Enzymes in removal of pharmaceuticals from wastewater: A critical review of challenges, applications and screening methods for their selection

Stadlmair, Lara F.; Letzel, Thomas; Drewes, Jörg E.; Graßmann, Johanna

doi:10.1016/j.chemosphere.2018.04.142

Cited by 90 publications

(51 citation statements)

References 145 publications

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“…The advantages and disadvantages of several available techniques (wastewater treatment plants (WWTPs) with activated sludge treatment, WWTPs with coagulation, constructed wetlands, chlorination, membrane bioreactors, micro-, ultra-and nanofiltration, reverse osmosis, ozonation, photocatalysis, advanced oxidation processes (AOPs, for example, photocatalysis, Fenton and photo-Fenton), adsorption and activated powder) have recently been presented by Patel et al (Patel et al 2019) according to the elimination of pharmaceuticals (in terms of efficiency, toxicity of products, cost, technical operation, among others). The current reviews devoted to techniques for the reduction in pharmaceuticals from wastewaters are obtained (Shi et al 2017;Tiwari et al 2017;Stadlmair et al 2018;de Oliveira et al 2020;Femina Carolin et al 2020;Shah and Shah 2020). What should be stressed is that there is a need for a standardization of the criteria of evaluation of advanced techniques, because the report lacks important information (Fischer et al 2019).…”

Section: Treatment Of Waters By Advanced Techniquesmentioning

confidence: 99%

How to decrease pharmaceuticals in the environment? A review

Caban

Stepnowski

2021

Environ Chem Lett

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The global problem of the presence of human and veterinary pharmaceuticals in the environment is under investigation. Despite the increase in the knowledge of its sources, fates and impacts, the assessment of risks and the derived prevention actions are limited to single cases. The predicted increasing trend in the usage of pharmaceuticals forces the various parties involved to think about comprehensive mitigation actions. There are many areas of daily human life and industrial operations where such actions should take place. Thereby, in the presented review, such actions were summarized and divided into the following groups: A. design, synthesis and production of pharmaceuticals, B. prescription, sales and waste handling, C. control of the sources with advanced technologies. As the total amount of proposed actions was found to be quite high, a ranking according to the term of effects was proposed using the pyramid of needs. The advantages of actions taken in the first steps of the pharmaceutical life cycle (acting on the upstream) over end-of-pipe actions and the application of advanced technologies (the downstream option) were discussed, with reference to expert opinions.

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Section: Treatment Of Waters By Advanced Techniquesmentioning

confidence: 99%

How to decrease pharmaceuticals in the environment? A review

Caban

Stepnowski

2021

Environ Chem Lett

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“…The effect and the fate of pharmaceuticals on the human health and wildlife are still unclear. Though, it has been found these compounds potential to cause aquatic toxicity, genotoxicity, endocrine disruption and development of resistance in pathogenic microbes (Couto, Lange, & Amaral, 2019;de Oliveira et al, 2019;Dogan et al, 2020;Dordio et al, 2017;Stadlmair et al, 2018).…”

Section: Clay Minerals and Hs Composites For Pharmaceutical Treatmentmentioning

confidence: 99%

Clay minerals and humic substances as landfill closure covering material constituents: first studies

Burlakovs¹,

Pilecka-Ulcugaceva²,

Grīnfelde³

et al. 2020

Research for Rural Development

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Soil and groundwater as the leachate may contaminate surrounding watersheds, thus different pollutants from closed dumps and landfills pose significant risks to human health and ecology. Pollution may lead to soil and water degradation however it might be diminished through sustainable dump site closure projects and processual management. Several decades of clays and clay minerals studies lead to modified clay composites concept that is one of the potential promising solutions for building the landfill covering material and serve as capping biocover layer at the same time. As humic substances are constituents of soil organic matter, pollutants can be sorbed on the surfaces of complex molecules. This kind of humic acid-clay mineral composite materials thus might become as low cost building material component - covering material. Construction of such layer are to be performed as a combination of clay-humic composites and landfill mined fine fraction of waste with small amendment of natural soil. Several hypotheses that are already proven has to be mentioned: a) Clay minerals produce composites with humic substances; 2) Clay-humic complexes reduce through sorption both organic and inorganic pollutants; 3) Low risk of toxic byproducts from landfill mined waste fine fraction can be the problem; 4) Such composites mostly would trap toxic contaminants (e.g., pharmaceuticals) found in reworked fine fraction of waste. The aim of the work is to provide alternative solution for landfill closure by giving theoretical considerations from multidisciplinary knowledge of environmental engineering, chemistry and waste management.

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“…In this context, biological methods of pollutant removal concerning use of microorganisms and/or enzymes seem to be of particular interest [11]. Particularly, enzymes such as laccases and tyrosinases, manganese, horseradish, lignin, and phenol peroxidases hold a promising role to mitigate any kinds of contamination including a wide range of phenolic compounds in a specific, easy-to-monitor, and highly controllable manner [12]. Enzyme-based processes offer also many other advantages such as low energy input, low toxicity, ability to operate under mild conditions, reduced amount of sludge, and by-product generation [13,14].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Wastewater Treatment by Immobilized Enzymes

et al. 2021

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Purpose of Review In the presented review, we have summarized recent achievements on the use of immobilized oxidoreductases for biodegradation of hazardous organic pollutants including mainly dyes, pharmaceuticals, phenols, and bisphenols. In order to facilitate process optimization and achievement of high removal rates, effect of various process conditions on biodegradation has been highlighted and discussed. Recent Findings Current reports clearly show that immobilized oxidoreductases are capable of efficient conversion of organic pollutants, usually reaching over 90% of removal rate. Further, immobilized enzymes showed great recyclability potential, allowing their reuse in numerous of catalytic cycles. Summary Collected data clearly indicates immobilized oxidoreductases as an efficient biocatalytic tools for removal of hazardous phenolic compounds, making them a promising option for future water purification. Data shows, however, that both immobilization and biodegradation conditions affect conversion efficiency; therefore, process optimization is required to achieve high removal rates. Nevertheless, we have demonstrated future trends and highlighted several issues that have to be solved in the near-future research, to facilitate large-scale application of the immobilized oxidoreductases in wastewater treatment.

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Enzymes in removal of pharmaceuticals from wastewater: A critical review of challenges, applications and screening methods for their selection

Cited by 90 publications

References 145 publications

How to decrease pharmaceuticals in the environment? A review

How to decrease pharmaceuticals in the environment? A review

Clay minerals and humic substances as landfill closure covering material constituents: first studies

Enhanced Wastewater Treatment by Immobilized Enzymes

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