Eosinophilia is a favorable prognostic marker for oral cavity and lip squamous cell carcinoma

Peurala, Emma; Tuominen, Mirella; Löyttyniemi, Eliisa; Syrjänen, Stina; Rautava, Jaana

doi:10.1111/apm.12809

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…OSCC is a malignant tumor with poor prognosis that occurs in the head and neck region, and accounts for 90% of oral cancer cases ( 26 ). Despite the current advances in treatment strategies, the 5-year and 10-year survival rates of patients with OSCC have not significantly improved; therefore, OSCC severely impacts human health ( 27 ). Previous studies have demonstrated that dysregulation of oncogenes and tumor suppressor genes is an important factor in tumorigenesis and development ( 28 - 30 ).…”

Section: Resultsmentioning

confidence: 99%

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Liu

You

2018

Int J Mol Med

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Oral squamous cell carcinoma (OSCC) is a major cancer type in the head and neck region. Recent studies have reported a marked rise in the incidence of OSCC. The present study was performed to better understand the roles that long non-coding RNAs (lncRNAs) serve in OSCC carcinogenesis. The levels of the lncRNA C5orf66 antisense RNA 1 (C5orf66-AS1) and of cytochrome c1 (CYC1) in OSCC tissues and cells were measured through reverse transcription-quantitative polymerase chain reaction. In addition, the levels of associated proteins were analyzed by western blotting, while MTT assay was used to detect the cell proliferation ability. Wound healing and transwell assays were also used to detect the migration and invasion abilities of OSCC cells in the experimental groups, while flow cytometry was applied to analyze cell apoptosis. The findings revealed that the expression of lncRNA C5orf66-AS1 in OSCC tissues and cells was significantly decreased. Overexpression of lncRNA C5orf66-AS1 significantly inhibited the proliferation, invasion and migration ability of OSCC cells, and promoted cell apop-tosis, while lncRNA C5orf66-AS1 downregulation presented the opposite effects. In addition, it was observed that CYC1 was upregulated in OSCC tissues and cells, and was negatively regulated by lncRNA C5orf66-AS1. Notably, CYC1 silencing markedly eliminated the effects of lncRNA C5orf66-AS1 downregulation on OSCC cells. Taken together, these findings indicated that lncRNA C5orf66-AS1 may prevent OSCC progression by inhibiting OSCC cell growth and metastasis via the regulation of CYC1 expression.

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Section: Resultsmentioning

confidence: 99%

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Liu

You

2018

Int J Mol Med

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“…33 The impact of tumor-associated tissue eosinophilia on cancer prognosis is controversial, with opposite results in different studies. 34,35 Eosinophil infiltration of breast tumor is not frequently observed. In a study conducted by Samoszuk and colleagues, the eosinophil peroxidase within or around the tumor has been observed in about 88% of breast cancer, but in none of the benign breast tissue analyzed.…”

Section: Discussionmentioning

confidence: 99%

Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse

Onesti

Josse

Boulet³

et al. 2020

OncoImmunology

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Background: Cancer outcome is associated with circulating immune cells, including eosinophils. Here we analyze the relative eosinophil count (REC) in different breast cancer subtypes. Methods: Stage I-III breast cancer patients were included in the study and classified as REC-high vs low (cutoff 1.5%) or relative lymphocyte count (RLC)-high vs low (cutoff 17.5%). The co-primary endpoints were the breast cancer-specific survival (BCSS) or the time to treatment failure (TTF) in the REC groups. Results: Overall 930 patients were included in the study. We observed a benefit for REC-high vs REC-low in TTF (HR 0.610, 95% CI 0.458-0.812), and in BCSS (HR 0.632, 95% CI 0.433-0.923). Similarly, we observed a better TTF (HR 0.421, 95% CI 0.262-0.677) and BCSS (HR 0.350, 95% CI 0.200-0.614) in RLC-high vs low. A lower relapse rate was observed in the REC-high vs REC-low group (17.1% vs 24.7%, p = 0.005), not confirmed in the multivariate analysis. A lower median REC at baseline and at relapse was observed compared to REC after surgery and during cancer-free follow-up (p < .0001). Conclusions: REC could be a new promising, affordable and accessible predictive and prognostic biomarker in all breast cancer subtypes.

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“…However, another publication showed that the infiltration of eosinophilic tumour is a marker of poor prognosis in patients with OSCC. 15 From the result of this study, the author concluded that the existence of eosinophil in tumour might be a predictor of good outcome. In several neoplasm (such as melanoma, gastric, colorectal, and prostate tumour) eosinophils plays an antitumour effects, in another neoplasm (such as Hodgkin lymphoma) it was correlated with poor outcome.…”

Section: Discussionmentioning

confidence: 83%

The Correlation Between Presence of Eosinophil With Histopathological Subtypes in Nasopharyngeal Carcinoma

Agus¹,

Delyuzar²,

Lubis³

et al. 2021

IJRP

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Background: Nasopharyngeal carcinoma is a malignancy shows squamous differentiation, incidence rate was 5% in Indonesia. Eosinophils are granulocytic leukocytes residing in blood and tissues, has been related as a prognostic indicator for cancers. Whether an increase in eosinophils leading to favorable or unfavorable prognosis still remains controversial and depends on many factors including the type of cancer. Objective: This study was aimed to analyze correlation the presence of eosinophil with histopathologic subtypes in nasopharyngeal carcinoma Material and Methods: This study was analytic, with cross-sectional approach, which were enrolled 72 slides of NPC biopsy, and assessed by accounting eosinophils in 10 high power field (HPF) with 40X magnification. The result with 0 is nothing eosinophil, 1-4 is mild infiltration, 5-19 is moderate infiltration, ≥20 is severe infiltration. Result: There were more males than females, with the highest age group being 51-60 years and the most common histopathological subtype was non-keratinizing squamous cell carcinoma (NKSCC). In NKSCC subtype, the most common eosinophil infiltration category groups were mild and moderate infiltration as many as 25 (39.7%) samples, and in keratinizing squamous cell carcinoma (KSCC) subtype the most common samples were obtained in mild infiltration category group 5 (55.6%) samples. Mann Whitney U test was performed on this variable and obtained p-value 0.025 (p ≤ 0.05). Conclusion:There was correlation between presence of eosinophil with histopathological subtypes in nasopharyngeal carcinoma.

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Eosinophilia is a favorable prognostic marker for oral cavity and lip squamous cell carcinoma

Cited by 15 publications

References 18 publications

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse

The Correlation Between Presence of Eosinophil With Histopathological Subtypes in Nasopharyngeal Carcinoma

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