Eosinophil Degranulation Patterns in Nasal Polyposis: An Ultrastructural Study

Armengot-Carceller, Miguel; Garín, L; Cardá, Carmen

doi:10.2500/ajra.2009.23.3357

Cited by 35 publications

(22 citation statements)

References 16 publications

(27 reference statements)

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“…More than 20 years ago, Hellquist reported that the edematous eosinophilic type accounted for 86% of all polyps in Sweden. Therefore, eosinophils are probably the most common and important inflammatory cells in the pathogenesis of polyps . It has been well accepted that 1 of the most common histological features of nasal polyps is eosinophilia in the mucosa and submucosa .…”

Section: Resultsmentioning

confidence: 99%

Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement

Lou

Zhang

Bachert

et al. 2018

Int Forum Allergy Rhinol

162

157

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BackgroundTissue eosinophils are characteristic of inflammation in most but not all patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and may be useful for defining subgroups and making treatment choices. However, no consistent diagnostic criteria for CRSwNP with eosinophilic inflammation have been established.MethodsRelated literature review was performed and current developments in the diagnosis of eosinophilic CRSwNP were summarized. Details in histopathology, definition of tissue eosinophilia, eosinophil as an indicator of disease recurrence, eosinophilic shift, and related biomarkers in CRSwNP are included in this review article.ResultsMucosal eosinophilia exhibits significant geographic and ethnic differences and may increase over time. Tissue eosinophilia can be defined using a cutoff value based on reference values from healthy mucosa, but typical disease‐specific values should also be employed to increase sensitivity and specificity for clinical use. Recent developments highlight the diagnostic criteria for eosinophilic CRSwNP based on cluster analysis, which were also associated with clinical outcomes. Additionally, some promising eosinophil‐relevant biomarkers, such as eosinophilic cation protein and interleukin 5 (IL‐5), may be clinically applied as diagnostic or predictive tools for CRSwNP in the future.ConclusionSinonasal tissue eosinophilia is present in a majority of CRSwNP patients but is currently more common in the West than in the East. Cutoff values of eosinophils as the diagnostic criteria of eosinophilic CRSwNP are subject to change with geographic and ethnic differences over time. It will be important to identify validated eosinophil‐related biomarkers in different continents/countries for future research and for the introduction of precision medicine.

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Section: Resultsmentioning

confidence: 99%

Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement

Lou

Zhang

Bachert

et al. 2018

Int Forum Allergy Rhinol

162

157

View full text Add to dashboard Cite

show abstract

“…13,52 Exocytosis is an uncommon in vivo eosinophil degranulation event, but can be observed during in vitro interaction of eosinophils with different parasitic helminths 72 and environmental fungi 73 or after in vitro stimulation with high concentration of TNF-. 9 Cytolysis and PMD are the most frequent modes of eosinophil degranulation in vivo, being well documented in numerous human diseases such as nasal polyposis, [76][77][78] allergic rhinitis, 77,79 atopic dermatitis, 80 asthma, 77 ulcerative colitis, 77 Crohn's disease, 77 shigellosis, 81 cholera, 82 gastric carcinoma, 83 and eosinophilic esophagitis. 59 Interestingly, human eosinophils can show different degranulating patterns in vivo, in response to a specific eosinophilic disease or condition.…”

Section: Eosinophil Specific Granules Are Membranous Compartmentalizementioning

confidence: 99%

Contemporary understanding of the secretory granules in human eosinophils

Melo

Weller²

2018

Journal of Leukocyte Biology

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Eosinophil secretory (specific) granules have a unique morphology and are both a morphologic hallmark of eosinophils and fundamental to eosinophil-mediated responses. Eosinophil mediators with multiple functional activities are presynthesized and stored within these granules, poised for very rapid, stimulus-induced secretion. The structural organization and changes of eosinophil specific granules are revealing in demonstrating the complex and diverse secretory activities of this cell. Here, we review our current knowledge on the architecture, composition, and function of eosinophil specific granules as highly elaborated organelles able to produce vesiculotubular carriers and to interplay with the intracellular vesicular trafficking. We reconsider prior identifications of eosinophil cytoplasmic granules, including "primary," "secondary," "microgranules," and "small granules"; and consonant with advances, we provide a contemporary recognition that human eosinophils contain a single population of specific granules and their developmental precursors and derived secretory vesicles.

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“…The pathophysiology of tissue eosinophilia is incompletely known, but Th2 cytokines including IL-5 and eotaxins play an indispensable role in eosinophil-selective accumulation, similar to other allergic diseases [12, 18]. Of note, approximately 30 % of tissue eosinophils in CRSwNP exhibit ultrastructural evidence of cytolysis [19]. …”

Section: Lessons From Chronic Rhinosinusitis: Pathogenesis Of Eosinopmentioning

confidence: 99%

Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation

Ueki

Tokunaga

Fujieda

et al. 2016

Curr Allergy Asthma Rep

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The traditional paradigm of eosinophils as end-stage damaging cells has mainly relied on their release of cytotoxic proteins. Cytokine-induced cell survival and secretion of granular contents from tissue-dwelling eosinophil are thought to be important mechanisms for eosinophilic inflammatory disorders, although the occurrence of cytolysis and its products (i.e., free extracellular granules) has been observed in affected lesions. Recent evidence indicates that activated eosinophils can exhibit a non-apoptotic cell death pathway, namely extracellular trap cell death (ETosis) that mediates the eosinophil cytolytic degranulation. Here, we discuss the current concept of eosinophil ETosis which provides a new look at eosinophilic inflammation. Lessons from eosinophilic chronic rhinosinusitis revealed that ETosis-derived DNA traps, composed of stable web-like chromatin, contribute to the properties of highly viscous eosinophilic mucin and impairments in its clearance. Intact granules entrapped in DNA traps are causing long-lasting inflammation but also might have immunoregulatory roles. Eosinophils possess a way to have post-postmortem impacts on innate immunity, local immune response, sterile inflammation, and tissue damage.

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Eosinophil Degranulation Patterns in Nasal Polyposis: An Ultrastructural Study

Cited by 35 publications

References 16 publications

Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement

Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement

Contemporary understanding of the secretory granules in human eosinophils

Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation

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