Enzymatic glucose biosensor based on manganese dioxide nanoparticles decorated on graphene nanoribbons

Vukojević, Vesna; Đurđić, Slađana; Ognjanović, Miloš; Fábian, Martin; Samphao, Anchalee; Kalcher, Kurt; Stanković, Dalibor M.

doi:10.1016/j.jelechem.2018.07.013

Cited by 86 publications

(51 citation statements)

References 41 publications

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“…The diameter of semi-circle, R ct (Z'), can be observed to decrease at higher tyrosine levels. As already reported earlier [22], the latter releases more electrons at higher concentrations which enables rapid charge transport (low R ct ) at C/α-MnO 2 /tyrosinase surface from electrolyte. This indicates higher current response (I pa ) at elevated tyrosine levels (Figure 4 (A)).…”

Section: Validation Of the Developed Smart Band-aidsupporting

confidence: 71%

“…The exploitation of nanomaterials in electrochemical bio-sensors have been intensively explored owing to enhanced surface to volume ratio, thereby opening prospects of diverse functionalization, and quantum confinement effects [15][16][17][18][19][20]. Among the vast array of nanomaterials, MnO 2 nanostructures have garnered considerable interest due to its non-toxic nature which makes them potential biocompatible sensing platforms [21][22][23]. Bai et al reported the voltammetric detection of choline using choline oxidase (ChOx)/MnO 2 /chitosan modified glassy carbon electrode [24].…”

Section: Introductionmentioning

confidence: 99%

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Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

et al. 2020

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L‐tyrosine is an amino acid, the concentration of which is found to be highly elevated in patients suffering from diabetic foot ulcer (DFU). The latter proves to be fatal when it turns out chronic and may lead to amputation. The conventional clinical diagnostic methods are costly and time consuming, in which case, the condition of patient(s) may deteriorate long before proper treatment commences. Herein, we report the development of smart band‐aid for real time monitoring of L‐tyrosine by employing enzymatic bio‐sensor using α‐MnO2/tyrosinase. The smart band‐aid was further integrated with portable electronics capable of wireless data transmission to a personal digital assistant, and its tyrosine sensing performance was evaluated. Anodic current was found to vary linearly with the concentrations of L‐tyrosine in the range of 5 nM–500 μM. The developed sensor displayed a limit of detection and sensitivity of 0.71 nM and 0.67 μA/nM/mm2 respectively, with a stability of 25 days. The developed sensor was validated using a commercial impedance analyzer. The impedance response was found to be consistent with the cyclic voltammogram obtained and demonstrated to be a linear function of tyrosine concentration. The developed sensing platform combines early diagnosis with connected health technologies, thus, fitting well into modern healthcare needs.

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Section: Validation Of the Developed Smart Band-aidsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

et al. 2020

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“…Graphene nanoribbons (GNRs) were prepared as described in literature with some little modifications [24,25]. Briefly, a suspension was formed by dissolving 100 mg of MWCNT in 3.4 mL of 98% H 2 SO 4 and then homogenized via ultrasonication for 1 h. ereafter, the suspension solution was placed in an ice bath accompanied with vigorous stirring and 75 mg of NaNO 3 was then added.…”

Section: Preparation Of Graphene Nanoribbonsmentioning

confidence: 99%

TiO₂ Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine

Apath

Moyo

Shumba

2020

Journal of Chemistry

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In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The electrochemical behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (−37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020–0.14 µM. The detection limit was calculated as 0.043 µM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully.

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“…Different nanomaterials and composites were used as active surface modifiers. For instance, graphene nanoribbons (GNs), known as one‐dimensional strips of graphene find nowadays wide applications in the field of electrochemical sensors and biosensors and as high capacity electrode materials . Similarly, cerium dioxide showed excellent characteristics in various fields of electrochemistry, as an electrode material for supercapacitors and for sensing applications .…”

Section: Introductionmentioning

confidence: 99%

Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications

et al. 2019

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A disposable acetaminophen biosensor based on inkjet‐printed CNT electrodes (IJPCNT) modified with amidase/cerium dioxide@graphene nanoribbons composite was developed (ACeO2@GNR/IJPCNT). The enzyme amidase A was used for the first time as a recognition element. Inkjet‐printed CNT electrodes served as a basis for the construction of a biosensor that enables droplet detection using 5 μL sample volume. The biosensor showed high selectivity, sensitivity, a low detection limit of 0.18 μM and a wide working linear range from 1 to 100 μM. The proposed approach allows fast and reliable detection of acetaminophen in biological fluids with negligible matrix effect and remarkable reproducibility.

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Enzymatic glucose biosensor based on manganese dioxide nanoparticles decorated on graphene nanoribbons

Cited by 86 publications

References 41 publications

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

TiO₂ Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine

Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications

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Enzymatic glucose biosensor based on manganese dioxide nanoparticles decorated on graphene nanoribbons

Cited by 86 publications

References 41 publications

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine

Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet‐printed CNT Electrodes‐droplet Based Paracetamol Detection in Biological Fluids for “Point‐of‐care” Applications

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TiO₂ Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine