Enzyme-mediated fast in situ formation of hydrogels from dextran–tyramine conjugates

Enhanced tissue adhesiveness of injectable gelatin hydrogels through dual catalytic activity of horseradish peroxidase

“…The mixture was gently shaken at room temperature until no flow was observed. [21,22] We recorded the time at that point, defined as the gelation time. In addition, the gelation time of one sample (GH5/GS1) was checked again by using more quantitative method, a rheometer (Advanced Rheometer GEM-150-050, Bohlin Instruments, USA) was used to record the plotted curve of storage modulus (G 0 ) and loss modulus (G 00 ) as a function of time.…”

Enzyme Initiated Radical Polymerizations

“…However, even if no phenolic side chain is present in the polymer, it may be introduced chemically. In that respect, tyramine has gained some popularity e.g., for the crosslinking of carboxymethyl cellulose [154], alginate [155], hyaluronic acid [156], dextran [157] or artificial polymers such as Tetronic [158].…”

Introductory Chapter: Multi-Aspect Bibliographic Analysis of the Synergy of Technical, Biological and Medical Sciences Concerning Materials and Technologies Used for Medical and Dental Implantable Devices

“…Different synthetic and natural polymers were used for this purpose, including polyethylene glycol (PEG), and copolymers containing PEG [486,510], hyaluronic acid (HA) [511] after an oxidation reaction through HA-tyramine conjugates [505] and as a result of the formation between HA-SH [492,512] and Michael addition [491,513], collagen and gelatin hydrogels mostly cross-linked using glutaraldehyde, genipin or water-soluble carbodiimides [513][514][515], chitosan [516][517][518][519], dextran 192 [520,521] and alginate [522]. Hydrogels were used for reconstruction of the retina [523], ligament [524], fatty tissue [465], kidneys [525], muscles [526], blood vessels [527,528], and also heart, neural cells, invertebral discs, bones and gristle [459].…”