Enzyme‐Triggered Disassembly of Perylene Monoimide‐based Nanoclusters for Activatable and Deep Photodynamic Therapy

Cai, Yanfei; Ni, Dongqi; Cheng, Wenyu; Ji, Chendong; Wang, Yaling; Müllen, Kläus; Su, Zhiqiang; Liu, Ying; Chen, Chunying; Yin, Meizhen

doi:10.1002/anie.202001107

Cited by 103 publications

(78 citation statements)

References 51 publications

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“…Compared with the control groups, the tumor growths in FBC-80+L and FBC-200+L groups were observed to be significantly suppressed after 15 days. In addition, FBC-80+L group has better tumor suppression than FBC-200+L group, indicating that FBC nanogels with small particle size have a better photodynamic effect 50 . In order to further confirm the photodynamic therapeutic effect, the mice were sacrificed on the 15 th day.…”

Section: Resultsmentioning

confidence: 92%

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

2021

Chem. Sci.

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Section: Resultsmentioning

confidence: 92%

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

2021

Chem. Sci.

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“…Furthermore, during enzyme-triggered disassembly of FHP, the fluorescence intensity of this nanostructure can be largely enhanced with the elevation of ROS production, enabling the selfenhanced in situ NIR optical imaging as well as enhanced PDT. As a result, FHP exhibit remarkable tumor suppression ability in vivo with satisfied biosafety through precise imaging-guided, enzyme-triggered PDT with deep penetration (Cai Y. et al, 2020).…”

Section: Photodynamic Nanoprobes For Tumor Theranosticsmentioning

confidence: 99%

Activable Multi-Modal Nanoprobes for Imaging Diagnosis and Therapy of Tumors

et al. 2021

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Malignant tumors have become one of the major causes of human death, but there remains a lack of effective methods for tiny tumor diagnosis, metastasis warning, clinical efficacy prediction, and effective treatment. In this context, localizing tiny tumors via imaging and non-invasively extracting molecular information related to tumor proliferation, invasion, metastasis, and drug resistance from the tumor microenvironment have become the most fundamental tasks faced by cancer researchers. Tumor-associated microenvironmental physiological parameters, such as hypoxia, acidic extracellular pH, protease, reducing conditions, and so forth, have much to do with prognostic indicators for cancer progression, and impact therapeutic administrations. By combining with various novel nanoparticle-based activatable probes, molecular imaging technologies can provide a feasible approach to visualize tumor-associated microenvironment parameters noninvasively and realize accurate treatment of tumors. This review focuses on the recent achievements in the design of “smart” nanomedicine responding to the tumor microenvironment-related features and highlights state-of- the-art technology in tumor imaging diagnosis and therapy.

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“…[26] Recently, Cai et al synthesized carboxylesterase (CE)-responsive tetrachloroperylene monoimide (P1) that could be assembled with folate-modified HSA into a nanocluster (FHP) possessing a diameter of ≈100 nm. [27] The CE within the tumor could hydrolyze P1 in the FHP, thus causing the FHP to disassemble into ultrasmall particles possessing a size of ≈10 nm. Additionally, HSA-coated NSs have been reported to exhibit stimulus-responsive size changeability.…”

Section: 4 Dissociable Aggregates Formed By Small Nssmentioning

confidence: 99%

Size‐Transformable Nanostructures: From Design to Biomedical Applications

et al. 2020

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AuNPs) with a size of 50 nm were more easily internalized into mammalian cells than were AuNPs of other sizes (14, 30, 74, and 100 nm). [3] Jiang et al. demonstrated that gold and silver nanoparticlemediated cellular responses were size dependent. [4] Wang et al. reported that the size of micelles significantly influenced their blood circulation time, tumor accumulation, and tumor penetration. [5] Additionally, nanoparticles exhibited sizedependent antibacterial activity and biofilm penetration properties. [6] Typically, small NSs possess the advantages of: 1) high surface-to-volume ratio that provides them with a large surface by which to contact the biological environment, [6b] 2) excellent biosafety and biocompatibility owing to their ease of excretion from living systems, [7] 3) capability to cross intracellular or in vivo barriers such as cell nuclear membranes [8] and blood-brain barriers (BBBs) [9] that allows them to enter these difficult-to-reach regions, and 4) strong penetration ability to reach the depths of solid tumors [10] and bacterial biofilms. [11] In comparison, large NSs typically exhibit long tissue retention periods [12] and slow exocytosis rates from the cells, [13] both of which are ideal for long-term imaging and effective treatment. Moreover, certain large NSs possess more favorable properties than do small ones in regard to enhanced theranostics. [14] To achieve satisfactory theranostic performance in addition to acceptable biosafety, NSs should exhibit the merits of both small and large NSs, and these merits include long-term retention, deep penetration, and rapid clearance. Among the various strategies used for overcoming the size paradox, utilizing size-transformable NSs has been demonstrated to be an available and effective method, as these types of NSs can easily integrate the advantages of small and large NSs. They can behave as small NSs for tissue penetration, rapid clearance, and crossing biological barriers, and can act as large NSs to meet the demands of long-term retention at the targeted sites. During or after the size transformation in these NSs, the loaded drugs within the NSs can be exposed or released from the system, ultimately enabling the transformable NSs to provide a versatile platform for disease theranostics. Based on their superior properties, a great deal of progress in regard to the design and applications of size-transformable NSs has occurred over the last several decades. [15] In this review, we focus on summarizing the design methods and biomedical applications of two types of size-transformable NSs, specifically the size-decreasing and size-increasing NSs. In addition to the The size of nanostructures (NSs) strongly affects their chemical and physical properties and further impacts their actions in biological systems. Both small and large NSs possess respective advantages for disease theranostics, and this therefore presents a paradox when choosing NSs with suitable sizes. To overcome this challenge, size-transformable NSs have emerged as a powerful tool,...

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Enzyme‐Triggered Disassembly of Perylene Monoimide‐based Nanoclusters for Activatable and Deep Photodynamic Therapy

Cited by 103 publications

References 51 publications

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

Activable Multi-Modal Nanoprobes for Imaging Diagnosis and Therapy of Tumors

Size‐Transformable Nanostructures: From Design to Biomedical Applications

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