Enzymatic synthesis of enantiopure alcohols: current state and perspectives

Chen, Bi‐Shuang; Souza, Fayene Zeferino Ribeiro de

doi:10.1039/c8ra09004a

Cited by 54 publications

(33 citation statements)

References 119 publications

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“…Chiral alcohols are important structural and functional motifs in many pharmaceuticals,f ine chemicals and agrochemicals. [15] In the pharma industry,b uilding blocks with chiral hydroxyl moieties are key intermediates of multiple APIs of drug candidates. [16] Therationale,and hence popularity,o fa ccessing chiral alcohols by biocatalysis is obviousstereocontrol in the synthesis,m ild conditions,a bsence of metal-based catalysts and areduced environmental footprint.…”

Section: Alcoholsmentioning

confidence: 99%

Biocatalysis: Enzymatic Synthesis for Industrial Applications

et al. 2020

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in 2007, followed by postdoctoral studies at York University (UK) and Greifswald University (Germany). In 2010, she transitionedto industry applying and developing biocatalytic technologies at Novacta in the UK, prior to joining Chemical Process Development at GSK, with responsibility for the development and implementation of new biocatalytic technologyi nboth pre-and post-commercialization routes. Since Dec. 2016, Radka is leading the Bioreactions group in GDC at the Novartis Institute for Biomedical Research in Basel, Switzerland. Jeffrey Moore obtained his PhD in Chemical Engineeringf rom the California Institute of Technology in 1996 as Frances Arnold's first Directed Evolution graduate student. His foundational work led to an evolved p-nitrobenzyl esterase and the Lonza Centenary Prize (1997). In 1996, he joined the Biocatalysis Group of Merck & Co.in Rahway NJ, spending two decades inventing new enzymes and new enzymatic processes. In 2018, he transitionedtothe Merck Protein EngineeringG roup responsible for evolving enzymes for the discovery,d evelopmenta nd commercials cale manufacture of medicines. He has been awarded aUS Presidential Green Chemistry Award (2010), the BioCat2012 Award (2012) and the Thomas Edison Inventorship Award (2014). Kai Baldenius studied chemistry in Hamburg and Southampton. He received his PhD for research in asymmetric organometallic catalysis, supervised by H. tom Dieck and H. B. Kagan. After his postdoc on natural product synthesis with K. C. Nicolaou at the Scripps Research Institute he joined BASF in 1993. Kai served BASF in various functions (R&D, production, marketing, sales) before he took the lead of BASF'sbiocatalysis research for almost ad efcade. He left BASF to become afree-lancing consultanti n2019 and in 2020 he has founded Baldenius Biotech Consulting. Uwe T. Bornscheuer studied chemistry and received his PhD in 1993 at Hannover University followed by apostdoc at Nagoya University (Japan). In 1998, he completed his Habilitation at Stuttgart University about the use of lipases and esterasesi n organic synthesis. He has been Professor at the Institute of Biochemistry at Greifswald University since 1999. Beside other awards, he received in 2008 the BioCat2008 Award. He was just recognized as "Chemistry Europe Fellow". His current research interest focuses on the discovery and engineering of enzymes from various classes for applications in organic synthesis, lipid modification, degradation of plastics or complex marine polysaccharides.

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Section: Alcoholsmentioning

confidence: 99%

Biocatalysis: Enzymatic Synthesis for Industrial Applications

et al. 2020

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“…Chirale Alkohole sind bedeutende strukturelle und funktionale Motive in vielen Pharmazeutika, Fein-und Agrochemikalien. [15] In der pharmazeutischen Industrie sind Bausteine mit chiralen Hydroxygruppen Schlüsselintermediate fürz ahlreiche APIs von Wirkstoffkandidaten. [16] Die Gründe und folglich Popularität, chirale Alkohole mittels Biokatalyse zugänglich zu machen, liegen auf der Hand -Stereokontrolle in der Synthese,m ilde Reaktionsbedingungen, Abwesenheit von Metall-basierten Katalysatoren und die reduzierte Umweltbelastung.…”

Section: Alkoholeunclassified

Biokatalyse: Enzymatische Synthese für industrielle Anwendungen

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www.angewandte.de 2020 Die Autoren. Verçffentlicht von Wiley-VCH GmbH. Dieser Open Access Beitrag steht unter den Bedingungend er Creative Commons AttributionN on-CommercialN oDerivs License, die eine Nutzung und Verbreitung in allen Medien gestattet, sofern der ursprüngliche Beitrag ordnungsgemäßzitiert und nicht fürkommerzielle Zwecke genutzt wird und keine ¾nderungen und Anpassungen vorgenommen werden.

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“…The application of biocatalysis in this process significantly reduced the number of formed by‐products, waste, organic solvent usage, as well as energy consumption and gas emission thus enabling a green synthesis [4] . The mentioned environmental issues are especially pronounced in the large‐scale industrial production of fine chemicals, and the reaction catalysed by HHDH in this process is a nice example of a perfect atom economy [12c] …”

Section: Halohydrin Dehalogenasesmentioning

confidence: 99%

Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering

et al. 2020

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At the moment, there are approx. 100 published papers investigating halohydrin dehalogenases from different aspects; enzymology, molecular biology and reactions they can catalyse. Unquestionably, these enzymes are of great importance and hold an immense potential due to the wide spectrum of different compounds that can be synthesized by their action. These compounds, such as chiral epoxides, β‐substituted alcohols, oxazolidinones etc., significantly enrich the chemist's toolbox and, moreover, open the possibility for the synthesis of even more complex compounds. Still, there are many unknowns, and it is the purpose of this work to demonstrate the possibilities and bottlenecks, in scientific sense, that could further help in broadening the applicative potential of these fascinating enzymes.

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Enzymatic synthesis of enantiopure alcohols: current state and perspectives

Abstract: Enantiomerically pure alcohols, as key intermediates, play an essential role in the pharmaceutical, agrochemical and chemical industries.

Cited by 54 publications

References 119 publications

Biocatalysis: Enzymatic Synthesis for Industrial Applications

Biocatalysis: Enzymatic Synthesis for Industrial Applications

Biokatalyse: Enzymatische Synthese für industrielle Anwendungen

Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering

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