“…In addition to molecular monolayers the enhancing surface can also be functionalized with thin layers of molecularly imprinted polymers (MIPs) to facilitate target capture within complex sample matrices. 132,176,177 MIPs are often described as the synthetic analogues to antibody-antigen systems, since they function through a similar "lock and key" mechanism to selectively capture the template molecule used during MIP production, as illustrated in Figure 12A. 178 For example, Liu, Yang, et al designed a MIP-based magnetic SERS substrate for highly selective quantitative SERS analysis of paclobutrazol pesticide residues in complex environments.…”
Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique, which allows quantitative detection of chemical species with molecular specificity and single-molecule sensitivity. These useful properties can be further combined with...
“…In addition to molecular monolayers the enhancing surface can also be functionalized with thin layers of molecularly imprinted polymers (MIPs) to facilitate target capture within complex sample matrices. 132,176,177 MIPs are often described as the synthetic analogues to antibody-antigen systems, since they function through a similar "lock and key" mechanism to selectively capture the template molecule used during MIP production, as illustrated in Figure 12A. 178 For example, Liu, Yang, et al designed a MIP-based magnetic SERS substrate for highly selective quantitative SERS analysis of paclobutrazol pesticide residues in complex environments.…”
Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique, which allows quantitative detection of chemical species with molecular specificity and single-molecule sensitivity. These useful properties can be further combined with...
“…The method leads to a high sensitivity with a LOD of 0.5 ng ml −1 and recoveries of 99–115%, demonstrating that atrazine and other herbicides and pesticides can be detected using this immunoassay. With the help of heteroatom-doped grapheme, Zhu et al fabricated a colorimetric nanozyme sensor arrays for detection of the aromatic pesticides via the TMB/H 2 O 2 system ( Zhu et al, 2020a ). Five different pesticides like fluroxypyr-meptyl, lactofen, diafenthiuron, bensulfuron-methyl, and fomesafen were successfully detected from 5 to 500 μM.…”
Section: Application In Food Contaminants Detectionmentioning
Nanozymes own striking merits, including high enzyme-mimicking activity, good stability, and low cost. Due to the powerful and distinguished functions, nanozymes exhibit widespread applications in the field of biosensing and immunoassay, attracting researchers in various fields to design and engineer nanozymes. Recently, nanozymes have been innovatively used to bridge nanotechnology with analytical techniques to achieve the high sensitivity, specificity, and reproducibility. However, the applications of nanozymes in food applications are seldom reviewed. In this review, we summarize several typical nanozymes and provide a comprehensive description of the history, principles, designs, and applications of nanozyme-based analytical techniques in food contaminants detection. Based on engineering and modification of nanozymes, the food contaminants are classified and then discussed in detail via discriminating the roles of nanozymes in various analytical methods, including fluorescence, colorimetric and electrochemical assay, surface-enhanced Raman scattering, magnetic relaxing sensing, and electrochemiluminescence. Further, representative examples of nanozymes-based methods are highlighted for contaminants analysis and inhibition. Finally, the current challenges and prospects of nanozymes are discussed.
“…Chen et al, 2018;Foti et al, 2018;Guselnikova et al, 2019;Kang et al, 2019;Shao et al, 2018;Song et al, 2018;Y. Wu et al, 2018;Yang et al, 2017;Zhu et al, 2020)…”
Section: Introductionunclassified
“…Schematic illustration of mycotoxins detection based on SERS. Some of the images are reprinted with permission from various studies (Q. Chen et al., 2018; Foti et al., 2018; Guselnikova et al., 2019; Kang et al., 2019; J. Li et al., 2019; Shao et al., 2018; Song et al., 2018; X. Wang et al., 2018; Y. Wu et al., 2018; Yang et al., 2017; Zhu et al., 2020)…”
Mycotoxins are toxic compounds naturally produced by certain types of fungi. The contamination of mycotoxins can occur on numerous foodstuffs, including cereals, nuts, fruits, and spices, and pose a major threat to humans and animals by causing acute and chronic toxic effects. In this regard, reliable techniques for accurate and sensitive detection of mycotoxins in agricultural products and food samples are urgently needed. As an advanced analytical tool, surface‐enhanced Raman spectroscopy (SERS), presents several major advantages, such as ultrahigh sensitivity, rapid detection, fingerprint‐type information, and miniaturized equipment. Benefiting from these merits, rapid growth has been observed under the topic of SERS‐based mycotoxin detection. This review provides a comprehensive overview of the recent achievements in this area. The progress of SERS‐based label‐free detection, aptasensor, and immunosensor, as well as SERS combined with other techniques, has been summarized, and in‐depth discussion of the remaining challenges has been provided, in order to inspire future development of translating the techniques invented in scientific laboratories into easy‐to‐operate analytic platforms for rapid detection of mycotoxins.
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