only to cardiac hypertrophy and heart failure, but also to aortic dissection and renal failure, 13 and both conditions previously reported in captive owl monkeys 11,29–31 . Chronic arterial hypertension causes structural and functional changes in the wall of medium and small coronary arteries increasing the stiffness which negatively affect the physiologic function and, consequently, myocardial perfusion 32 .…”

Lipid profile, apolipoproteins A‐1 and B in owl monkeys (Aotus infulatus) in captivity

“…In owl monkeys, left ventricular hypertrophy is more commonly described in the literature, with atherosclerosis being an uncommon postmortem finding, even in animals that suffered sudden death. In owl monkeys, left ventricular hypertrophy has its pathophysiology based on essential hypertension and as a result of chronic action of catecholamines due to captivity stress, 2–7 however, in humans, some studies also suggest the importance of dyslipidemia in the origin of this heart disease 16 …”

“…8,10 In owl monkeys, left ventricular hypertrophy is more commonly described in the literature, with atherosclerosis being an uncommon postmortem finding, even in animals that suffered sudden death. In owl monkeys, left ventricular hypertrophy has its pathophysiology based on essential hypertension and as a result of chronic action of catecholamines due to captivity stress, [2][3][4][5][6][7] however, in humans, some studies also suggest the importance of dyslipidemia in the origin of this heart disease. 16 The owl monkeys evaluated in this work presented lower TC values than those observed in the literature (140 mg/dl ± 32 SD in males and 169 mg/dl ± 49 SD in females 17 and 161 mg/dl ± 53 SD in F I G U R E 1 Distribution between sex and age group of animals with suspect of heart disease (group 2) males and 140 mg/dl ± 39 SD in females 18 ).…”

“…The owl monkey (Aotus infulatus) is a neotropical primate used in several biomedical research, especially in malaria infection trials, which asserts the importance of breeding this species in primatology centers. 1 Among the difficulties encountered in maintaining these animals in captivity, is the incidence of heart diseases such as aortic aneurysm, 2 eosinophilic aortitis, 3 dilated as well as hypertrophic cardiomyopathy and its possible complications such as acute myocardial infarction, [4][5][6] and vascular diseases such as arteriosclerosis of the renal glomeruli associated with concentric left ventricular hypertrophy. 7 In patients with suspected heart disease, plasma lipid concentrations should be regularly monitored, as dyslipidemia is an important risk factor in cardiovascular events.…”