Enzymatically active biomimetic micropropellers for the penetration of mucin gels

Walker, Debora; Käsdorf, Benjamin T.; Jeong, Hyeon‐Ho; Lieleg, Oliver; Fischer, Peer

doi:10.1126/sciadv.1500501

Cited by 273 publications

(262 citation statements)

References 62 publications

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“…Urea was also considered as fuel . In a recent example where urease was used as the engine, Patiño et al reported PS particle‐based micromotors with a rough amine‐functionalized SiO 2 shell urease conjugation .…”

Section: Fuel‐driven Nano/micromotorsmentioning

confidence: 99%

Recent Advances in Nano‐ and Micromotors

Fernández-Medina

Ramos-Docampo

Hovorka

et al. 2020

Adv Funct Materials

163

143

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Nano‐ and micromotors are fascinating objects that can navigate in complex fluidic environments. Their active motion can be triggered by external power sources or they can exhibit self‐propulsion using fuel extracted from their surroundings. The research field is rapidly evolving and has produced nano/micromotors of different geometrical designs, exploiting a variety of mechanisms of locomotion, being capable of achieving remarkable speeds in diverse environments ranging from simple aqueous solutions to complex media including cell cultures or animal tissue. This review aims to provide an overview of the recent developments with focus on predominantly experimental demonstrations of the various motor designs developed in the past 24 months. First, externally driven motors are discussed followed by considering fuel‐driven approaches. Finally, a short future perspective is provided.

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Section: Fuel‐driven Nano/micromotorsmentioning

confidence: 99%

Recent Advances in Nano‐ and Micromotors

Fernández-Medina

Ramos-Docampo

Hovorka

et al. 2020

Adv Funct Materials

163

143

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show abstract

“…We show that swimming occurs in a relatively large zone of Newtonian fluid, and that the assumptions within our approach are consistent with the result. We discuss whether recent artificial swimmers mimicking H. pylori's neutralization strategy [46] may be in the same swimming regime as the bacteria. Effect of local confinement by mucus on swimming.…”

mentioning

confidence: 99%

“…Recently, Walker et al [46] have fabricated artificial magnetic propellers with surface-bound urease to mimic the motility strategy of H. pylori through mucus. In our calculation, the main difference between the artificial propeller and the bacterium is that in the advection-diffusion model the propeller generates a constant flux instead of a constant concentration at its surface.…”

mentioning

confidence: 99%

“…Based on the information provided in Ref. [46] we cannot quantitatively estimate the neutralization zone, but since they emphasize that swimming is only successful for very small acid concentrations, it is possible that the generated flux of ammonia is barely enough to locally neutralize the acid, implying a small neutralization zone. If the neutralization zone is small enough, propeller motility may be controlled by different physics (close-range mucus contact and chemistry) than H. pylori motility.…”

mentioning

confidence: 99%

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Helicobacter pyloriCouples Motility and Diffusion to Actively Create a Heterogeneous Complex Medium in Gastric Mucus

Mirbagheri

2016

Phys. Rev. Lett.

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“…As a result, such designs only concerned with the applications of cargo transport on the swimmer surface, which put significant limitations over the amount of the deliverable cargo, and hence the potential efficacy of the microrobotic operations (29,32,33).…”

Section: Design Fabrication and Mobility Of Microswimmersmentioning

confidence: 99%

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Ceylan

Yasa

Yaşa

et al. 2018

Preprint

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Miniaturization of interventional medical devices can leverage minimally invasive technologiesby enabling operational resolution at cellular length scales with high precision and repeatability.Untethered micron-scale mobile robots can realize this by navigating and performing in hard-toreach, confined and delicate inner body sites. However, such a complex task requires an integrated design and engineering strategy, where powering, control, environmental sensing, medical functionality and biodegradability need to be considered altogether. The present study reports a hydrogel-based, biodegradable microrobotic swimmer, which is responsive to the changes in its microenvironment for theranostic cargo delivery and release tasks. We design a double-helical magnetic microswimmer of 20 µm length, which is 3D-printed with complex geometrical and compositional features. At normal physiological concentrations, matrix metalloproteinase-2 (MMP-2) enzyme can entirely degrade the microswimmer body in 118 h to solubilized non-toxic products. The microswimmer can respond to the pathological concentrations of MMP-2 by swelling and thereby accelerating the release kinetics of the drug payload. Anti-ErbB 2 antibodytagged magnetic nanoparticles released from the degraded microswimmers serve for targeted labeling of SKBR3 breast cancer cells to realize the potential of medical imaging of local tissue sites following the therapeutic intervention. These results represent a leap forward toward clinical medical microrobots that are capable of sensing, responding to the local pathological information, and performing specific therapeutic and diagnostic tasks as orderly executed operations using their smart composite material architectures.

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Enzymatically active biomimetic micropropellers for the penetration of mucin gels

Abstract: Magnetic microparticles decorated with enzymes can penetrate mucin, which is a barrier for most particle-based drug carriers.

Cited by 273 publications

References 62 publications

Recent Advances in Nano‐ and Micromotors

Recent Advances in Nano‐ and Micromotors

Helicobacter pyloriCouples Motility and Diffusion to Actively Create a Heterogeneous Complex Medium in Gastric Mucus

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

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