Enzymatic Sulphation of Bile Salts in Man

Abstract

Enzymatic sulphation of bile salts was identified in cytosol prepared from human adrenal tissue. Unconjugated lithocholate was sulphated at a slightly greater rate than glyco-lithocholate. Chenodeoxycholate and deoxycholate were sulphated at the 7- and 12-OH positions, respectively, but no disulphate formation from these bile salts was found. The physiological implications of these results are discussed.