Enzyme-responsive multifunctional peptide coating of gold nanorods improves tumor targeting and photothermal therapy efficacy

Wu, Liming; Lin, Bingyi; Huang, Yang; Chen, Jing; Mao, Zhengwei; Wang, Weilin; Gao, Changyou

doi:10.1016/j.actbio.2019.01.026

Cited by 63 publications

(37 citation statements)

References 48 publications

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“…MMPs, or endopeptidases, can destroy the ECM proteins that are overexpressed in the extracellular niches of tumors, which play a key role in tumor growth and metastasis. 90 MMP-2 and MMP-9 are two of the most investigated MMPs. 91 In one work, the MMP-sensitive peptide GPLGVRGDG was included in a block copolymer.…”

Section: Recent Applications Of Ptx Nanomedicine For the Treatment Of...mentioning

confidence: 99%

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

et al. 2022

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Section: Recent Applications Of Ptx Nanomedicine For the Treatment Of...mentioning

confidence: 99%

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

et al. 2022

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“…Enzymes are crucial constituents of cells and play essential roles in intracellular activities and extracellular signaling pathways. Dysfunctional enzymes in the tumor microenvironment have been exploited as stimuli for drug delivery and tumor targeting [38][39][40]. Enzymatic stimuli are characterized by a high relevance for numerous diseases, specific substrate selectivity, and high catalytic efficiency.…”

Section: Enzymesmentioning

confidence: 99%

“…Gold nanoparticles were aggregated and retained in the tumor due to instability in the MMP-abundant environment, since the space resistance of PEG on the surface of gold nanoparticles were diminished along with the peptide cleaved by MMP. Similarly, the enzyme-cleavable zwitterionic stealth peptide that consisted of MMP-9 cleavable cell-penetrating Tat sequences was applied to coat gold nanorods for controllable tumor therapy [40]. The MMP-9 cleavable coating facilitated nanoparticles satisfactory systemic circulation lifetime and significantly enhanced cellular uptake in tumor.…”

Section: Enzymesmentioning

confidence: 99%

Smart Nanoparticles for Chemo-Based Combinational Therapy

et al. 2021

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Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated with low therapeutic index, acquired resistance, and various adverse effects. With the increasing understanding of cancer biology and technology advancements, more strategies have been exploited to optimize the therapeutic outcomes. The rapid development and application of nanomedicine have motivated this progress. Combinational regimen, for instance, has become an indispensable approach for effective cancer treatment, including the combination of chemotherapeutic agents, chemo-energy, chemo-gene, chemo-small molecules, and chemo-immunology. Additionally, smart nanoplatforms that respond to external stimuli (such as light, temperature, ultrasound, and magnetic field), and/or to internal stimuli (such as changes in pH, enzymes, hypoxia, and redox) have been extensively investigated to improve precision therapy. Smart nanoplatforms for combinational therapy have demonstrated the potential to be the next generation cancer treatment regimen. This review aims to highlight the recent advances in smart combinational therapy.

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“…It has been shown that adding a PPPP motif can increase the packing density of the selfassembled peptide monolayers and improve the antifouling properties of the surface grafted zwitterionic peptide. 40 Such advantages have been exploited for engineering various zwitterionic peptides for various applications, such as surface functionalization of implants 41 , biosensors 42,43 , drug delivery 44,45 , and antifouling applications. [46][47][48] Various parameters, including the peptides sequences, chain length, charge distribution, and solution ionic environment can affect the antifouling properties of the surface tethered zwitterionic peptide.…”

Section: Introductionmentioning

confidence: 99%

Structures and Antifouling Properties of Self-Assembled Zwitterionic Peptide Monolayers: Effects of Peptide Charge Distributions and Divalent Cations

Liu

et al. 2020

Biomacromolecules

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Zwitterionic peptides are great candidates as antifouling coating materials in many biomedical applications. We investigated the structure and antifouling properties of surface tethered zwitterionic peptide monolayers with different peptide chain lengths and charge distributions using a combination of surface plasma resonance (SPR), atomic force microscopy (AFM), and all atomistic molecular dynamics (MD) simulation techniques. Our results demonstrate that longer zwitterionic peptides exhibit better antifouling performance. The patchy charge distributions of the positive and negative charges in the peptides, although affecting the structure of the peptide molecules, do not significantly change the antifouling properties of the peptide monolayers in solution containing monovalent. However, divalent cations, Ca 2+ and Mg 2+ , in solution can significantly alter the structure and lower the antifouling performance of the zwitterionic peptide monolayers, especially with the sequences of patchy charge distributions. All atomistic MD simulations quantitatively reveal that the divalent cations in solution lead to more inter-chain electrostatic crosslinks between peptide chains, especially for peptides with patchy charges, which causes dehydration of the zwitterionic peptides and diminishes their antifouling performances.

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Enzyme-responsive multifunctional peptide coating of gold nanorods improves tumor targeting and photothermal therapy efficacy

Cited by 63 publications

References 48 publications

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Smart Nanoparticles for Chemo-Based Combinational Therapy

Structures and Antifouling Properties of Self-Assembled Zwitterionic Peptide Monolayers: Effects of Peptide Charge Distributions and Divalent Cations

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