Enzyme-free sandwich-type electrochemical immunosensor for CEA detection based on the cooperation of an Ag/g-C3N4-modified electrode and Au@SiO2/Cu2O with core-shell structure

Liao, Xiaochen; Xiao, Wang; Ma, Chaoyun; Zhang, Li; Zhao, Chulei; Chen, Siyu; Li, Keqiang; Zhang, Mengmeng; Mei, Lisha; Qi, Yu; Hong, Chenglin

doi:10.1016/j.bioelechem.2021.107931

Cited by 23 publications

(9 citation statements)

References 48 publications

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“…As a substitute for biozyme, some artificial nanozymes have been widely applied to the designing of multiplexed electrochemical immunosensing interfaces due to their considerable environmental tolerance, easy storage, and ideal catalytic activity [ 83 , 84 , 85 ]. Except for the aforementioned ways in which electrochemical signals are generated by the redox of electroactive species, nanozymes with peroxidase-like activity can also catalyze the H 2 O 2 to generate current variation with an i-t measurement [ 86 , 87 ]. Employing the platinum nanoparticle-functionalized mesoporous silica (Pt@SBA-15) to form an immunosensor array has been successfully used for the simultaneous determination of different analytes.…”

Section: Electrochemical Signal Substances For Multiplexed Immunoassaymentioning

confidence: 99%

Electrochemical Signal Substance for Multiplexed Immunosensing Interface Construction: A Mini Review

Feng¹,

Chu²,

Ma³

2022

Molecules

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Appropriate labeling method of signal substance is necessary for the construction of multiplexed electrochemical immunosensing interface to enhance the specificity for the diagnosis of cancer. So far, various electrochemical substances, including organic molecules, metal ions, metal nanoparticles, Prussian blue, and other methods for an electrochemical signal generation have been successfully applied in multiplexed biosensor designing. However, few works have been reported on the summary of electrochemical signal substance applied in constructing multiplexed immunosensing interface. Herein, according to the classification of labeled electrochemical signal substance, this review has summarized the recent state-of-art development for the designing of electrochemical immunosensing interface for simultaneous detection of multiple tumor markers. After that, the conclusion and prospects for future applications of electrochemical signal substances in multiplexed immunosensors are also discussed. The current review can provide a comprehensive summary of signal substance selection for workers researched in electrochemical sensors, and further, make contributions for the designing of multiplexed electrochemical immunosensing interface with well signal.

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Section: Electrochemical Signal Substances For Multiplexed Immunoassaymentioning

confidence: 99%

Electrochemical Signal Substance for Multiplexed Immunosensing Interface Construction: A Mini Review

Feng¹,

Chu²,

Ma³

2022

Molecules

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“… 94 Carcinoembryonic antigen (CEA) is an important biomarker for various cancers and antibodies against CD66 can recognize CEA family antigens according to the latest research. 47 , 85 , 94 Therefore, the detection of CEA may be useful for the diagnosis of leukemia. Liao et al 47 proposed an enzyme-free sandwich-structure electrochemical immunosensor based on 2D g-C 3 N 4 nanosheets for detecting CEA.…”

Section: Applications Of Electrochemical Biosensors In Leukemiamentioning

confidence: 99%

“… 47 , 85 , 94 Therefore, the detection of CEA may be useful for the diagnosis of leukemia. Liao et al 47 proposed an enzyme-free sandwich-structure electrochemical immunosensor based on 2D g-C 3 N 4 nanosheets for detecting CEA. Defect-rich structures made 2D g-C 3 N 4 a good electron donor and the loading of Ag nanoparticles (AgNPs) not only achieved more effective antibody 1 (Ab 1 ) loading but also further enhanced the conductivity of the sensor.…”

Section: Applications Of Electrochemical Biosensors In Leukemiamentioning

confidence: 99%

“… 33 , 42 , 46 g-C 3 N 4 is a novel nitrogen-doped carbon-based material with a large specific surface area and good biocompatibility. The rich defect structure of g-C 3 N 4 makes it a good electron donor and the doping of N further increases the electron transport rate in the electrocatalytic process, 47 which is important in electrochemical sensors, biosensors, and catalysis. 48 MOFs are crystalline coordination polymers with regular porous structures and abundant unique functional groups.…”

Section: Introductionmentioning

confidence: 99%

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Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

Sun

Huang

Wang

et al. 2022

Technol Cancer Res Treat

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Hematological malignancies encompass a wide variety of severe diseases that pose a serious threat to human health. Given the fact that hematological malignancies are difficult to treat due to their unpredictable and rapid deterioration and high rates of recurrence, growing attention has been paid to their early screening and diagnosis. However, developing a rapid and effective diagnostic tool featuring a noninvasive sampling technique is still extremely challenging. In recent years, novel nanomaterials-based electrochemical biosensors have attracted great interest because of such advantages as simple operation, low cost, fast response, etc. As a kind of rising nanomaterials, two-dimensional materials have excellent electronic and chemical properties, which have been proven to improve the performance of electrochemical biosensors. This review summarizes the applications of different types of electrochemical biosensors (nucleic acid sensors, immunosensors, aptamer biosensors, and cytosensors) based on two-dimensional materials in the detection of biological molecules related to hematological malignancies. Two-dimensional materials-based electrochemical biosensors designed for the diagnosis of leukemia could rapidly detect the target biomolecules at a trace level and show great merits such as wide linear range, low detection limit, high sensitivity, excellent selectivity, and cost-effectiveness. In addition, these biosensors have also achieved satisfactory results in the diagnosis of lymphoma and multiple myeloma. Thus, two-dimensional materials-based electrochemical biosensors are attractive for the early diagnosis of hematological malignancies in clinical practice. Nevertheless, more efforts are still required to further improve the performance of electrochemical biosensors. In this review, we propose the possible main concerns in the design of future two-dimensional materials-based electrochemical biosensors, involving the development of sensors for synchronous detection of diverse target biomolecules, the exploration of other superior two-dimensional materials, the simplification of the sensors fabrication process, the construction of new hybrid structures and how to avoid possible environmental issues.

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“…As is known, the loading of noble metal nanoparticles is still a research hotspot, especially in electrochemical immunosensors, because of their remarkable catalytic ability and splendid biocompatibility. 21,22 There are many methods for loading noble metals. However, the galvanic displacement method has mild preparation conditions, is convenient and quick, and is simpler than other methods that need reducing agents and organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Application of a CuS/Au heterostructure with peroxidase-like activity in immunosensors

Wang

Jiang

et al. 2022

New J. Chem.

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Enzyme-free sandwich-type electrochemical immunosensor for CEA detection based on the cooperation of an Ag/g-C3N4-modified electrode and Au@SiO2/Cu2O with core-shell structure

Cited by 23 publications

References 48 publications

Electrochemical Signal Substance for Multiplexed Immunosensing Interface Construction: A Mini Review

Electrochemical Signal Substance for Multiplexed Immunosensing Interface Construction: A Mini Review

Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

Application of a CuS/Au heterostructure with peroxidase-like activity in immunosensors

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