Enzyme sensing based on a controllable oxidation reaction

Sheng, Ruilong; Ma, Jingjin; Wang, Pengfei; Liu, Weimin; Wu, Jiasheng; Li, Huaping; Zhuang, Xiaoqing; Zhang, Hongyan; Wu, Shikang

doi:10.1016/j.bios.2010.06.022

Cited by 14 publications

(17 citation statements)

References 34 publications

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“…Notably, the cell biological behaviors such as uptake, metabolism, and pharmacological applications of these steroid molecular tweezers are far from being understood. Moreover, the emergence of natural compound such as coumarin [23][24][25]-based fluorescent molecular receptors/sensors may inspire further development of steroid-based multichannel molecular receptors [4].…”

Section: Steroid-based Molecular Clefts/tweezersmentioning

confidence: 99%

Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation

Sheng¹

2020

Chemistry and Biological Activity of Steroids

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In this chapter, the biomedical application of steroid-based compounds at "beyond the molecule"-supramolecular level-is reviewed. The renewable and economic natural steroid compounds could be employed as building blocks in the design and construction of steroid-based supramolecular systems. The specific physicochemical features (size, shape, topology, hydrophobicity, chemical modifiability, etc.) and biological properties (biocompatibility, biodegradability, bioaffinity, etc.) could be integrated into functional supramolecular systems by chemical synthesis, modification and intermolecular interactions (such as hydrogen bonding, π-π stacking, van der Waals forces, inclusion interactions, chiral interactions, electrostatic interactions, and so on). The steroid-based (supra)molecules could be employed for molecular recognition and/or be self-assembled into various functional supramolecular assemblies for biomedical applications. The specific physicochemical and biological properties, good biocompatibility, and biological activity endow the steroid-based supramolecular systems good feasibility to be employed in biomolecular recognition/sensing and biomolecular transportation (gene/drug delivery). The examples in this chapter are exemplificative of the transformation of natural steroid-based compounds into functional steroid-based supramolecular systems through molecular and supramolecular engineering technology, moreover, which may inspire the systematic study of natural product-based supramolecular (nano)materials toward future pharmaceutical and biomedical industry.

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Section: Steroid-based Molecular Clefts/tweezersmentioning

confidence: 99%

Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation

Sheng¹

2020

Chemistry and Biological Activity of Steroids

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“…The conversion mechanism is similar to that reported in our previous work. 62 The effects of pH values on the sensing performance of our sensing system were investigated. The fluorescence intensity at 512 nm for material III with and without p-toluenethiol as a function of pH values was shown in Fig.…”

Section: Fluorescence Response Of Materials III Towards Thiophenolsmentioning

confidence: 99%

“…This phenomenon could be attributed to the catalysis effect of H + , which accelerates the oxidization reaction of 2H-coumarin 6 to coumarin 6. 62,63 On the other hand, the fluorescence enahncement also decreases at pH < 3 (e.g., pH 1.5), this may be because the 7-diethylamino group of coumarin derivatives is protonized at very acidic pH value, which decreases the fluorescence intensity of coumarin derivatives including coumarin 6. 64,65 Therefore, to improve the signal/noise ratio of the sensing system, a citric acid (0.1 M)-phosphate (0.2 M) buffer at pH 3 was chosen as the detection medium.…”

Section: Fluorescence Response Of Materials III Towards Thiophenolsmentioning

confidence: 99%

A novel fluorogenic hybrid material for selective sensing of thiophenols

Zhao

Liu

et al. 2011

J. Mater. Chem.

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“…Diethylaminocoumarin is a good fluorophore, , which possesses some good features including high fluorescence quantum yield and large Stokes shift . In this work, we utilized diethylaminocoumarin to construct a deep red fluorescence probe 1 , which would exhibit a ratiometric fluorescence response toward benzoyl peroxide along with a significant color alteration.…”

Section: Introductionmentioning

confidence: 99%

Rapid and Visual Detection of Benzoyl Peroxide in Food by a Colorimetric and Ratiometric Fluorescent Probe

Qin

et al. 2018

J. Agric. Food Chem.

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A coumarin-based fluorescent probe was prepared for rapid and visual detection of benzoyl peroxide. The probe could quantitatively determine benzoyl peroxide with fast response (<6 min), high sensitivity, and low limit of detection (163 nM). The probe exhibited good response toward benzoyl peroxide with a significant color change from blue to yellow along with fluorescence color alteration from red to blue. The probe determined benzoyl peroxide in real food samples (wheat flour, noodle, and dumpling flour) with good recoveries (90−114%). Furthermore, the probe was prepared into a paper-based test kit to determine benzoyl peroxide (30−100 μM) in real food samples with noticeable color and fluorescence change.

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Enzyme sensing based on a controllable oxidation reaction

Cited by 14 publications

References 34 publications

Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation

Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation

A novel fluorogenic hybrid material for selective sensing of thiophenols

Rapid and Visual Detection of Benzoyl Peroxide in Food by a Colorimetric and Ratiometric Fluorescent Probe

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