Enzyme stabilization by glass-derived silicates in glass-exposed aqueous solutions

Ives, John A.; Moffett, John R.; Arun, Peethambaran; Lam, David; Todorov, Todor I.; Anick, David J.; Centeno, José A.; Namboodiri, M. A. A.; Jonas, Wayne B.

doi:10.1016/j.homp.2009.11.006

Cited by 46 publications

(84 citation statements)

References 35 publications

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“…The fact that many homeopathic remedies begin as source materials milled/ground in lactose for hours makes initial generation of top-down nanoparticles obligatory 98 . The documented ability of (1) succussions to release silica and nanosilica from the inside walls of glassware 85 and (2) plant mother tinctures to biosynthesize nanoparticles from silica 55 or metal precursors 9 , 233 in solution offer additional routes for making other types of nanoparticles in liquid remedies. Succussions, like sonication, 84 could also disperse larger nanoparticles into smaller particles.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, higher potencies would likely contain both remedy source nanoparticles and various nano-silica/nanosilicon structures from repeated rounds of multiple succussions in ethanolic solutions within glass containers 69 , 85 , 86 . As noted elsewhere, evidence shows that nanosilica and other nanoparticle carriers can enhance effects of traditional treatments for cancers such as snake venoms 103 - 105 , 120 , 162 .…”

Section: The Banerji Protocols: Using Homeopathic Remedies To Treat Cmentioning

confidence: 98%

“…Furthermore, the succussion process generates readily measurable amounts of silicon, silica (silicon dioxide), and its precursors from the glass walls of the container 64 , 69 , 85 , 86 . Studies on different glassware containing succussed homeopathic remedies, agitated non-homeopathic liquid solutions, and succussed control solutions all demonstrate the variable release of biologically active silica and related chemicals into solution 69 , 85 , 87 .…”

Section: Homeopathic Remedies As Nanomedicinesmentioning

confidence: 99%

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Integrative Nanomedicine: treating Cancer with Nanoscale Natural Products

Bell

Sarter

Koithan

et al. 2014

Glob Adv Health Med

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Finding safer and more effective treatments for specific cancers remains a significant challenge for integrative clinicians and researchers worldwide. One emerging strategy is the use of nanostructured forms of drugs, vaccines, traditional animal venoms, herbs, and nutraceutical agents in cancer treatment. The recent discovery of nanoparticles in traditional homeopathic medicines adds another point of convergence between modern nanomedicine and alternative interventional strategies. A way in which homeopathic remedies could initiate anticancer effects includes cell-to-cell signaling actions of both exogenous and endogenous (exosome) nanoparticles. The result can be a cascade of modulatory biological events with antiproliferative and pro-apoptotic effects. The Banerji Protocols reflect a multigenerational clinical system developed by homeopathic physicians in India who have treated thousands of patients with cancer. A number of homeopathic remedy sources from the Banerji Protocols (eg, Calcarea phosphorica; Carcinosin—tumor-derived breast cancer tissue prepared homeopathically) overlap those already under study in nonhomeopathic nanoparticle and nanovesicle tumor exosome cancer vaccine research. Past research on antineoplastic effects of nano forms of botanical extracts such as Phytolacca, Gelsemium, Hydrastis, Thuja, and Ruta as well as on homeopathic remedy potencies made from the same types of source materials suggests other important overlaps. The replicated finding of silica, silicon, and nano-silica release from agitation of liquids in glassware adds a proven nonspecific activator and amplifier of immunological effects. Taken together, the nanoparticulate research data and the Banerji Protocols for homeopathic remedies in cancer suggest a way forward for generating advances in cancer treatment with natural product–derived nanomedicines.

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Section: Resultsmentioning

confidence: 99%

Section: The Banerji Protocols: Using Homeopathic Remedies To Treat Cmentioning

confidence: 98%

Section: Homeopathic Remedies As Nanomedicinesmentioning

confidence: 99%

See 1 more Smart Citation

Integrative Nanomedicine: treating Cancer with Nanoscale Natural Products

Bell

Sarter

Koithan

et al. 2014

Glob Adv Health Med

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“…Multiple laboratories have demonstrated release of nanosilica and silicon from the inside walls of glassware from agitation of liquid solutions [6][7][8][9][27][28][29]. Mechanical agitation also disperses larger structures into small nanoparticles [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

“…Convergent basic science studies reveal the presence of mechanically-generated source material [3][4][5] and silica/silicon nanoparticles (NPs) in homeopathically-prepared medicines [4,[6][7][8][9]. Nanobubbles made during the manufacturing process may also contribute to the final product [8,10,11], which retains physicochemical properties of the original source material [12].…”

Section: Introductionmentioning

confidence: 99%

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Bell

Sarter

Koithan

et al. 2013

J Nanomed Nanotechol

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The purpose of the present paper is (a) to outline the self-organized, complex adaptive network nature of the organism as recipient of nanomedicines; (b) to propose several nonlinear endogenous amplification processes by which pulsed low doses of traditional, homeopathically-manufactured natural product nanomedicines may stimulate a return toward healthier function; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines. Homeopathy is an over 200-year-old system of complementary and alternative medicine (CAM) that uses low doses of natural plant-, mineral-, and animal-sourced nanomedicines. Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents. Agitation within glass containers at room temperature may also contribute nanosilica and nanosilicon as drug delivery vehicles and biological amplifiers. The medicine selection is matched to the recipient organism's systemic patterns of dysfunction and pulsed in the timing of the discrete doses. Endogenous amplification processes within the recipient organism may involve hormesis, time-dependent sensitization, and/or stochastic resonance. Effects are adaptive and systemically diffuse, i.e., causally indirect, rather than pharmacological and local, i.e., direct. All of these nonlinear response processes require interaction of the nanoparticle (NP) dose with the organism as a complex adaptive system. The pulsed NP dose serves as a low intensity salient danger signal for the organism to make network-wide adaptive changes that can lead to healing. The historically safe therapeutic approach of homeopathic nanomedicine dosing avoids risks of high, continuous doses and cumulative toxicity that contemporary nanomedicine researchers are now trying to solve while using NPs as if they were conventional bulk drugs. Integrating the insights, technical procedures, and clinical dosing approaches from modern and homeopathic nanomedicine could lead to major advances in the field for more effective and safer translational applications.NPs in homeopathic medicines [3]. NP concentrations are low, but measurable [3]. Like modern manufactured NPs [13], homeopathicallymanufactured medicines in solution also can exhibit aging effects [9,14]. These nanomedicines are delivered either in ethanolic liquids or sprayed and dried onto lactose or lactose/sucrose pellets for oral administration.Homeopathic manufacturing materials and methods are inherently "green" [15,16]. Previous papers have addressed the striking similarities between modern top-down mechanical attrition procedures for making nanoparticles (NPs) [17] and historical homeopathic medicine manufacturing methods and materials [15,[18][19][20][21]. These similarities include mechanically grinding source materials in lactose for hours and repeatedly agitating ethanol-water solutions containing the source Citation: Bell IR, Sarter B, Koithan M, Standish LJ, Banerji P, et al. (2013) Nonlinea...

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Less Is More: Finding the Right Dose

Davidson

2014

A Century of Homeopaths

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Enzyme stabilization by glass-derived silicates in glass-exposed aqueous solutions

Cited by 46 publications

References 35 publications

Integrative Nanomedicine: treating Cancer with Nanoscale Natural Products

Integrative Nanomedicine: treating Cancer with Nanoscale Natural Products

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Less Is More: Finding the Right Dose

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