Enzymatic Halogenation in Stereoselective Synthesis

Abstract

Halogenation of biologically active compounds is an attractive method for moderating their properties. Although there are numerous synthetic methodologies for halogen incorporation, biological alternatives are attractive because of the characteristics of enzyme‐catalyzed reactions, such as mild conditions of temperature and pH, and the avoidance of noxious reagents. In recent years, our understanding of the enzymology of halogenation has increased dramatically, and several new classes of enzymes catalyzing electrophilic, nucleophilic, and free radical halogenations have been identified. Furthermore, advances in molecular biology and genome sequencing have widened the possibilities of employing microorganisms to elaborate novel halogenated compounds with valuable medicinal properties.

Estratégias para síntese em fluxo contínuo de novos heterociclos nitrogenados e espiroimidas

“…Há um grande interesse em descobrir e explorar essas enzimas 179 , vislumbrando sua aplicação como catalisadores em síntese orgânica. 181 Dentre os grupos de enzimas que catalisam a halogenação dos compostos naturais destacase a haloperoxidase, 182 um grupo capaz de introduzir átomo de halogênio em moléculas orgânicas nucleofílicas. A classificação das haloperoxidases ocorre segundo o co-fator metálico presente no sítio ativo da enzima: haloperoxidase dependente de vanádio, dependente de heme ou livre de metal.…”