Enzymatic properties and clinical associations of serum alpha‐galactosidase A in Parkinson's disease
Yasuaki Mizutani,
Kazuki Nawashiro,
Reiko Ohdake
et al.
Abstract:ObjectiveRecent studies have revealed an association between Parkinson's disease (PD) and Fabry disease, a lysosomal storage disorder; however, the underlying mechanisms remain to be elucidated. This study aimed to investigate the enzymatic properties of serum alpha‐galactosidase A (GLA) and compared them with the clinical parameters of PD.MethodsThe study participants consisted of 66 sporadic PD patients and 52 controls. We measured serum GLA activity and calculated the apparent Michaelis constant (Km) and ma… Show more
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