2020
DOI: 10.1016/j.bpj.2019.11.2926
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Enzyme Function Prediction using Deep Learning

Abstract: The enzyme Protein Tyrosine Phosphatase 1B (PTP1B) is widely studied due to its role in a number of important cellular signaling pathways, including those related to type 2 diabetes and certain forms of cancer. Although wild type PTP1B has 435 residues, to date, most studies of PTP1B have focused on the catalytic domain, residues 1-301 or 1-321. In this study, we present a method for purifying a construct containing residues 1-393, which includes much of the previously excluded disordered C-terminus. We also p… Show more

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