Eosinophilic Annular Erythema Localized to the Palms and the Soles

Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases

“…As stated in the first report of eosinophilic annular erythema (EAE), the entity of EAE was proposed to describe annular skin lesions associated with tissue eosinophilia . To date, 25 cases of EAE have been reported in the English literature . EAE is characterized by the appearance of persistent annular or figurate lesions, a chronic course with recurrent relapse and recalcitrance to various treatments .…”

Annular erythematous plaques on the trunk

“…As the name indicates, the disease is characterized by recurrent annular, polycyclic, or gyrate plaques with central clearing and erythematous border that may turn violaceous with long standing disease. The cutaneous lesions occur predominantly on the trunk and extremities, with possible involvement of the palms and soles . Laboratory tests may be noncontributory although in some cases may show peripheral eosinophilia.…”

“…Laboratory tests may be noncontributory although in some cases may show peripheral eosinophilia. Histopathology is characterized by dense superficial and deep perivascular and interstitial inflammatory infiltrate of lymphocytes and abundant eosinophils . The etiology has not yet been determined, although a possible hypersensitive reaction to an unknown antigen was postulated …”

“…Similar to WS, the cases of EAE have been reported to be associated with various systemic diseases. Underlying neoplasm (prostate and renal carcinoma, thymoma), autoimmune disease (thyroiditis) and infections (chronic borreliosis, chronic hepatitis C) were reported, therefore an exhaustive investigation is required …”

“…As for therapy, many different therapeutic approaches have been tried, including corticosteroids, chloroquine and hydroxychloroquine, cyclosporine, indomethacin, or dapsone . Among these, antimalarial therapy seems to be more effective, although there may be recurrence of the disease after withdrawal of the drug .…”