Enzyme Histochemical Investigations of Candida albicans After Treatment with Rilopirox, a Novel Fungicidal Hydroxy-Pyridone

Reitze, H. K.; Seitz, Karl‐August; Dannhorn, D. R.; Hänel, H.; Bohn, Manfred

doi:10.1007/978-3-642-58401-5_2

Hydroxy-Pyridones as Antifungal Agents With Special Emphasis on Onychomycosis 1999

DOI: 10.1007/978-3-642-58401-5_2

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Enzyme Histochemical Investigations of Candida albicans After Treatment with Rilopirox, a Novel Fungicidal Hydroxy-Pyridone

H. K. Reitze¹,

Karl‐August Seitz²,

D. R. Dannhorn³

et al.

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2006

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Cited by 2 publications

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In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains

Roques¹,

Brousse²,

Panizzutti³

2006

Mycopathologia

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The aim of this study was to determine the in vitro fungicidal and growth inhibitory activity of ciclopirox olamine alone (1% and 1.5%) or in association with 1% zinc pyrithione compared to 2% ketoconazole, against Malassezia species particularly involved in the pathogenesis of seborrheic dermatitis. Experiments were performed on Malassezia globosa IP 2387.96 and M. restricta IP 2392.96 strains. Growth inhibitory activity of the active compounds in solution was evaluated by measuring minimal inhibitory concentrations using a broth micro-method and their fungicidal activity by a filtration method after contact times between solutions and yeasts ranging from 3-5 to 30 min. Concerning the determination of minimal inhibitory concentration of ciclopirox olamine/zinc pyrithione, it revealed the marked synergistic inhibitory effect of the association, leading to a higher efficacy compared to ketoconazole. As to the fungicidal activity of ciclopirox olamine, it significantly increased with the contact time. After 15-30 min of contact between 1.5% ciclopirox olamine and Malassezia strains, a 2-log reduction of Malassezia counts was observed. The 1.5% ciclopirox olamine/1% zinc pyrithione association was characterized by a steady fungicidal efficacy whereas the 2% ketoconazole solution did not express any fungicidal effect. In conclusion, this study demonstrates the in vitro inhibitory and fungicidal efficacy of the ciclopirox olamine/zinc pyrithione association against Malassezia species and underscores its potential interest in the treatment of seborrheic dermatitis.

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In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains

Roques¹,

Brousse²,

Panizzutti³

2006

Mycopathologia

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Einsatz und Bedeutung von Ciclopirox‐Lack

Tietz¹,

Ulbricht²

2002

H G Z Hautkrankh

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Zusammenfassung: Onychomykosen sind weltweit verbreitet. Epidemiologische Untersuchungen beziffern den Anteil von Nagelpilzerkrankungen unter den Oberfla È chenmykosen mit bis zu 30 %. Onychomykosen werden von Patienten als sto È rend und einschra È nkend in bezug auf Alltag und Sozialkontakte angesehen. Seit Beginn der neunziger Jahre wurden moderne Behandlungsmethoden entwickelt. Neben oralen Antimykotika spielen die antimykotischen Lacke wie Ciclopirox-Lack, der in 45 La È ndern der Erde eingesetzt wird, eine groûe Rolle. Der Lack ist zur Behandlung aller Formen der Onychomykose zugelassen und wirkt fungizid und sporozid. Die Wirksamkeit als Monotherapeutikum, die sich auf alle potentiellen Auslo È ser einer Onychomykose erstreckt, wurde in zahlreichen Studien mit unterschiedlichem Patientenklientel belegt. Durch den substanzspezifischen Wirkmechanismus von Ciclopirox als Nicht-Ergosterolsynthesehemmer ergeben sich in Kombination mit oralen Antimykotika synergistische Effekte. Die Applikation auf die Na È gel erfolgt mit Hilfe eines Pinsels, was den Lack fu È r Patienten zu einem einfach anwendbaren Therapeutikum macht. Die seit der Markteinfu È hrung selten berichteten, lokal begrenzten Begleiterscheinungen lassen den Ciclopirox-Lack als nebenwirkungsarm gelten.

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Enzyme Histochemical Investigations of Candida albicans After Treatment with Rilopirox, a Novel Fungicidal Hydroxy-Pyridone

Cited by 2 publications

References 9 publications

In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains

In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains

Einsatz und Bedeutung von Ciclopirox‐Lack

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