Enzyme Induction by Enflurane in Man

Berman, M. L.; Green, Orville C.; Calverley, R. K.; Smith, Nicholas; Eger, Edmond I.

doi:10.1097/00000542-197606000-00007

Cited by 23 publications

(4 citation statements)

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“…A role of anaesthetic waste gases has been suggested (I), but there is no experimental evidence showing that trace concentrations of anaesthetic gases cause any micro-soma1 enzyme induction. Even exposure to anaesthetic concentrations of enflurane for many hours in man has caused only a weak inducing effect, indicated by increased urinary excretion of cortisol metabolites in five of six study subjects (13). The shortest vacation time of our anaesthetists was 2 weeks, which could have sufficed for metabolic enzyme recovery, however, since for example in rats phenobarbital-induced cytochrome P-450 activity returned to normal in 8 days (1 4).…”

Section: Discussionmentioning

confidence: 85%

Effects of Working Environment on the Liver in 10 Anaesthetists

Rosenberg¹,

Oikkonen²

1983

Acta Anaesthesiol Scand

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Drug-metabolising ability, i.e. antipyrine half-life, in anaesthetists was significantly slowed (23%) at the end of summer vacation (2-4 weeks), as compared to prevacation values. Despite changes in either direction, the antipyrine half-lives, including four determinations within a year and a half from the ten anaesthetists, were within normal limits. Liver enzymes (aspartate aminotransferase, alanine amino-transferase, alkaline phosphatase) were also normal. In one anaesthetist the test for anti-HBsAg was positive in 1980, while in the others HBsAg and anti-HBsAg were negative in 1980 and 1981. The inorganic fluoride concentrations of serum and urine (determined four times) were at normal levels. Only in one anaesthetist was there a transient, surprisingly high, serum concentration (7.9 mumol/l), apparently unrelated to work exposure.

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Section: Discussionmentioning

confidence: 85%

Effects of Working Environment on the Liver in 10 Anaesthetists

Rosenberg¹,

Oikkonen²

1983

Acta Anaesthesiol Scand

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“…The test is based on the observation that drugs inducing hepatic microsomal drug metabolizing enzymes also induce hydroxylation of steroid hormones [4][5][6]. The main advantage of measuring 6β-HC over some other tests is that it represents the biotransformation of a substrate of endogenous origin [7].…”

Section: Introductionmentioning

confidence: 99%

“…The main advantage of measuring 6β-HC over some other tests is that it represents the biotransformation of a substrate of endogenous origin [7]. The increased excretion of 6β-HC is an indication of induction of hepatic microsomal hydroxylase and an indirect index of enzyme induction by drugs in man, and the urinary level of 6β-HC is directly correlated with C3A4 and hepatic microsomal 6β-hydroxylase content [2,4,[7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Urinary Profile of 6β-Hydroxycortisol in Workers Exposed to Aluminum

Baydar

Aydın

Şahin

2007

Biol Trace Elem Res

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The aim of the present study was to evaluate whether aluminum exposure may cause alterations of cytochrome P4503A4 by measuring the urinary excretion of 6 beta-hydroxycortisol as biomarker. There is a positive correlation between urinary 6 beta-hydroxycortisol and aluminum excretion (p < 0.05). The correlations between occupational duration, smoking habits, and age were also evaluated. The increased excretion of the biomarker suggests that this element may induce formation of cytochrome P 450 in exposed individuals.

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“…In man, the evidence for enzyme induction caused by anaesthetic agents IS more circumspect. Berman et al (1976) suggested th::lt an increase in the ratio of 6-(3-hydroxycortisol to 17 hydroxycorticosteroids in the urine of patients after enflurane-induced anaesthesia was evidence of enzyme induction.…”

Section: Introductionmentioning

confidence: 99%

Altered Drug Metabolism in Anaesthetists Exposed to Volatile Anaesthetic Agents

Frewin

et al. 1978

Anaesth Intensive Care

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Antipyrine kinetics were measured on saliva in eight anaesthetists during a period when they were giving general anaesthetics and a period when they were working exclusively in intensive care. During the anaesthesia period there was a reduction in antipyrine half-life and the clearance of antipyrine increased. A nalysis of the data in groups failed to detect these changes because of the wide variation in metabolism between subjects. Exposure to anaesthetic agents under non-scavenging operating theatre conditions appears to enhance hepatic metabolism.

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Enzyme Induction by Enflurane in Man

Cited by 23 publications

References 0 publications

Effects of Working Environment on the Liver in 10 Anaesthetists

Effects of Working Environment on the Liver in 10 Anaesthetists

Urinary Profile of 6β-Hydroxycortisol in Workers Exposed to Aluminum

Altered Drug Metabolism in Anaesthetists Exposed to Volatile Anaesthetic Agents

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