Enzyme Activities in Erythrocytes of Term and Preterm Newborns

Belvisi, Elisa; Bracciali, Carlotta; Ognean, Mihai; Tei, Monica; Negro, Simona; Carrà, F.; Proietti, Fabrizio; Buonocore, Giuseppe; Perrone, Serafina

doi:10.1055/s-0036-1593814

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…They predispose preterm newborns to oxidative stress, through the free radical generation. Antioxidant capacity is lower in the newborn and particularly the premature infant in comparison to term newborn [2,16]. Therefore, premature infants are especially prone to oxidant injury, in various organs and systems [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Management of Oxygen Saturation Monitoring in Preterm Newborns in the NICU: The Italian Picture

Perrone

Giordano

Bernardo

et al. 2020

Preprint

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Background: Although many studies emphasize the importance of using oxygen saturation (SpO2) targets in the NICUs, there is a wide variability in used saturation ranges among centers. Primary aim was to draw a representative picture on how the management of oxygen monitoring is performed in the Italian NICUs. Second aim was to identify healthcare-professionals related factors associated with oxygen targeting in the preterm population. Methods: Cross-sectional study with data collection via an electronic survey form. A questionnaire containing pre-piloted and open questions on monitoring and management of the SpO2 was administered to neonatologists across the network of the Italian Society of Neonatology. The questions focused on: the infrastructure, specific training, healthcare professionals and patients-related factors. The results of the survey were anonymously collected, summarized and analyzed. Results: Out of 378 questionnaires, 93 were correctly filled. Thirty-six different SpO2 ranges were observed. Centers using written standard operating procedures on oxygen management and SpO2 monitoring maintained a correct average range of SpO2 90-95%, avoided hyperoxia and reconsidered saturation targets in relation to comorbidities. 39.8% of responders disabled alarms during neonatal care. One center used biomarkers for complete monitoring of neonatal oxygenation status. Conclusions: There is considerable variation in SpO2 targets for preterm infants in the Italian NICUs. Standard operating procedures and specific training for health care personnel are the main factors playing a role for the correct maintenance of the recommended oxygen targets in preterms.

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Section: Discussionmentioning

confidence: 99%

Management of Oxygen Saturation Monitoring in Preterm Newborns in the NICU: The Italian Picture

Perrone

Giordano

Bernardo

et al. 2020

Preprint

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“…Red blood cells (RBC) have a wide array of antioxidant enzymes defending against attacks by FRs. Superoxide dismutase (SOD), catalase (CT), and glutathione peroxidase (GPX) represent great antioxidant resources of these cells against stressors associated with prematurity [ 143 ]. Otherwise, after exposure of RBCs to OS, a rapid loss of activity of age-dependent enzymes from reticulocytes occurs probably due to proteolysis.…”

Section: Free Radical-related Diseases Of the Newborn: Overviewmentioning

confidence: 99%

The Free Radical Diseases of Prematurity: From Cellular Mechanisms to Bedside

Perrone

Santacroce

Longini

et al. 2018

Oxidative Medicine and Cellular Longevity

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During the perinatal period, free radicals (FRs) are involved in several physiological roles such as the cellular responses to noxia, the defense against infectious agents, the regulation of cellular signaling function, and the induction of a mitogenic response. However, the overproduction of FRs and the insufficiency of an antioxidant mechanism result in oxidative stress (OS) which represents a deleterious process and an important mediator of damage to the placenta and the developing fetus. After birth, OS can be magnified by other predisposing conditions such as hypoxia, hyperoxia, ischemia, hypoxia ischemia-reperfusion, inflammation, and high levels of nonprotein-bound iron. Newborns are particularly susceptible to OS and oxidative damage due to the increased generation of FRs and the lack of adequate antioxidant protection. This impairment of the oxidative balance has been thought to be the common factor of the so-called “free radical related diseases of prematurity,” including retinopathy of prematurity, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, kidney damage, and oxidative hemolysis. In this review, we provide an update focused on the factors influencing these diseases refining the knowledge about the role of OS in their pathogenesis and the current evidences of such relationship. Mechanisms governing FR formation and subsequent OS may represent targets for counteracting tissue damage.

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“…An imbalance between oxidants and antioxidants is called oxidative stress: a potential cause of cell damage [ 2 ]. Newborns, especially if preterm, are particularly susceptible to oxidative stress due to the immature antioxidant capacity and the likely exposure to many processes such as hypoxia, hypoxia-ischemia, hyperoxia and infections, leading to high levels of free radicals’ production [ 3 ]. Hypoxia and hyperoxia predispose preterm newborns to oxidative stress, through the free radical generation.…”

Section: Introductionmentioning

confidence: 99%

“…Hypoxia and hyperoxia predispose preterm newborns to oxidative stress, through the free radical generation. Antioxidant capacity is lower in the newborn and particularly in the premature infant in comparison to term newborn [ 2 , 3 ]. Therefore, premature infants are especially prone to oxidant injury, in various organs and systems such as lungs, retina and erythrocytes [ 4 – 6 ] with short and long term effects.…”

Section: Introductionmentioning

confidence: 99%

Management of oxygen saturation monitoring in preterm newborns in the NICU: the Italian picture

et al. 2021

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Background Although many studies emphasize the importance of using oxygen saturation (SpO2) targets in the NICUs, there is a wide variability in used saturation ranges among centers. Primary aim was to draw a representative picture on how the management of oxygen monitoring is performed in the Italian NICUs. Second aim was to identify healthcare-professionals related factors associated with oxygen targeting in the preterm population. Methods Cross-sectional study with data collection via an electronic survey form. A questionnaire containing pre-piloted and open questions on monitoring and management of the SpO2 was administered to neonatologists across the network of the Italian Society of Neonatology. The questions focused on: the infrastructure, specific training, healthcare professionals and patients-related factors. The results of the survey were anonymously collected, summarized and analyzed. Results Out of 378 questionnaires, 93 were correctly filled. Thirty-six different SpO2 ranges were observed. Centers using written standard operating procedures on oxygen management and SpO2 monitoring maintained a correct average range of SpO2 90–95%, avoided hyperoxia and reconsidered saturation targets in relation to comorbidities. 39.8% of responders disabled alarms during neonatal care. One center used biomarkers for complete monitoring of neonatal oxygenation status. Conclusions There is considerable variation in SpO2 targets for preterm infants in the Italian NICUs. Standard operating procedures and specific training for health care personnel are the main factors playing a role for the correct maintenance of the recommended oxygen targets in preterms.

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Enzyme Activities in Erythrocytes of Term and Preterm Newborns

Cited by 3 publications

References 32 publications

Management of Oxygen Saturation Monitoring in Preterm Newborns in the NICU: The Italian Picture

Management of Oxygen Saturation Monitoring in Preterm Newborns in the NICU: The Italian Picture

The Free Radical Diseases of Prematurity: From Cellular Mechanisms to Bedside

Management of oxygen saturation monitoring in preterm newborns in the NICU: the Italian picture

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