Eosinophilia associated with a composite lymphoma

Merlio, J.P.; Mascarel, A. De; Astier-Gin, T.; Michenet, Patrick; Beylot, C; Beylot, J

doi:10.1111/j.1365-2559.1991.tb00859.x

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Another possibility is the presence of two monoclonal populations bearing morphological abnormalities, as reported in the very rare composite B cell and T cell lymphoma 32, but much more frequently in AILT 22, 33 in which a monoclonal IgH rearrangement was detected in 20% of cases by Southern blot 34, 35. AIL has been considered as a heterogeneous disease associated with immunodeficiency, in which B cell or T cell clones may develop 22, 33.…”

Section: Discussionmentioning

confidence: 99%

Combined analysis of T cell receptor γ and immunoglobulin heavy chain gene rearrangements at the single‐cell level in lymphomas with dual genotype

Vergier

Dubus

Kutschmar

et al. 2002

The Journal of Pathology

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By prospectively studying immunoglobulin heavy chain gene (IgH) and T cell receptor gamma (TCRgamma) gene rearrangements in 398 lymphoma cases, a dual genotype was observed in 13% of B cell and 11% of T cell lymphomas. According to histological subtype, the highest incidence was observed for mantle cell lymphomas (32%) and lymphoplasmacytic lymphoma (21%) among B cell lymphomas, and for angioimmunoblastic lymphoma (AILT) (46%) and Sézary syndrome (SS) (50%) among T cell lymphomas. To determine whether the dual genotype corresponds to the presence of two distinct monoclonal populations or to the presence of both rearrangements within the same lymphoma cells, single-cell microdissection was used after immunohistochemistry and a single-cell combined IgH and TCRgamma gene analysis was designed after a whole-genome amplification step. This protocol was applied to the study of two nodal B cell lymphomas (one diffuse large B cell lymphoma and one mantle cell lymphoma) and two cutaneous T cell lymphomas (one AILT and one SS). Two cases (SS and mantle cell lymphoma) were true bigenotypic lymphomas, as both IgH and TCRgamma monoclonal rearrangements were detected in the same cells. Conversely, in the diffuse large B cell lymphoma and AILT cases, large CD22+ single cells exhibited only the monoclonal IgH rearrangement but not the TCRgamma gene that was detected in CD3+ single cells. Such an approach allows the identification of true bigenotypic lymphoma among dual genotypic lymphoma. Specific genetic alterations may be further amplified from microdissected cryopreserved material, such as the t(11;14) breakpoint detected in bigenotypic B cells of the mantle cell lymphoma case.

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Section: Discussionmentioning

confidence: 99%

Combined analysis of T cell receptor γ and immunoglobulin heavy chain gene rearrangements at the single‐cell level in lymphomas with dual genotype

Vergier

Dubus

Kutschmar

et al. 2002

The Journal of Pathology

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“…Many cases are associated with viral infection especially with EBV . Of interest the presence of EBV has been demonstrated within one or both of the components . Thus, it could be speculated that virus may induce transformation of two different neoplastic clones.…”

Section: Discussionmentioning

confidence: 99%

Composite cutaneous lymphoma of diffuse large B‐cell lymphoma‐leg type and subcutaneous panniculitis‐like T‐cell lymphoma

et al. 2018

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Composite lymphoma (CL) is a rare disease defined by the occurrence of two distinct lymphomas within a single tissue at the same time. We present the case of an 89-year-old male with a clinical history of immunoglobulin M monoclonal gammopathy of undetermined significance. The patient presented cutaneous eruption of nodules on the right bottom and arm. An excisional biopsy revealed cutaneous infiltration composed of two components. The first one consisted of large B-cells with CD20+/MUM1+/BCL2+ phenotype whereas the second one involved the subcutaneous fat in a panniculitic manner, and was CD3+/CD8+/granzyme B+/TCRβF1+. The final diagnosis was CL of primary cutaneous large B-cell lymphoma-leg type (PCLBCL-leg type) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL). We report and characterize for the first time coexistent PCLBCL-leg type and SPTCL in a patient.

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“…While many of these cases are composed of Hodgkin's and non‐Hodgkin's components, 5–14 others represent different types of non‐Hodgkin's lymphoma from the same lineage 15–18 . Examples of CTBL have also been documented, 19–40 and the components involved in these CTBLs have been shown to vary from one case report to another.…”

Section: Discussionmentioning

confidence: 99%

“…Several hypotheses have been proposed in an attempt to explain how these clonal proliferations co‐exist. For example, the presence of the Epstein‐Barr virus (EBV) has been demonstrated within one or both of the components in a variety of studies, 7,13,19,20,25,37,39 and EBV has been suggested to be a possible etiological agent involved in the development of the B‐cell component within an already‐existing T‐cell lymphoma. Other clinical conditions, such as rheumatoid arthritis and celiac disease, are thought to predispose patients to the development of CTBL.…”

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Clinicopathological analysis of a composite lymphoma containing both T‐ and B‐cell lymphomas

Suefuji

Niino

Arakawa

et al. 2012

Pathology International

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Composite lymphomas (CLs) have been reported in 1-4.7% of all lymphomas, however, CLs containing both T- and B-cell lymphomas (CTBLs) are very rare. Here, we examined the clinical and pathological features of 29 CTBLs. These CTBLs included 21 patients with angioimmunoblastic T-cell lymphoma (AITL) and diffuse large B-cell lymphoma (DLBCL), two with adult T-cell leukemia/lymphoma and DLBCL, one with AITL and Follicular lymphoma, one with Lennert lymphoma and DLBCL, one with subcutaneous panniculitis-like T-cell lymphoma and DLBCL, one with peripheral T-cell lymphoma (PTCL) and DLBCL, one with cutaneous T-cell lymphoma and DLBCL, and one with PTCL and chronic lymphocytic leukemia. Eighteen of 27 patients (67%) were shown to be Epstein-Barr virus (EBV)-encoded RNA-positive in their B-cell lymphoma component. T-cell and B-cell clonality were confirmed by flow cytometry, Southern blot analysis, and/or polymerase chain reaction (PCR). Using Southern blot analysis, clonal immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) rearrangements were detected in 11 of 21 and 15 of 24 cases, respectively. Using PCR analysis, clonal IgH and TCR rearrangements were detected in 7 of 8 and 7 of 7 Southern blot-negative cases, respectively. Our results suggested that PCR analysis was useful in diagnosing CTBL.

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Eosinophilia associated with a composite lymphoma

Cited by 6 publications

References 6 publications

Combined analysis of T cell receptor γ and immunoglobulin heavy chain gene rearrangements at the single‐cell level in lymphomas with dual genotype

Combined analysis of T cell receptor γ and immunoglobulin heavy chain gene rearrangements at the single‐cell level in lymphomas with dual genotype

Composite cutaneous lymphoma of diffuse large B‐cell lymphoma‐leg type and subcutaneous panniculitis‐like T‐cell lymphoma

Clinicopathological analysis of a composite lymphoma containing both T‐ and B‐cell lymphomas

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