Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Fatieiev, Yevhen; Croissant, Jonas G.; Julfakyan, Khachatur; Deng, Lin; Anjum, Dalaver H.; Gurinov, Andrey A.; Khashab, Niveen M.

doi:10.1039/c5nr03065j

Cited by 74 publications

(60 citation statements)

References 49 publications

(78 reference statements)

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“…40-60%) of physiologically active organic fragments within the framework. [ 214 ] For incorporating physiologically active organic groups within the framework, bis(propyl)disulfi de and ethylene groups were successfully co-incorporated into the framework of MONs. [ 218 ] It was found that these MONs could be quickly degraded only after incubation in physiological conditions for 48 h (Figure 12 b).…”

Section: Reviewmentioning

confidence: 99%

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Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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Section: Reviewmentioning

confidence: 99%

“…fragments (e.g., disulfi de bonds and oxamide) [ 122,214 ] can be integrated into the framework of MONs. This hybridization strategy can endow hybrid nanosystems with several specifi c biological effects, such as tunable biodegradation and improved biocompatibility.…”

Section: Reviewmentioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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“…[1][2][3][4][5][6][7][8][9] Nonetheless, it remains a challenge to control the kinetic in sol-gel processes, which generally lead to macroscaled nonporous BS functional materials. [10][11][12] Their design involves kinetically-controlled sol-gel processes of bis-or multiorganoalkoxysilanes which yield to hybrid materials with very high organic contents depending on the type of organic groups.…”

Section: Abstract: Bridged Silsesquioxane Dna Delivery Organosilicamentioning

confidence: 99%

Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Fatieiev

Croissant

Alsaiari

et al. 2015

ACS Appl. Mater. Interfaces

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Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene−ammonium bridges are described. The systematic screening of the sol−gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100−200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to −39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

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“…PMO NPs are hybrid nano-objects with very high organic content (~30-70 wt%) and have thus higher properties than organically-doped silica NPs which have lower organic content (~1-30 wt%). [47][48][49][50] Although scalable and relatively cheap to produce, PMO NPs differ from conventional mesoporous silica by their tunable hydrophilicity/hydrophobicity along with many other properties that are associated with the type of organic bridges chosen for the design.…”

Section: Introductionmentioning

confidence: 99%

Engineering Hydrophobic Organosilica Nanoparticle-Doped Nanofibers for Enhanced and Fouling Resistant Membrane Distillation

Hammami

Croissant

Francis

et al. 2017

ACS Appl. Mater. Interfaces

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Engineering and scaling-up new materials for better water desalination are imperative to find alternative fresh water sources to meet future demands. Herein, the fabrication of hydrophobic polyetherimide composite nanofiber membranes doped with novel ethylenepentafluorophenylene-based periodic mesoporous organosilica nanoparticles is reported for enhanced and fouling resistant membrane distillation. Novel organosilica nanoparticles were homogeneously incorporated into electrospun nanofiber membranes depicting a proportional increase of hydrophobicity to the particle contents. Direct contact membrane distillation experiments on the organosilica-doped membrane with only 5 % doping showed an increase of flux of 140 % compared to commercial membranes. The high porosity of organosilica nanoparticles was further utilized to load the eugenol antimicrobial agent which produced a dramatic enhancement of the anti-biofouling properties of the membrane of 70 % after 24 h.

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Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Abstract: We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups.

Cited by 74 publications

References 49 publications

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Engineering Hydrophobic Organosilica Nanoparticle-Doped Nanofibers for Enhanced and Fouling Resistant Membrane Distillation

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