Enzyme-like Acyl Transfer Catalysis in a Bifunctional Organic Cage
Keith G. Andrews,
Tomasz K. Piskorz,
Peter N. Horton
et al.
Abstract:Amide-based organic cage cavities are, in principle, ideal enzyme active site mimics. Yet, cage-promoted organocatalysis has remained elusive, in large part due to synthetic accessibility of robust and functional scaffolds. Herein, we report the acyl transfer catalysis properties of robust, hexaamide cages in organic solvent. Cage structural variation reveals that esterification catalysis with an acyl anhydride acyl carrier occurs only in bifunctional cages featuring internal pyridine motifs and two crucial an… Show more
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