Enzymatic Modulation of Bronchoconstriction, Gland Secretion, Plasma Extravasation and Cough.

Sekizawa, Kiyohisa

doi:10.1620/tjem.172.295

Tohoku J. Exp. Med.

1994

DOI: 10.1620/tjem.172.295

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Enzymatic Modulation of Bronchoconstriction, Gland Secretion, Plasma Extravasation and Cough.

Kiyohisa Sekizawa

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Cited by 2 publications

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References 132 publications

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“…Leukotriene (LT) and histamine are important factors associated with the pathogenesis of bronchial asthma (Barnes et al 1988;Sekizawa 1994). Influenza virus infection increases basophil LTC 4 release (Huftel et al 1992).…”

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confidence: 99%

Inflammatory and Bronchospastic Factors in Asthma Exacerbations Caused by Upper Respiratory Tract Infections

Yasuda

Suzuki

Zayasu

et al. 2005

Tohoku J. Exp. Med.

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It is still uncertain how viral respiratory infections cause acute exacerbations of bronchial asthma, although several mechanisms have been proposed. We studied the relationship between the airway narrowing and the inflammatory and bronchospastic factors in peripheral venous blood and urine, in 30 patients with asthma at the exacerbations caused by upper respiratory tract infections (URTIs). Acute exacerbations caused decreases in peak expiratory flow rate (PEFR) in all 30 patients with asthma. Asthma exacerbations caused the rises in serum levels of interleukin-6, soluble intercellular adhesion molecule-1 and eosinophil cationic protein, concentrations of urinary leukotriene E 4 and plasma histamine, compared with those in patients with asthma at a stable condition and those in 30 control subjects (p < 0.05). The values of PEFR at the exacerbations correlated with the levels of these factors. Treatment with oral glucocorticoids reversed the decreases in PEFR and the increases in these factors. At the onset of URTIs, rhinovirus and influenza type A virus were identified in 13 and 7 patients, respectively. Each of parainfluenza virus, adenovirus, and enterovirus was identified in one patient. These findings suggest that respiratory viral infections may cause acute asthma exacerbations via the production of mediators that induce inflammation and bronchospasm. bronchial asthma; virus infection; interleukin-6; ICAM-1; leukotriene; histamine

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confidence: 99%

Inflammatory and Bronchospastic Factors in Asthma Exacerbations Caused by Upper Respiratory Tract Infections

Yasuda

Suzuki

Zayasu

et al. 2005

Tohoku J. Exp. Med.

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Care for Older People

2003

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Aging is often seen as disadvantageous in humanhistory. However, longevity reduces medical costs of the whole life compared with that of short life. Therefore, in order to reduce medical cost, we have to take care of the elderly in order to promote health and longevity. Health problems in the elderly should be solved by both medical and elderly care facilities.However, few studies have analyzed the care problems of the elderly. In this review, we describe the recent methods of care for the elderly. (Internal Medicine 42: 932-940, 2003)

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Enzymatic Modulation of Bronchoconstriction, Gland Secretion, Plasma Extravasation and Cough.

Cited by 2 publications

References 132 publications

Inflammatory and Bronchospastic Factors in Asthma Exacerbations Caused by Upper Respiratory Tract Infections

Inflammatory and Bronchospastic Factors in Asthma Exacerbations Caused by Upper Respiratory Tract Infections

Care for Older People

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