Enzymatic Glucose Fiber Sensor for Glucose Concentration Measurement with a Heterodyne Interferometry

Hsu, C. S.; Chung, Wan-Yu; Chang, Chin Hao; Wu, Chyan-Chyi; Lee, Cheng‐Ling

doi:10.3390/s23062990

Cited by 3 publications

(4 citation statements)

References 27 publications

(72 reference statements)

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“…Therefore, developing new methods for long-term glucose monitoring is necessary, since real-time glucose monitoring has more value in clinical applications and is in line with current market trends [7]. Several alternative methods for glucose sensors have been developed, such as fluorescence [8], electrochemical [9], high-performance liquid chromatography (HPLC) [10], enzymatic methods [11], colorimetric assays [12], and surface-enhanced Raman spectroscopy (SERS) [13,14]. SERS has a significant advantage over the other methods because it is a non-destructive technique with high sensitivity and the capability of reading molecular fingerprints; this technique uses noble metals such as Au, Ag, and Cu in the form of nanostructures for the enhancement of the Raman signal by several orders of magnitude [15,16].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles in Porous Silicon Nanotubes for Glucose Detection

Gonzalez-Rodriguez,

Hathaway,

Coffer

et al. 2024

Chemosensors

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Silicon nanotubes (Si NTs) have a unique structure among the silicon nanostructure family, which is useful for diverse applications ranging from therapeutics to lithium storage/recycling. Their well-defined structure and high surface area make them ideal for sensing applications. In this work, we demonstrate the formation of Au nanoparticles (NPs) functionalized with 4-Mercaptophenylboronic acid (MPBA) on porous Si NTs (pSi NTs) fabricated using ZnO nanowires as a template. The system was characterized, and the proposed structure was confirmed using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). Varying glucose concentrations in phosphate-buffered saline (PBS) (0.5–80 mM) were introduced to the Si NT nanocomposite system. The glucose is detectable at low concentrations utilizing surface-enhanced Raman spectroscopy (SERS), which shows a concentration-dependent peak shift in the benzene ring breathing mode (~1071 cm−1) of MPBA. Complementing these measurements are simulations of the Raman hot spots associated with plasmonic enhancement of the Au NPs using COMSOL. This biocompatible system is envisioned to have applications in nanomedicine and microfluidic devices for real-time, non-invasive glucose sensing.

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Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles in Porous Silicon Nanotubes for Glucose Detection

Gonzalez-Rodriguez,

Hathaway,

Coffer

et al. 2024

Chemosensors

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“…For example, Liao et al developed an electrochemical sensor for detecting glucose by depositing Pt nanoparticles on a SiC@C nanowire and immobilizing GluOx [15]. Hsu et al prepared a enzymatic glucose fiber sensor that could detect glucose concentration in the range of 10-550 mg/L on the basis of amount of phase variation [16]. Abrar and co-workers developed an amperometric lactate biosensor by modifying silver electrode with lactate oxidase, Sensors 2024, 24, 3447 2 of 13 which shows the linear response to lactate concentration of 1-25 mM [17].…”

Section: Introductionmentioning

confidence: 99%

“…[ 12 , 13 , 14 ]. Electrochemical assays have been widely used for detecting glucose and lactic acid due to their convenient operation and fast response [ 15 , 16 , 17 , 18 ]. For example, Liao et al developed an electrochemical sensor for detecting glucose by depositing Pt nanoparticles on a SiC@C nanowire and immobilizing GluOx [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Fluorescent Detection of Glucose and Lactic Acid Based on Fluorescent Iron Nanoclusters

Ge,

Mao,

Wang

et al. 2024

Sensors

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In this paper, a novel fluorescent detection method for glucose and lactic acid was developed based on fluorescent iron nanoclusters (Fe NCs). The Fe NCs prepared using hemin as the main raw material exhibited excellent water solubility, bright red fluorescence, and super sensitive response to hydrogen peroxide (H2O2). This paper demonstrates that Fe NCs exhibit excellent peroxide-like activity, catalyzing H2O2 to produce hydroxyl radicals (•OH) that can quench the red fluorescence of Fe NCs. In this paper, a new type of glucose sensor was established by combining Fe NCs with glucose oxidase (GluOx). With the increase in glucose content, the fluorescence of Fe NCs decreases correspondingly, and the glucose content can be detected in the scope of 0–200 μmol·L−1 (μM). Similarly, the lactic acid sensor can also be established by combining Fe NCs with lactate oxidase (LacOx). With the increase in lactic acid concentration, the fluorescence of Fe NCs decreases correspondingly, and the lactic acid content can be detected in the range of 0–100 μM. Furthermore, Fe NCs were used in the preparation of gel test strip, which can be used to detect H2O2, glucose and lactic acid successfully by the changes of fluorescent intensity.

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“…After introducing GOx, the interference of other substances on the measurement results can be reduced. In our previous study [11], we deposited the GOx on the surface of a single-mode fiber, and heterodyne interferometry was used to measure the phase change of the glucose solution under test. The measurement time can be significantly shortened to 1.3 s, the best measurement resolution can reach 0.141 mg/dL, and the fiber can be reused up to 10 times.…”

Section: Introductionmentioning

confidence: 99%

Glucose Concentration Measurement by All-Grating-Based System

Hsieh

Huang

2023

Sensors

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An accurate, easy setup, low-cost, and time-saving method for measuring glucose concentration was proposed. An all-grating-based glucose concentration measurement system contained moving-grating-based heterodyne interferometry and a grating-based self-align sensor. By combining the first-order diffraction lights from two separated moving gratings by a polarization beam splitter and creating S- and P-polarized light interference by an analyzer, the interference signal could be a heterodyne light source with a heterodyne frequency depending on the relative velocities of the two moving gratings. Next, a grating-based self-align sensor was used to make the optical configuration setup easy and accurate. Moreover, the sensor was deposited on GOx film to improve the measurement sensitivity and specificity for glucose. Finally, the phase change induced by the reaction of the sensor and glucose solutions was detected. The validity of this method was proved, and the measurement resolution can reach 2 mg/dL.

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Enzymatic Glucose Fiber Sensor for Glucose Concentration Measurement with a Heterodyne Interferometry

Cited by 3 publications

References 27 publications

Gold Nanoparticles in Porous Silicon Nanotubes for Glucose Detection

Gold Nanoparticles in Porous Silicon Nanotubes for Glucose Detection

The Fluorescent Detection of Glucose and Lactic Acid Based on Fluorescent Iron Nanoclusters

Glucose Concentration Measurement by All-Grating-Based System

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