Enzyme Concentration and Absorption of Protein and Glucose in Duodenum of Premature Infants

Borgström, Bengt; Lindquist, Bertil; Lundh, G

doi:10.1001/archpedi.1960.02070030340010

Cited by 24 publications

(21 citation statements)

References 6 publications

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“…2 Before first feeding. 3 Age range: 9 months to 13 years. 1 Values are expressed on the basis of body weight (per kilogram) and represent means ± 1 so of the activities during 50 min after injections of pancreozymin and secretin.…”

Section: Resultsmentioning

confidence: 99%

“…2 Before first feeding. 3 Age range: 9 months to 13 years. that of subjects fed either low protein and high fat formula A or low fat and starch-containing formula B.…”

Section: Resultsmentioning

confidence: 99%

“…In this study we have overcome this difficulty by using a newly manufactured smaller tube which, as it is only 1 mm larger than a common nasogastric feeding tube, is easily introduced into newborn infants. Exocrine pancreas function in premature and full term neonates was first evaluated by Borgstrom et al [3] who, by using a test meal stimulation, demonstrated fairly good concentrations of trypsin and a-amylase per milliliter of duodenal contents. Their results, however, are not comparable with ours, which were obtained by using hormonal stimulations and which are expressed as total output per kilogram body weight.…”

Section: Methodsmentioning

confidence: 99%

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Exocrine Pancreas Function in Premature and Full Term Neonates

et al. 1972

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ExtractPancreatic response to pancreozymin and secretin stimulations has been studied in premature and full term neonates. The following results have been obtained. (7) At birth premature neonates have a fairly well developed exocrine pancreatic function which is, however, lower than that of full term neonates. (2) One week after birth, exocrine pancreatic activity becomes higher in premature than in full term neonates.(3) Early administration of small amounts of starch stimulates pancreatic a-amylase (EC. 3.3.1.1) production. (4) A high protein diet stimulates increased production of both trypsin (EC. 3.4.4.4) and lipase (EC. 3.1.1.3), whereas a high fat diet alone has no effect on lipase secretion. SpeculationExocrine pancreatic function is fairly well developed in premature neonates from 32-week gestation, although it is less developed at birth than it is in full term neonates and in older infants and children. After birth, the more rapid maturation of the exocrine pancreas function of premature neonates is probably related to the functional demands of a more rapid growth. The rates of maturation of secretion of a-amylase and trypsin increase proportionately to the starch and protein contents of the diet. The use of an appropriate diet therefore seems to be of great importance in regulating the secretions of the exocrine pancreas during the first month of life.

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Section: Resultsmentioning

confidence: 99%

“…2 Before first feeding. 3 Age range: 9 months to 13 years. that of subjects fed either low protein and high fat formula A or low fat and starch-containing formula B.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Exocrine Pancreas Function in Premature and Full Term Neonates

et al. 1972

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“…The preterm infant, compared with the term infant, is thought to be poorly equipped for the task of protein digestion (45,49). For example, a previous study showed that gastrointestinal trypsin activity is lower in preterm than term infants in early life (49).…”

Section: Figurementioning

confidence: 99%

Endogenous Human Milk Peptide Release Is Greater after Preterm Birth than Term Birth

Dallas

Smink

Robinson

et al. 2015

The Journal of Nutrition

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“…A previous study [9] from our labo ratory found active salivary amylase in the gastric aspirates of premature infants be tween 26 and 42 weeks of corrected gesta tional age. Borgstrom et al [28] have sug gested that much of the duodenal amylase in premature infants (1,600-2,200 g) is ac tually of salivary origin. Recently [10], it was shown that saliva from prematures pro duces significant glucose polymer hydrolysis in vitro.…”

Section: Discussionmentioning

confidence: 99%

Postprandial Glucose and Insulin Responses to Glucose Polymers by Premature Infants

Tucker¹,

Hodge²,

Choi³

et al. 1987

Neonatology

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Previous studies have questioned whether neonatal infants can digest and absorb glucose polymers (GP). Thirteen infants of 33–42 weeks of corrected gestational age were fed two glucose polymers with different dextrose equivalents (DE) and glucose. Postprandial glucose and insulin responses were measured consecutively after each feeding. At 60 min, glucose, glucose polymer DE 15 and glucose polymer DE 24 produced serum glucose responses of 138.1, 111.6 and 120 mg/100 ml, respectively. Differences in mean serum glucose and insulin levels were found when glucose or glucose polymers were used as the test carbohydrate. Glucose polymer DE 24 produced a hormonal response closer to that of glucose. This suggests that glucose polymers were hydrolyzed and absorbed and evoked a sufficient glucose and insulin response. Therefore, these glucose polymers would seem to be suitable for use in feeding neonatal infants.

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Enzyme Concentration and Absorption of Protein and Glucose in Duodenum of Premature Infants

Cited by 24 publications

References 6 publications

Exocrine Pancreas Function in Premature and Full Term Neonates

Exocrine Pancreas Function in Premature and Full Term Neonates

Endogenous Human Milk Peptide Release Is Greater after Preterm Birth than Term Birth

Postprandial Glucose and Insulin Responses to Glucose Polymers by Premature Infants

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