Enzyme Activity Alteration by Cadmium Administration to Rats: The Possibility of Iron Involvement in Lipid Peroxidation

Casalino, Elisabetta; Sblano, Cesare; Landriscina, C

doi:10.1006/abbi.1997.0197

Cited by 255 publications

(140 citation statements)

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“…Each bar represents the mean and SEM (n=4). Statistical significance of difference among groups at p<0.05; control versus 50 ppm cadmium treatment; 50 ppm cadmium treatment versus 50 ppm cadmium treatment along with herbal administration (both 45 and 65 days) and destruction of cell membranes [26,27]. SOD has proven a useful probe for studying the free radicals in reactions involving oxygen, since it acts as a defense against oxidative tissue damage by dismutation of superoxide radicals [28].…”

Section: Discussionmentioning

confidence: 99%

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Roopha¹,

Padmalatha²

2011

J. Med. Toxicol.

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Cadmium is one of the elements found to damage antioxidant systems in mammals. To ameliorate cadmium toxicity and to prevent oxidative stress, natural products may be useful. In Indian ethnobotanical practice, a mixture of 17 herbal products is used to fortify the reproductive system of women after parturition and to reverse ovarian oxidative stress. Oral administration of this extract to rats exposed to cadmium was useful in reversing oxidative stress. Two different doses of cadmium (50 ppm and 200 ppm) were given to Wistar rats aged 45 and 65 days. An herbal extract derived from 17 plants was administered orally every day at a dose level of 200 mg/kg of body weight to the rats exposed to cadmium. A battery of enzymes involved in antioxidant activity in the ovary, including superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione-s-transferase (GST) were measured in the control, cadmium-exposed rats without treatment and in the cadmium-exposed rats treated with herbal extract. The reduction in SOD, catalase, GPx and GST activity after cadmium exposure improved significantly in the rats treated with the herbal extract (p<0.05). The decrease of antioxidant enzymes due to cadmium exposure was reversed significantly with herbal extract administration. The synergistic effect of each bioactive compound in different herbal extracts requires further study.

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Section: Discussionmentioning

confidence: 99%

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Roopha¹,

Padmalatha²

2011

J. Med. Toxicol.

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“…It has also been suggested that higher gastrointestinal absorption of Cd is due to lower body Fe stores as measured by the concentrations of serum ferritins (Vahter et al, 1996). Petring et al, (1977) and Casalino et al, (1997) reported that Fe supplementation corrects the anemia caused by Cd exposure in rats. Therefore it is proposed that combination of trace elements in the sequence of Se + Cu and Zn + Fe are effective in reducing the Cd accumulation and thereby providing some therapeutic measures in Cd induced toxicity in rats.…”

Section: Resultsmentioning

confidence: 99%

Effect of combinations of four trace elements on cadmium bioaccumulation in a few tissues of male albino rats

Rani

Babu

Obaiah

2010

JANS

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Abstract:The present study is designed to investigate the accumulation of cadmium (Cd) in selected tissues such as liver, kidney, testis and small intestine of male albino rats treated for Cd and after combined supplementation with Zinc (Zn) + Iron (Fe) and Selenium (Se) + Copper (Cu). The wistar albino rats were treated with cadmium chloride(CdCl 2 )at a dose of 1/10 th LD 50 i.e. 22.5 mg / kg body weight for 7, 15 and 30 days(d) time intervals. After 15 d to Cd treatment, the rats were then supplemented with the above combination of two trace elements and then observed for accumulation of Cd at specific time intervals. These trace elements at a dosage of 1 mg/ kg body weight of Se, 16mg/kg body weight of Cu, 12 mg / kg body weight of Zn and 40 mg / kg body weight of Fe were given as supplements. There was significant Cd accumulation in liver and kidney among the selected tissues before to supplementation and there was significant decrease in the Cd accumulation levels in all the tissues after trace element supplementation. Moreover the 30d Zn + Fe supplemented rat kidney showed maximum decrease in Cd accumulation (8.327µg/g wet wt. of the tissue).

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“…The mechanism that explains the indirect role of cadmium in the formation of free radicals is that cadmium can replace iron and copper, and then it increases the amount of free iron and copper, which in turn will play a role in oxidative stress via the Fenton reaction [22], [23].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cadmium Absorption on Ghrelin and Malondialdehyde Levels in White Rats (Rattusnorvegicus)

Triawanti¹,

Sanyoto²,

Mashuri³

et al. 2014

IJBBB

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Abstract-Cadmium is expected to affect the absorption of other nutrients and appetite through the competition with the nutrients, causing damages to cell membranes through lipid peroxidation reactions. Damaged intestinal cells may disrupt the secretion of one of digestive hormones, ghrelin, theorexigenic hormone. The purpose of this study was to analyze the effect of cadmium exposure on the levels of ghrelin and malondialdehyde (MDA) in rats (Rattusnorvegicus). The study used post-test-only control group design, with 2 groups of white rats: control group (P0) was given placebo and treatment group (P1) was exposed to cadmium. Parameters measured were the levels of MDA and ghrelin. The results showed that there was no difference in body weights (p=0.057) and ghrelin concentrations (p=0.910) between the white rats in the control group and the treatment group. There were significant differences in the levels of MDA. The treatment group had a higher MDA level compared with control (p=0.001). It was concluded that the cadmium exposure for 4 group did not affect the secretion of ghrelin hormone and body weights of white rats, but might cause lipid peroxidation in white rats, as evidenced by the increased MDA level.

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Enzyme Activity Alteration by Cadmium Administration to Rats: The Possibility of Iron Involvement in Lipid Peroxidation

Cited by 255 publications

References 0 publications

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Effect of combinations of four trace elements on cadmium bioaccumulation in a few tissues of male albino rats

The Effect of Cadmium Absorption on Ghrelin and Malondialdehyde Levels in White Rats (Rattusnorvegicus)

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