“…These bases occur in nature in the phospho-and glycosphingolipids, which can be regarded as derivatives of ceramide, the N-acylated sphingosine base (reviewed in Hanahan and Brockerhofif, 1965). Enzymes which hydrolyze the sphingolipids of animal origin have been isolated (Gatt, 1963(Gatt, ,b, 1967Barenholz and Gatt, 1966;Rapport, 1965, 1966a,b;Gatt, 1966, 1967a,b, Leibovitz and Gatt, 1968;Heller and Shapiro, 1966;Brady et al, 1965aBrady et al, ,b, 1967Hajra et al, 1966;Sandhoff and Jatzkewitz, 1967;Schneider and Kennedy, 1967). These enzymes can account for the complete, stepwise hydrolysis of the sphingolipids to a long-chain base, fatty acid, and the individual carbohydrate residues, or phosphorylchloline (summarized in ).…”