Eosinopenia Induced by Anti-IL-5 Antibody, but Not Eimeria nieschulzi Extract, Increases Susceptibility to Experimental Amebic Abscess of the Liver (EAAL) in Gerbils

López-Osuna, M; Cárdenas, Guadalupe; Arellano, Jorge; Fernández-Díez, Jorge; Kretschmer, R

doi:10.1016/s0188-4409(02)00358-2

Cited by 2 publications

(1 citation statement)

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“…We did not observe NK cells in physical contact with amoebas. Furthermore, although eosinophils reduced the severity of amoebic liver formation in gerbils (34), in our study they were less numerous in the ulcer than in the normal intestine. Similarly, although mast cells were abundant in a model of intestinal amoebiasis (33,35), we did not observe any difference in eosinophil numbers between normal and inflamed intestine.…”

Section: Discussioncontrasting

confidence: 72%

Immunohistochemical characterization of human fulminant amoebic colitis

Ventura‐Juárez

Barba-Gallardo

Muñoz-Fernández

et al. 2007

Parasite Immunology

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In cases of fulminant amoebic colitis we have determined the interactions between Entamoeba histolytica trophozoites and immune cells in order to better understand the pathophysiology of amoebic colitis. Eleven specimens of amoebic colitis and five specimens of colon without amoebic lesions were studied. Trophozoites and immune cells were located by topographic stains, histochemistry and immunohistochemistry. Trophozoites were seen in both damaged and undamaged areas of the colonic mucosa. Specimens of fulminant amoebic colitis showed: (a) an increase in IgA+, IgG+ B cells and neutrophils; (b) a reduction in IgM+ B cells, CD8+ T cells, macrophages, eosinophils and mast cells; and (c) no change in the number of NK and CD4+ T cells. The cellular infiltrate in amoebic colitis may represent the combined effects of amoebic monocyte locomotion inhibitory factor and switching of IgM+ B cells to IgG+ and IgA+ plasma cells, induced by amoebic antigens. Tissue damage in the absence of trophozoites may result from ischaemia or host immune responses.

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Section: Discussioncontrasting

confidence: 72%