Enzyme‐free Electrochemical Detection of Hydrogen Peroxide Based on the Three‐Dimensional Flower‐like Cu‐based Metal Organic Frameworks and MXene Nanosheets^†

Abstract

Cu-based metal organic frameworks (MOFs) are regarded as promising sensing materials, which have abundant metal sites, large surface area and simple synthesis processes. In this work, a novel three-dimensional flower-like Cu-MOF was synthesized, which was combined with ultra-thin MXene nanosheets to construct a novel electrochemical sensor for H 2 O 2 . During the electrocatalytic reduction of H 2 O 2 , the catalytic activity of Cu-MOF/MXene/GCE results in the ultra-sensitive detection of H 2 O 2 owing to the structure properties of MOFs, the nature of Cu-contained nanomaterials as well as the high electrical conductivity of MXene. The Cu-MOF/MXene/GCE showed a wide linear range from 1 mol/L to 6.12 mmol/L using chronoamperometry at the detection potential of -0.35 V, and the detection limit is estimated to be 0.35 µmol/L. The sensor also shows good anti-interference due to the lower detection potential, specific catalysis of Cu-MOF to H 2 O 2 , which promises the sensor good selectivity in complexed samples. Meanwhile, the electrochemical sensor is capable to detect H 2 O 2 in milk and serum samples with satisfactory recoveries. The ultra-sensitivity, rapid detection, and easy operation of the proposed sensor present significant prospect for real-time analysis and monitoring of H 2 O 2 in foods and biological samples.

Metal–Organic Frameworks for Electrocatalytic Sensing of Hydrogen Peroxide

“…In addition, some researchers have improved electrocatalytic performance by combining MOFs with 2D materials such as graphene or black phosphorus nanosheets to form novel composites. Cheng et al [ 64 ] combined Mxene with MOFs to form a new 3D flower-like Cu-MOF/Mxene/GCE (glassy carbon electrode) material by taking advantage of Mxene’s high electrical conductivity and large specific surface area ( Figure 5 f). Owing to the large specific surface area of MXene, Cu-MOF was evenly dispersed on the surface, and the metal sites of MXene and Cu-MOF improved the catalytic ability of H 2 O 2 .…”

“…( d ) Particle size distributions of AgNPs in AgNPs@Y-1,4-NDC-MOF/ERGO and ( e ) CuNPs in CuNPs@Y-1,4-NDC-MOF/ERGO [ 62 ]; Copyright 2018, Elsevier. ( f ) The fabrication of the electrochemical sensor for the detection of H 2 O 2 [ 64 ]. Copyright 2021, Wiley.…”

Choline Oxidase-Integrated Copper Metal–Organic Frameworks as Cascade Nanozymes for One-Step Colorimetric Choline Detection

“…Since scientists discovered the first kind of inorganic nanometer material Fe 3 O 4 with catalytic activity, thorough research began to be carried out for other nanometer materials. − Some of them show similar catalytic activities to natural enzymes, and the catalytic reactions conform to the basic kinetic principles and mechanisms of enzymes, which are called nanozymes. Compared to natural enzymes, they exhibit similar catalytic activity, simple preparation, and stable properties, − thus show promising applications in many fields.…”

Synthesis and characterization of NiCo-X (X = OH, S, Se, P) nanodiscs and comparison of their electrocatalytic performances in an electrochemical sensing platform

“…In addition, due to the improvement of the surface-to-volume ratio, nanomaterials are also used as platforms in the design of biosensors. 1–4 The Earth-abundant transition metals ( e.g. cobalt and nickel) are relatively available, less costly, and less toxic than second and third-order transition metals (such as palladium, gold, silver, and platinum) and are more widely used in industry.…”