Enzymatic necrolysis of acute deep burns—Report of preliminary results with 23 patients

Koller, Ján; Bukovčan, Peter; Orság, M; Kvalteni, R.; Gräffinger, I

doi:10.1016/j.burns.2009.06.142

Cited by 8 publications

(11 citation statements)

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“…All studies in the systematic review that reported (1) control cohorts (non-CCO) and (2) variance were included in the meta-analysis. Combined effect size estimates and odds ratios (ORs) were computed with 95% confidence intervals (CI) for the outcomes that fit criteria for meta-analysis.…”

Section: Incorporated Statistical Analysis To Support Conclusionmentioning

confidence: 99%

“…Globally the two most popular products are derived from bacterial collagenase and bromelain, an enzyme found in pineapple stems. Bromelain-based products have attained widespread use [1][2][3][4][5][6][7][8][9][10] and have demonstrated superiority over traditional wound care with silver-impregnated products 1 . A recent review 11 has recently examined the evidence behind bromelain-based products.…”

Section: Introductionmentioning

confidence: 99%

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The role of collagenase ointment in acute burns: a systematic review and meta-analysis

et al. 2019

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Aims: Clostridial collagenase ointment (CCO) is the only FDA-approved product for enzymatic debridement in the United States. Its efficacy in the burn patient has not been extensively examined. A systematic review and meta-analysis was performed to summarize the state of the literature in regard to the efficacy and uses of CCO in the burn patient. Methods: A systematic review of articles available on PubMed, Scopus, and OvidSP Medline was performed. Keywords utilized in the search process included: burns; thermal injury; collagenase; enzymatic debridement; wound care. Excluded articles included reviews, case reports, independent abstracts, consensus and opinion papers. A meta-analysis was performed for articles fitting inclusion criteria. Results: Six relevant articles were identified for systematic review. Few studies, with limited sample sizes, argue that collagenase ointment may be an effective debriding agent. CCO may also accelerate wound healing and avoid the pain associated with mechanical debridement. CCO lacks anti-microbial activity but the risk of burn wound infection does not appear to be significantly different than when using silver-impregnated products. CCO is more expensive than traditional wound care products but may halt burn depth conversion and prevent the need for surgery. Conclusions: CCO may be a safe and effective debridement agent for burn wounds with respect to decreasing wound healing time and minimizing pain without increasing the risk of infection. It should be used on a case-by-case basis due to its financial cost. The financial cost of CCO may be offset by its ability to manage burns non-operatively.

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Section: Incorporated Statistical Analysis To Support Conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of collagenase ointment in acute burns: a systematic review and meta-analysis

et al. 2019

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“…Various studies refer to bromelain debriding action, removing the necrotic layer of epidermis, which could serve as an excellent culture medium for opportunistic pathogens (Cordts et al, 2016;Ekambaram, Rachita, Manikantan Syamala, & Purna Sai, 2017;Houck, Chang, & Klein, 1983;Hu et al, 2011;Maurer, 2001;Rosenberg et al, 2004;Rosenberg et al, 2014;Sheridan, Tompkins, & Burke, 1994;Singer et al, 2010;Wu et al, 2012). Local application of bromelain has been shown to be rapid, effective, non-invasive, safe, easily performed at the bedside with minimal or no blood loss and negligibly interfere with natural wound healing processes (Koller, Bukovcan, Orsag, Kvalteni, & Graffinger, 2008;Muhammad & Ahmad, 2017). Bromelain also accelerates the healing of burn wounds in humans (Krieger et al, 2012), showing antioxidant and antimicrobial activities (Ataide, de Carvalho, et al, 2017;Ali, Milala, & Gulani, 2015;Dutta & Bhattacharyya, 2013;Praveen et al, 2014;Manosroi, Chankhampan, Pattamapun, Manosroi, & Manosroi, 2014).…”

Section: Bromelainmentioning

confidence: 99%

“…Commercial enzymatic debriding agents are available, and some previous studies reported their efficacy mainly in the treatment of burn wounds (Cordts et al, 2016;Rosenberg et al, 2014;Schulz et al, 2017) and to clear bruises and hematomas on boxers (Blonstein, Bromelain (Dutta & Bhattacharyya, 2013;Ali et al, 2015;Praveen et al, 2014;Manosroi et al, 2014;Ataide, de Carvalho, et al, 2017;Ekambaram et al, 2017) (Dutta & Bhattacharyya, 2013;Hu et al, 2011;Singer et al, 2010;Wu et al, 2012) (Blonstein, 1960;Cordts et al, 2016;Koller et al, 2008;Krieger et al, 2012;Rosenberg et al, 2004;Rosenberg et al, 2014;Schulz et al, 2017) Propolis ( Centella asiatica (Hong et al, 2005;Shukla, Rasik, Jain, et al, 1999;Gohil et al, 2010;Incandela et al, 2001;Zhang et al, 2016) (Shukla, Rasik, Jain, et al, 1999;Sawatdee et al, 2016;Gohil et al, 2010;Gul Satar et al, 2013;Sunilkumar et al, 1998;Rosen et al, 1967;Incandela et al, 2001;Poizot & Dumez, 1978;Suguna et al, 1996;Zhang et al, 2016) …”

Section: Bromelainmentioning

confidence: 99%

Natural actives for wound healing: A review

Ataide

Cefali

Croisfelt

et al. 2018

Phytotherapy Research

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Nature has been a source of medicinal treatments for thousands of years, with the use of plants as prototypes for drug development and for the extraction of active compounds. Skin injuries occur regularly in everyday life, and the human skin has the ability to promote repair spontaneously under healthy conditions. However, some intrinsic and external factors may interfere with skins' natural ability, leading to nonhealing lesions and chronic wounds, which directly affect health and quality of life. Thus, attention should be given to this health problem, using an appropriated management when necessary. In this scenario, phytotherapy may be an option for cutaneous wound treatment, although further high-quality studies are needed to firmly establish the clinical efficacy of plants. This article reviews traditionally used natural actives for wound healing, highlighting their characteristics and mode of action.

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“…[8] It is mainly reported in treatment of Rheumatoid arthritis [9][10][11][12] , Cancer [13][14][15][16] and Gastro intestinal disturbances. [17,18] And found to have actions like immunogenicity, platelet aggregation, wound healing [19][20][21][22][23][24][25] , antioxidant, antimicrobial and antidiarrheal. Its anti-inflammatory activity is helpful in the treatment of angioedema.…”

Section: Introductionmentioning

confidence: 99%

Potency Evaluation of Combined Therapy of Losartan and Ananas Comosus During Isoprenaline Mediated Cardiac Dysfucntion in Rats

Attuluri¹

2017

WJPPS

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The present study was carried out to explore the cardioprotective potency of pineapple (ananas comusus) with losartan in isoprenaline(ISO) induced acute and chronic myocardial damage in rats. The purpose of the study research was to uncover the potency of anti inflammatory activity of pineapple on necrotic myocardium, in combination with angiotensin blocker losartan(LTN). In acute model, Sprague Dawley rats were pre-treated with losartan(LTN) (30 mg/kg, ten days, po), low,intermediate and high doses of pineapple (100, 250 and 500 mg/kg, 30 days, po) and subsequently subjected to ISO administration (150 mg/kg, s.c) for two consecutive days. The influence of prophylactic treatment was analysed by quantification of biomarkers, antioxidants and histopathological observations. LDH and CK-MB activities were studied in serum and heart tissue homogenate (HTH) where as SOD, catalase and TBARS were estimated in HTH. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

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Enzymatic necrolysis of acute deep burns—Report of preliminary results with 23 patients

Cited by 8 publications

References 0 publications

The role of collagenase ointment in acute burns: a systematic review and meta-analysis

The role of collagenase ointment in acute burns: a systematic review and meta-analysis

Natural actives for wound healing: A review

Potency Evaluation of Combined Therapy of Losartan and Ananas Comosus During Isoprenaline Mediated Cardiac Dysfucntion in Rats

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