Eosinophilic angiocentric fibrosis

Abstract

Eosinophilic angiocentric fibrosis of the upper respiratory tract is a rare disorder of unknown aetiology. Despite characteristic histological findings, the aetiology and management of this lesion remain unclear. We describe a case of nasal eosinophilic angiocentric fibrosis and discuss possible demographic and aetiological patterns.

Nasal Cavity Eosinophilic Angiocentric Fibrosis: CT and MR Imaging Findings

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] To the best of our knowledge, only 40 cases of this entity have been reported in the English literature since the entity was first proposed by Roberts and McCann in 1985 1 ; unfortunately, no specific imaging study on this entity was found until now. We reviewed, retrospectively, the CT and MR imaging findings of 6 patients with EAF confirmed by histology.…”

Rare Pathology of Sinonasal Tract; Eosinophilic Angiocentric Fibrosis

“…There has been some evidence that trauma may cause acceleration of disease progression. After surgical resection, EAF showed rapid progression in some cases (2,(8)(9)(10). Our case did not have any symptoms of allergy and and she did not have prior nasal trauma or surgery either.…”

Sinonasal Eosinophilic Angiocentric Fibrosis: A Report of Four Cases and Review of Literature

“…While there are some histopathologic features in common among these diseases, granuloma faciale lacks the 'onion-skin' pattern of collagen whorling around a central vessel that is characteristic of EAF. The debate, therefore, continues as to whether EAF is a mucosal variant of granuloma faciale, or whether they are distinct entities [9,12,18]. Nasal polyps and chronic sinusitis are also included in the differential diagnosis, however, the presence of progressive inflammatory process should warrant further clinical, radiological and histologic evaluation.…”

“…Surgical resection is the treatment of choice, though multiple procedures are often required. Though a possible association between GF and EAF, and WG and EAF have been reported, further case reports of this rare lesion are necessary before the etiology, pathogenesis and management can be clearly defined [1,2,7,8,12,[14][15][16][17][18]23].…”

“…Two years later, Roberts and McCann reported two cases of female patients with an unusual stenosing lesion involving the upper respiratory tract and gave a descriptive diagnosis: eosinophilic angiocenteric fibrosis (EAF) [2]. A review of the English literature reveals 28 additional cases of EAF involving the sinonasal tract have been reported [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. EAF typically presents in young to middle-aged females as a slowly progressive upper airway obstruction in association with a submucosal inflammatory, fibrosing tumor-like lesion.…”