Eosinophilia in Pulmonary Disorders

Woolnough, Kerry; Wardlaw, Andrew J.

doi:10.1016/j.iac.2015.05.002

Cited by 19 publications

(17 citation statements)

References 71 publications

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“…The number of eosinophils increases in different disorders. [5][6][7][8] Parasitic diseases especially tissue helminthic infections are among the major problems in this context. [9][10][11][12][13][14][15][16][17][18] Fasciolosis is one of the most common zoonotic infections in Iran and in some parts of the world.…”

Section: Discussionmentioning

confidence: 99%

“…Atopic diseases, drug hypersensitivity reactions, connective tissue disorders, malignancies, rarely hypereosinophilic syndromes, monogenic disorders of immune deficiency, pulmonary infections, and eosinophilic gastroenteritis are examples of different disorders in which eosinophilia is observed. [5][6][7][8] Eosinophils dysregulate immune responses related to allergic diseases, such as asthma. Furthermore, this group of immune cells is often conceptualized as destructive end-stage effector mainly related to parasitic diseases especially helminthic infections such as intestinal and tissue nematode infections.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, this group of immune cells is often conceptualized as destructive end-stage effector mainly related to parasitic diseases especially helminthic infections such as intestinal and tissue nematode infections. 6,7 One of the most important laboratory findings in many helminthic infections such as toxocariasis, fasciolosis, ascariasis, hookworm infection, and strongyloidiasis is the high rate of peripheral blood eosinophilia. [9][10][11][12][13][14][15] Moreover, there are some reports about the presence of eosinophilia in protozoan infections such as isosporiasis, sarcocystosis, and dientamoebiasis.…”

Section: Introductionmentioning

confidence: 99%

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Eosinophils and Parasitic Infections

Rahimi¹,

Mohammadzade²,

Khanaliha³

2018

Int J Enteric Pathog

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Background: Eosinophils dysregulate immune responses associated with malignancies, allergic and parasitic diseases especially helminthic infections, though it is infrequently observed with protozoan diseases. Objective: The aim of the present study was to evaluate and compare the percentage of eosinophils in different parasitic diseases at Baqiyatallah Hospital, Tehran, Iran. Materials and Methods: One hundred and 72 samples were obtained from 74 and 98 patients with helminthic and protozoan diseases respectively and evaluated. Direct wet mount and formalin ether concentration were used for intestinal parasites identification. Scotch tape test and serological methods were utilized for diagnosis of Enterobius vermicularis and tissue parasites respectively. Eosinophils were counted and six or more percentages were considered as eosinophilia. Results: In general, in 34 out of 74 helminthic infections (45.9%) and 5 out of 98 protozoan infections (5.1%), an eosinophil level equal or more than 6% was observed. The rate of eosinophilia in helminthic infections were 13/18 (72.2%), 7/11 (63.6%), 3/10 (30%), 2/3 (66.7%), 1/9 (11.11%), 5/13 (38.5%), 3/4 (75%) in the patients with fasciolosis, strongyloidiasis, hymenolepiasis, hookworm infection, enterobiasis, echinococcosis, and trichostrongyliasis, respectively. Concerning the protozoan infections, 3/26(11.5%) and 2/20(10%) of the individuals suffering from giardiasis and blastocystosis showed an eosinophil level higher than normal range, respectively. Conclusion: As expected, helminthic infections especially fasciolosis and strongyloidiasis were the most important infections correlated with eosinophilia. According to available reports, eosinophilia higher than normal range in giardiasis and blastocystosis is not unexpected.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Eosinophils and Parasitic Infections

Rahimi¹,

Mohammadzade²,

Khanaliha³

2018

Int J Enteric Pathog

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“…With the appropriate clinical situation, it may also be important to consider parasitic infections in patients with travel history, such as Ascaris species and Löffler’s syndrome, which is pulmonary eosinophilia in the context of parasitic larvae migrating into the lung 15…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

<p>Chronic eosinophilic pneumonia: clinical perspectives</p>

Crowe¹,

Robinson²,

Sagar³

et al. 2019

TCRM

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Chronic eosinophilic pneumonia (CEP) is an eosinophilic lung disease that is typically diagnosed by a triad of clinical symptoms including pulmonary symptoms, eosinophilia and characteristic radiographic abnormalities. It requires a high index of suspicion given its overlap with other eosinophilic conditions and lack of a specific diagnostic test. The diagnosis is made after careful consideration of other secondary causes of eosinophilia, such as infectious, drugs, or toxic etiologies. CEP generally responds rapidly to treatment, which primarily consists of corticosteroid therapy, but relapses are common. Novel therapies are being explored as more information is being discovered about the pathophysiology of eosinophilic disease processes. Close follow-up is important given the difficulty in weaning patients from glucocorticoids with many patients developing sequelae of chronic glucocorticoid therapy. Therefore, exploring alternative treatments is of upmost importance.

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“…The organs most frequently involved are the lungs, gastrointestinal tract, and skin. [5][6][7] In addition to the nonneoplastic etiologies described above, eosinophilia can be caused by a variety of myeloid, lymphoid, and epithelial neoplasms. Myeloid neoplasms can result in primary eosinophilia because of overproduction of eosinophils from abnormal stem cells.…”

mentioning

confidence: 99%

Blood and Bone Marrow Evaluation for Eosinophilia

Boyer

2016

Archives of Pathology &Amp; Laboratory Medicine

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Evaluation of peripheral blood and bone marrow for an indication of persistent eosinophilia can be a challenging task because there are many causes of eosinophilia and the morphologic differences between reactive and neoplastic causes are often subtle or lack specificity. The purpose of this review is to provide an overview of the differential diagnosis for eosinophilia, to recommend specific steps for the pathologist evaluating blood and bone marrow, and to emphasize 2 important causes of eosinophilia that require specific ancillary tests for diagnosis: myeloproliferative neoplasm with PDGFRA rearrangement and lymphocytevariant hypereosinophilic syndrome.

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Eosinophilia in Pulmonary Disorders

Cited by 19 publications

References 71 publications

Eosinophils and Parasitic Infections

Eosinophils and Parasitic Infections

<p>Chronic eosinophilic pneumonia: clinical perspectives</p>

Blood and Bone Marrow Evaluation for Eosinophilia

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