Enzymes in riboflavin biosynthesis: Potential antibiotic drug targets

Jaroensuk, Juthamas; Chuaboon, Litavadee; Kesornpun, Chatchai; Chaiyen, Pimchai

doi:10.1016/j.abb.2023.109762

Cited by 4 publications

(1 citation statement)

References 101 publications

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“…The enzymes involved in its synthesis in bacteria represent an intriguing target as they are not found in mammalian cells, which import riboflavin rather than synthesize it. Possible targets include GTP cyclohydrolase II (GCH II), lumazine synthase (LS), riboflavin synthase (RFS), FAD synthetase (FADS), and FMN riboswitch, as reviewed in 2023 . A range of early stage inhibitors are described in this review, including the example of ribocil C ( 96 ) (Figure ), which is a highly selective inhibitor of the FMN riboswitch. − The Hergenrother eNTRy rules , were applied to attempt to improve G–ve uptake, producing more active ribocil C-PA ( 97 ) .…”

Section: Compounds With New Antibacterial Modes Of Actionmentioning

confidence: 99%

A Review of Antibacterial Candidates with New Modes of Action

Butler,

Vollmer,

Goodall

et al. 2024

ACS Infect. Dis.

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Section: Compounds With New Antibacterial Modes Of Actionmentioning

confidence: 99%

A Review of Antibacterial Candidates with New Modes of Action

Butler,

Vollmer,

Goodall

et al. 2024

ACS Infect. Dis.

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Unraveling bacterial stress responses: implications for next-generation antimicrobial solutions

Avci

2024

World J Microbiol Biotechnol

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The accelerated spread of antimicrobial-resistant bacteria has caused a serious health problem and rendered antimicrobial treatments ineffective. Innovative approaches are crucial to overcome the health threat posed by resistant pathogens and prevent the emergence of untreatable infections. Triggering stress responses in bacteria can diminish susceptibility to various antimicrobials by inducing resistance mechanisms. Therefore, a thorough understanding of stress response control, especially in relation to antimicrobial resistance, offers valuable perspectives for innovative and efficient therapeutic approaches to combat antimicrobial resistance. The aim of this study was to evaluate the stress responses of 8 different bacteria by analyzing reporter metabolites, around which significant alterations were observed, using a pathway-driven computational approach. For this purpose, the transcriptomic data that the bacterial pathogens were grown under 11 different stress conditions mimicking the human host environments were integrated with the genome-scale metabolic models of 8 pathogenic species (Enterococcus faecalis OG1R, Escherichia coli EPEC O127:H6 E2348/69, Escherichia coli ETEC H10407, Escherichia coli UPEC 536, Klebsiella pneumoniae MGH 78578, Pseudomonas aeruginosa PAO1, Staphylococcus aureus MRSA252, and Staphylococcus aureus MSSA476). The resulting reporter metabolites were enriched in multiple metabolic pathways, with cofactor biosynthesis being the most important. The results of this study will serve as a guide for the development of antimicrobial agents as they provide a first insight into potential drug targets.

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Engineering the substrate channeling interface between the heterologous modules for a highly efficient FAD synthetase

Feng,

Li,

et al. 2024

Biochemical Engineering Journal

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Enzymes in riboflavin biosynthesis: Potential antibiotic drug targets

Cited by 4 publications

References 101 publications

A Review of Antibacterial Candidates with New Modes of Action

A Review of Antibacterial Candidates with New Modes of Action

Unraveling bacterial stress responses: implications for next-generation antimicrobial solutions

Engineering the substrate channeling interface between the heterologous modules for a highly efficient FAD synthetase

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