Eosinophil-Derived Neurotoxin in Childhood Asthma: Correlation With Disease Severity

Kim, Chang-Keun; Callaway, Zak; Fletcher, Rachel; Koh, Young Yull

doi:10.3109/02770901003792833

Cited by 48 publications

(57 citation statements)

References 31 publications

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“…It has been suggested that the secretory activity of eosinophils - a combination of concentration of eosinophils and their propensity to release degranulation products - may be a key marker of disease activity and is more accurately measured by eosinophil degranulation products such as EDN and ECP [135]. Kim et al [136] found significant differences in EDN and ECP levels in asthmatics during both acute and stable phases when compared to controls. Thus, EDN, along with ECP, may aid in the diagnosis of asthma.…”

Section: Introductionmentioning

confidence: 99%

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Infection, eosinophilia and childhood asthma

Kim¹,

Callaway²,

Fujisawa

2012

Asia Pacific Allergy

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There is a growing list of viruses and bacteria associated with wheezing illness and asthma. It is well known that a few of these pathogens are strongly associated with wheezing illness and asthma exacerbations. What is not known is if early childhood infections with these pathogens cause asthma, and, if so, exactly what are the pathophysiologic mechanisms behind its development. The current consensus is respiratory infection works together with allergy to produce the immune and physiologic conditions necessary for asthma diasthesis. One link between respiratory infection and asthma may be the eosinophil, a cell that plays prominently in asthma and allergy, but can also be found in the body in response to infection. In turn, the eosinophil and its associated products may be novel therapeutic targets, or at the very least used to elucidate the complex pathophysiologic pathways of asthma and other respiratory illnesses. Together or separately, they can also be used for diagnosis, treatment and monitoring. The optimal care of a patient must take into consideration not only symptoms, but also the underlying disease mechanisms.

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Section: Introductionmentioning

confidence: 99%

“…Thus, EDN, along with ECP, may aid in the diagnosis of asthma. It has been suggested by several groups that EDN is more useful than ECP in evaluating disease severity [136-138]. This may partially be due to EDN's recoverability, as ECP is a sticky and more highly charged protein [129].…”

Section: Introductionmentioning

confidence: 99%

Infection, eosinophilia and childhood asthma

Kim¹,

Callaway²,

Fujisawa

2012

Asia Pacific Allergy

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“…Therefore eosinophil granule protein and EDN released by eosinophils, and eotaxin-3 have been studied as other possible biomarkers of EoE. Blood, urine or tissue levels of eosinophil granule proteins and EDN are elevated in eosinophilic associated diseases 2-6. However, information regarding localization of EDN in the diseased tissues has not been available.…”

Section: Discussionmentioning

confidence: 99%

Marked Deposition of Eosinophil-Derived Neurotoxin in Adult Patients With Eosinophilic Esophagitis (Am J Gastroenterol 2010;105:298-307)

2010

J Neurogastroenterol Motil

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“…It has been suggested that the secretory activity of eosinophils – a combination of the concentration of eosinophils and their propensity to release degranulation products – may be a key marker of disease activity and is more accurately measured by eosinophil degranulation products such as EDN and ECP [107]. Kim et al [108] found significant differences in EDN and ECP levels in asthmatics during both acute and stable phases when compared with controls. Thus, EDN, along with ECP, may aid in the diagnosis of asthma.…”

Section: The Role Of Eosinophilia In Asthma Development/exacerbationmentioning

confidence: 99%

“…Thus, EDN, along with ECP, may aid in the diagnosis of asthma. It has been suggested by several groups that EDN is more useful than ECP in evaluating disease severity [108,109,110]. This may partially be due to the recoverability of EDN, as ECP is a sticky and more highly charged protein [101].…”

Section: The Role Of Eosinophilia In Asthma Development/exacerbationmentioning

confidence: 99%

Respiratory Viruses, Eosinophilia and Their Roles in Childhood Asthma

Callaway¹,

Kim²

2010

Int Arch Allergy Immunol

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With the advent of highly sensitive and specific screening of respiratory specimens for viruses, new viruses are discovered, adding to the growing list of those associated with wheezing illness and asthma exacerbations. It is not known whether early childhood infections with these viruses cause asthma, and, if so, what exactly are the pathophysiologic mechanisms behind its development. The current consensus is that respiratory viral infection works together with allergy to produce the immune and physiologic conditions necessary for asthma diasthesis. One link between viruses and asthma may be the eosinophil, a cell that plays a prominent role in asthma and allergy, but can also be found in the body in response to viral infection. In turn, the eosinophil and its associated products may be novel therapeutic targets, or at the very least, used to elucidate the complex pathophysiologic pathways of asthma and other respiratory illnesses. Together or separately, they can be used for diagnosis, treatment and monitoring. Not only symptoms, but also the underlying disease mechanisms must be taken into consideration for the optimal care of a patient.

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Eosinophil-Derived Neurotoxin in Childhood Asthma: Correlation With Disease Severity

Abstract: These findings suggest that serum EDN is a useful marker for identifying disease activity in children with asthma. EDN levels may better reflect disease severity than ECP levels or total eosinophil counts.

Cited by 48 publications

References 31 publications

Infection, eosinophilia and childhood asthma

Infection, eosinophilia and childhood asthma

Marked Deposition of Eosinophil-Derived Neurotoxin in Adult Patients With Eosinophilic Esophagitis (Am J Gastroenterol 2010;105:298-307)

Respiratory Viruses, Eosinophilia and Their Roles in Childhood Asthma

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