Enzyme Regulation

Ding, Xunshan; Zhang, Q-Y.

doi:10.1016/b978-0-12-801238-3.95619-8

Cited by 1 publication

(1 citation statement)

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“…This also leads to altered enzymatic activity as a result of changes in amino acid sequences, which leads to changes in transcription, intrinsic termination, and factor-dependent termination. In some cases, SNP or mutations do not affect the activities of the enzymes, and it is important to identify those mutations that affect the activities of the specific gene (Ding and Zhang, 2010).…”

Section: Introductionmentioning

confidence: 99%

Biochemical association between the prevalence of genetic polymorphism and myocardial infarction

Shahid¹,

Rehman²,

Akash³

et al. 2023

Biocell

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Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction (MI).Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state. A single gene can exhibit genetic polymorphism at more than one position giving rise to different variants. Genetic polymorphism of angiotensinogen (AGT) M235T, AGT T174M, and angiotensin-1-converting enzyme (ACE) I/D, endothelial nitric oxide synthase (eNOS), and methylenetetrahydrofolate reductase (MTHFR) can be a risk factor for MI. However, it is important to study the prevalence of genetic polymorphisms of these genes among different populations. MI is influenced by genetic polymorphism of various genes, including AGT, ACE, eNOS, MTHFR, etc. However, the association of genetic polymorphism of these genes varies among different populations, but different ethnic groups could show contradictory results. These genes have shown a positive association with risks of MI in some populations, whereas the results have not been consistent with every ethnic group. In this article, we have summarized the genetic variations in the aforementioned genes and their association with MI.

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Section: Introductionmentioning

confidence: 99%