Enzyme inhibitors from the aril of Myristica fragrans

Sathya, S.; Amarasinghe, Nilupa R.; Jayasinghe, Lalith; Araya, Hiroshi; Fujimoto, Yukio

doi:10.1016/j.sajb.2019.12.020

Cited by 13 publications

(6 citation statements)

References 21 publications

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“…Phenolic compounds from natural sources have shown anticholinesterase activity in several studies [ 34 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]. Phenolic compounds whose anticholinesterase activities have been reported are given in the Supplementary Material ( Table S2 ).…”

Section: Discussionmentioning

confidence: 99%

“…The phenolic acid compounds 42 – 45 , and compound 44 ferulic acid methyl ester have a good percentage of cholinesterase inhibition [ 17 , 18 , 57 ]. The presence of sugar substituents causes a decrease in cholinesterase inhibition as seen in compounds 46 – 48 [ 17 , 58 ], while an additional phenolic group causes an increase in cholinesterase inhibition as seen in compounds 49 – 64 [ 16 , 18 , 47 , 52 , 59 , 60 , 61 , 62 ]. Amongst the biphenyl compounds, 58 , 59 , 60 , and 61 isolated from Myristica cinnamomea have high activity, and in these compounds, the carbonyl function is adjacent to one of the phenyl groups (phenyl carbonyl).…”

Section: Discussionmentioning

confidence: 99%

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Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

et al. 2021

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Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

et al. 2021

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“…In addition to the above phytochemical constituents, the presence of compounds Mal C and Mal B, which are present in most of the members of genus Myristica potentially proves its consideration in developing a chemo-taxonomical library for the identification of this genus. Mal C is one among the extensively explored chemical content predominantly present in genus Myristica, known for its possible therapeutic potential for treating cancer and inflammatory disorders [51,52], Alzheimer's disease [53], and infectious diseases [54]. The present study also highlights the…”

Section: High-resolution Liquid Chromatography Mass Spectrometry (Hr-lc-esi-ms/ms) Analysis Of Bioactive Extractmentioning

confidence: 55%

HR-LC-MS based profiling of phytochemicals from methanol extracts of leaves and bark of Myristica dactyloides Gaertn. from Western Ghats of Karnataka, India

Mallikarjunaiah¹,

Nuthan²,

Channarayapatna-Ramesh³

et al. 2021

J App Biol Biotech

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Untargeted profiling of phytochemicals from plant extracts would aid in the exploration of various groups of compounds and assist in the identification of new bioactive compounds, reducing the redundancy in compound identification. The potential bioactive phytochemicals present in Myristica dactyloides, an endemic ethnomedicinal plant widely used in traditional treatment practices, were explored and cataloged in this study. The untargeted phytochemical profile of active methanolic leaves and bark extracts was assessed by Ultra high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-offlight mass spectrometry. Preliminary screening results highlighted the high efficiency of methanolic extract as an effective antioxidant and anti-inflammatory agent, along with a remarkable amount of total phenolics and flavonoid content. Thus, the methanolic extracts of leaves and bark samples were further subjected to catalog its chemical constituents through untargeted metabolite profiling. Analysis of high-resolution liquid chromatography-mass spectrometer spectra, exhibited 3,813 and 1,797 molecular features in the ESI+ mode with clean retention time-exact mass, resulted in identifying 35 major therapeutically important common compounds for the first time in both leaves and bark extracts of M. dactyloides, fitting to major groups like lignans, neolignans, phenylpropanoids, diarylnonanoid, flavonoids, and others. Our results prove the presence of Myoinositol, Malabaricone B, Malabaricone C, Malabaricone D, and 1-(2,6-dihydroxyphenyl)-9-(4-hydroxy-3-methoxyphenyl) nonan-1-one previously reported from M. dactyloides, along with promising chemical signatures like Monotropein, Austrobailignan 7, Fragransol B, Guaiacin, Myricanone, Nectandrin A, Argenteane, and Epicatechin to the phytochemical catalog of M. dactyloides. Furthermore, our research not only confirms the existence of previously known molecules and adds new phytochemicals, but it also sheds light on the wide application of M. dactyloides for possible bio-prospecting for a new chemical entity.

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Section: Introductionmentioning

confidence: 99%

“…1 Myristica fragrans extract and its constituents have been reported to exert various biological activities, such as anti-inflammatory, antioxidant, antibacterial, antifungal, anti-obesity, antidiabetic and anticancer. [2][3][4][5][6][7] Hyperglycemia is one of the triggers for diabetes mellitus, which causes several complications such as cardiac disease, nerve damage and kidney disease. 8 The cause of hyperglycemia is insufficient insulin secretion from the pancreas and insulin resistance in peripheral tissues such as muscle, adipose tissue and liver.…”

Section: Introductionmentioning

confidence: 99%