Eosinophil Levels, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio in the Cytokine Storm Period of Patients with COVID-19

KOÇ, İbrahim; Özmen, Sevda Ünallı

doi:10.1155/2022/7450739

Cited by 7 publications

(4 citation statements)

References 31 publications

(35 reference statements)

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“…CRP and procalcitonin are increased in both groups at hospital admission, with a slightly higher trend in the group with insulin therapy before hospital admission. Other studies have shown that a higher level of CRP, D-dimers, and decreased lymphocyte number are items included in cytokine storm in COVID-19 disease [ 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Treatment before Hospitalization and Admission Parameters in Patients with Type 2 Diabetes, Obesity, and SARS-CoV-2 Viral Infection

Restea

Mureşan

Voicu

et al. 2023

JPM

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Background: SARS-CoV-2 viral infection is a current and important topic for patients with comorbidities of type 2 diabetes and obesity, associated with increased risk of mortality and morbidity. This study aims to analyze, compare and describe admission parameters in patients with type 2 diabetes, obesity, and SARS-CoV-2 infection based on whether they received insulin therapy before hospital admission. Methods: Our study enrolled patients diagnosed with type 2 diabetes, obesity, and SARS-CoV-2 viral infection, 81 patients without insulin treatment before hospital admission, and 81 patients with insulin at “Gavril Curteanu” Municipal Clinical Hospital of Oradea, Romania, between August 2020 and March 2022. RT-PCR/rapid antigen tests were used for detecting SARS-CoV-2 viral infection. Results: The severe form of COVID-19 was found in 66% of all patients (65% in the group without insulin and 67% in the group with insulin). Oxygen saturation at the time of hospital admission was greater or equal to 90% in 62% of all patients. The most associated comorbidities we founded in this study were: hypertension in 75% of all patients (grade two hypertension 63% in the group without insulin and 64% in the group with insulin), ischemic heart disease in 35% of patients (25% in the group without insulin and 44% in the group with insulin, n = 0.008), heart failure in 9.3% of all patients (8.6% in the group without insulin and 10% in the group with insulin). CRP and procalcitonin are increased in both groups at hospital admission, with a slightly higher trend in the group with insulin therapy before hospital admission. We found that 56% of patients in the group with insulin treatment were with uncontrolled diabetes on admission. Only 10% of patients required a change in antidiabetic treatment with insulin therapy at discharge. In our study, 89% of all patients did not require short-term home oxygen therapy at discharge. Conclusions: Antidiabetic therapy taken before hospital admission did not protect patients against cytokine storm in COVID-19, but is very important in the pathophysiological stage of comorbidities. Paraclinical parameters at hospitalization showed differences in correlation with oral antidiabetic treatment like metformin or insulin therapy. Changing the antidiabetic treatment for a small percentage of patients in the group who had not been receiving insulin therapy before discharge was necessary. It is necessary for future studies to see all changes involved in antidiabetic treatment in patients with diabetes type 2 and obesity after SARS-CoV2 viral infection and its long-term evolution.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic Treatment before Hospitalization and Admission Parameters in Patients with Type 2 Diabetes, Obesity, and SARS-CoV-2 Viral Infection

Restea

Mureşan

Voicu

et al. 2023

JPM

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“…The role of neutrophils and the neutrophil-lymphocyte ratio in predicting COVID-19 outcomes, as discussed by KoÇ and Özmen (2022), provides a valuable context for understanding our results, which suggest that physical activity could have a modulatory effect on these critical immune parameters (10).…”

Section: Discussionmentioning

confidence: 57%

“…The primary aim of this study was to investigate the differences in hematological parameters-specifically, lymphocytes, white blood cells, and platelets-between Moreover, the study's findings regarding white blood cell alterations are particularly relevant considering previous research on the immune response to COVID-19 (10,18).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Levels of Lymphocytes, White Blood Cells, and Platelets in Middle-Aged Active and Inactive Individuals Infected with COVID-19 Hospitalized at Vali-e-Asr Hospital in Birjand City

Rezaei,

Seghatoleslami,

Abedi

2024

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This study aimed to evaluate the impact of physical activity on hematological parameters, specifically lymphocytes, white blood cells (WBC), and platelets, among middle-aged individuals infected with COVID-19. The objective was to determine whether physical activity levels are associated with differences in these key immune markers. A cross-sectional study design was utilized, encompassing 144 middle-aged (35-60 years) COVID-19 patients hospitalized at Vali-e-Asr Hospital in Birjand city. Participants were categorized into active and inactive groups based on their self-reported physical activity levels. Hematological parameters, including lymphocyte, WBC, and platelet counts, were measured and analyzed. Statistical analysis included descriptive statistics and the Mann-Whitney U test to compare differences between groups. The study revealed significant differences in hematological parameters between physically active and inactive patients. Active individuals exhibited higher mean lymphocyte counts (2.48 ± 0.33 vs. 2.47 ± 0.34, p>0.05), WBC (6.55 ± 1.25 vs. 6.52 ± 1.24, p>0.05), and platelet counts (250.50 ± 45.00 vs. 249.95 ± 44.95, p>0.05) compared to their inactive counterparts, although the differences were not statistically significant, suggesting a potential modulatory effect of physical activity on immune markers in COVID-19 patients. Physical activity may have a beneficial impact on the immune response of middle-aged COVID-19 patients, as indicated by the differences in key hematological parameters between active and inactive individuals. However, the observed differences were not statistically significant, underscoring the need for further research to explore the relationship between physical activity and immune function in the context of COVID-19. Future studies should aim to employ longitudinal designs, objective measures of physical activity, and broader population samples to validate and extend these findings.

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“…Some studies have even mentioned absolute/extreme eosinopenia if the eosinophil count was 0 [13,14]. Persistent eosinopenia and lymphopenia were associated with the cytokine storm, which appeared in patients with pulmonary involvement and severe disease [15]. Only a few studies on small samples showed that the severity of the disease was also associated with a decreased count of basophils [16].…”

mentioning

confidence: 99%

White Blood Cells, COVID-19, and Mendelian Randomization

Băicuș

2022

JPM

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Many observational studies have shown an association between the severity of COVID-19 and the different white blood cell counts, most frequently neutrophils, lymphocytes, and eosinophils. The studies aimed to predict the prognosis, and therefore, a causal relationship was unnecessary. However, if we begin to look at these biomarkers as potential therapeutic targets, then causality is essential. Observational studies cannot prove a causal relationship, and randomized trials are not always feasible. In this case, Mendelian randomization studies, considered more valid than observational studies, could add to the arguments for causality. Two Mendelian randomization studies tested for a causal relationship between the number of different white cell populations and COVID-19 severity, but their results are different; therefore, the problem of causality is not settled in this case.

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Eosinophil Levels, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio in the Cytokine Storm Period of Patients with COVID-19

Cited by 7 publications

References 31 publications

Antidiabetic Treatment before Hospitalization and Admission Parameters in Patients with Type 2 Diabetes, Obesity, and SARS-CoV-2 Viral Infection

Antidiabetic Treatment before Hospitalization and Admission Parameters in Patients with Type 2 Diabetes, Obesity, and SARS-CoV-2 Viral Infection

Investigating the Levels of Lymphocytes, White Blood Cells, and Platelets in Middle-Aged Active and Inactive Individuals Infected with COVID-19 Hospitalized at Vali-e-Asr Hospital in Birjand City

White Blood Cells, COVID-19, and Mendelian Randomization

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