Eosinophil Apoptosis Induced by Fungal Immunomodulatory Peptide-fve via Reducing IL-5α Receptor

Hsieh, Chang‐Wei; Lan, Joung Liang; Meng, Qiu; Cheng, Ya Wen; Huang, Huei Mei; Tsai, Jaw Ji

doi:10.1016/s0929-6646(09)60214-x

Cited by 21 publications

(19 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were then followed by several studies investigating the anti-allergic effect of FIP-fve against allergen-induced airway diseases (Hsieh et al, 2007; Lee et al, 2013). Hsieh et al (2007) investigated the effect of FIP-fve on the survival of eosinophils isolated and purified from allergic asthmatic patients in the presence of IL-5.…”

Section: Biological Activities Of F Velutipesmentioning

confidence: 95%

“…Hsieh et al (2007) investigated the effect of FIP-fve on the survival of eosinophils isolated and purified from allergic asthmatic patients in the presence of IL-5. The study indicated that FIP-fve induced apoptosis of eosinophils in the presence of IL-5 (which is a survival factor of eosinophils), thereby preventing eosinophils from undergoing necrosis.…”

Section: Biological Activities Of F Velutipesmentioning

confidence: 99%

See 1 more Smart Citation

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

et al. 2016

View full text Add to dashboard Cite

Flammulina velutipes (enoki, velvet shank, golden needle mushroom or winter mushroom), one of the main edible mushrooms on the market, has long been recognized for its nutritional value and delicious taste. In recent decades, research has expanded beyond detailing its nutritional composition and delved into the biological activities and potential health benefits of its constituents. Many bioactive constituents from a range of families have been isolated from different parts of the mushroom, including carbohydrates, protein, lipids, glycoproteins, phenols, and sesquiterpenes. These compounds have been demonstrated to exhibit various biological activities, such as antitumour and anticancer activities, anti-atherosclerotic and thrombosis inhibition activity, antihypertensive and cholesterol lowering effects, anti-aging and antioxidant properties, ability to aid with restoring memory and overcoming learning deficits, anti-inflammatory, immunomodulatory, anti-bacterial, ribosome inactivation and melanosis inhibition. This review aims to consolidate the information concerning the phytochemistry and biological activities of various compounds isolated from F. velutipes to demonstrate that this mushroom is not only a great source of nutrients but also possesses tremendous potential in pharmaceutical drug development.

show abstract

Section: Biological Activities Of F Velutipesmentioning

confidence: 95%

Section: Biological Activities Of F Velutipesmentioning

confidence: 99%

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Fve was able to induce mitogenic proliferation of human peripheral mononuclear cells (PBMCs) and enhance mRNA transcription of interleukin (IL)-2 and interferon (IFN)-c in vitro (Ko et al 1995;Wang et al 2004). Administration of Fve with allergens either intraperitoneally, orally, or intranasally inhibited allergeninduced systemic anaphylactic responses (Ko et al 1995), food allergic reactions (Hsieh et al 2003), or allergic airway inflammation (Liu et al 2003;Liu and Tsai 2005;Hsieh et al 2007) in vivo, respectively. Recently, Fve has also been shown to exhibit potent adjuvant properties that enhanced the immunogenicity of the human papillomavirus type-16 (HPV-16) E7 oncoprotein and conferred increased antitumor effects against the inoculation of HPV-16 E7-expressing TC-1 cells in a mouse model (Ding et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Characterization of an immunomodulatory Der p 2-FIP-fve fusion protein produced in transformed rice suspension cell culture

Kuo

Chen

et al. 2011

Transgenic Res

View full text Add to dashboard Cite

Der p 2, a major allergen of Dermatophagoides pteronyssinus mites, is one of the most clinically relevant allergens to allergic patients worldwide. FIP-fve protein (Fve) from the golden needle mushroom (Flammulina velutipes) is an immunomodulatory protein with potential Th1-skewed adjuvant properties. Here, we produced and immunologically evaluated a Der p 2-Fve fusion protein as a potential immunotherapeutic for allergic diseases. Using an inducible expression system in cultured rice suspension cells, the recombinant Der p 2-Fve fusion protein (designated as OsDp2Fve) was expressed in rice cells under the control of an α-amylase gene (αAmy8) promoter and secreted under sucrose starvation. OsDp2Fve was partially purified from the cultured medium. The conformation of Der p 2 in OsDp2Fve remains intact as reflected by its unaltered allergenicity, as assessed by human IgE ELISA and histamine release assays, compared to non-fusion Der p 2 protein. Furthermore, the Fve protein expressed in OsDp2Fve retains its in vitro lymphoproliferative activity but loses its hemagglutination and lymphoagglutination effects compared to the native protein. Notably, in vivo evaluation showed that mice administered with OsDp2Fve possessed an enhanced production of Der p 2-specific IgG antibodies without potentiating the production of Der p 2-specific IgE and Th2 effector cytokines in comparison with mice co-administered with native Fve and Der p 2 proteins. These results suggest that the recombinant Der p 2-Fve fusion protein produced in rice suspension cell cultures has a great potential for allergy immunotherapy.

show abstract

“…It was also reported that the immunoprophylatic effects of FVE in Th2-mediated allergic anaphylaxis were associated with the ability of FVE to enhance activation of IFN-γ-releasing Th1 cells and inhibit IL-5-mediated survival of eosinophils [9,11]. IFN-γ was believed to play a key role in FVE-mediated immune response, leading to subsequent priming of the Th1 differentiation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma

Chang

Hsieh

Yeh

et al. 2010

International Immunopharmacology

View full text Add to dashboard Cite

Eosinophil Apoptosis Induced by Fungal Immunomodulatory Peptide-fve via Reducing IL-5α Receptor

Cited by 21 publications

References 29 publications

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

Characterization of an immunomodulatory Der p 2-FIP-fve fusion protein produced in transformed rice suspension cell culture

Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma

Contact Info

Product

Resources

About