Enzyme-assisted high throughput sequencing of an expanded genetic alphabet at single base resolution
Bang Wang,
Kevin M. Bradley,
Myong-Jung Kim
et al.
Abstract:With just four building blocks, low sequence information density, few functional groups, poor control over folding, and difficulties in forming compact folds, natural DNA and RNA have been disappointing platforms from which to evolve receptors, ligands, and catalysts. Accordingly, synthetic biology has created “artificially expanded genetic information systems” (AEGIS) to add nucleotides, functionality, and information density. With the expected improvements seen in AegisBodies and AegisZymes, the task for syn… Show more
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