Enzymology of ranitidine metabolism in isolated hepatocytes from dog

Cloning, Sequencing, and Tissue-Dependent Expression of Flavin-Containing Monooxygenase (FMO) 1 and FMO3 in the Dog

“…The involvement of FMO in drug metabolism in the dog has been confirmed by the FMO-dependent N-oxidation of ABT-418 (Rodrigues et al, 1995), ranitidine (Cross et al, 1990), and L-775,606 (Prueksaritanont et al, 2000) as being the main pathway of metabolism for these substrates in the dog liver. Furthermore, dog hepatocytes were shown to metabolize benzidamine, a substrate for FMO1, very efficiently (Ubeaud et al, 1999).…”